TDIF1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TDIF1_MOUSE
• UniProt AC: Q99LB0
• Protein Name: Deoxynucleotidyltransferase terminal-interacting protein 1
• Gene Name: Dnttip1
• Organism: Mus musculus (Mouse).
• Sequence Length: 328
• Subcellular Localization: Nucleus .
• Protein Description: Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA..
• Protein Sequence: MGATGDTEQPRGPGGAERGGLELGDAGAAGQPVLTNPWNIMIKHRQVQRRGRRSQMTTSFTDPAISMDLLRAVLQPSINEEIQGVFNKYMKFFQKAALNVRDNVGEEVDAEQLIQEACRSCLEQAKLLFSDGEKVIPRLAHELPGIKRGRQAEEESHRGSPIPKKRKGRPPGHVLSNDRAAAGMVWKQKSCEPIRREGPKWDPARLNESTTFVLGSRANKALGMGGTRGRIYIKHPHLFKYAADPQDKHWLAEQHHMRATGGKMAYLLIEEDIRDLAASDDYRGCLDLKLEELKSFVLPSWMVEKMRKYMETLRTENEHRAAEAPPQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	VQRRGRRSQMTTSFT HHHCCCCCCCCCCCC	23.96	28066266
57	Phosphorylation	RGRRSQMTTSFTDPA CCCCCCCCCCCCCHH	16.20	28066266
58	Phosphorylation	GRRSQMTTSFTDPAI CCCCCCCCCCCCHHH	19.25	28066266
59	Phosphorylation	RRSQMTTSFTDPAIS CCCCCCCCCCCHHHC	19.58	28066266
134	Ubiquitination	LLFSDGEKVIPRLAH HHCCCCCCHHHHHHH	51.50	-
156	Phosphorylation	GRQAEEESHRGSPIP CHHHHHHHHCCCCCC	23.05	25619855
160	Phosphorylation	EEESHRGSPIPKKRK HHHHHCCCCCCCCCC	21.44	26824392
210	Phosphorylation	PARLNESTTFVLGSR HHHCCCCCEEEECCH	20.34	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TDIF1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TDIF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TDIF1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of TDIF1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.