GRHL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRHL2_MOUSE
• UniProt AC: Q8K5C0
• Protein Name: Grainyhead-like protein 2 homolog
• Gene Name: Grhl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 625
• Subcellular Localization: Nucleus . Membrane . detected at cell-cell contact areas.
• Protein Description: Transcription factor playing an important role in primary neurulation and in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes. [PubMed: 22696678 During embryogenesis, plays unique and cooperative roles with GRHL3 in establishing distinct zones of primary neurulation. Essential for closure 3 (rostral end of the forebrain), functions cooperatively with GRHL3 in closure 2 (forebrain/midbrain boundary) and posterior neuropore closure]
• Protein Sequence: MSQESDNNKRLVALVPMPSDPPFNTRRAYTSEDEAWKSYLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRDKRLLSVSKASDSQEDQDKRNCLGTSEAQINLSGGENRVQVLKTVPVNLCLSQDHMENSKREQYSVSITESSAVIPVSGITVVKAEDFTPVFMAPPVHYPRADSEEQRVVIFEQTQYDLPSIASHSSYLKDDQRSTPDSTYSESFKDGASEKFRSTSVGADEYTYDQTGSGTFQYTLEATKSLRQKQGEGPMTYLNKGQFYAITLSETGDNKCFRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDVNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPIHRAYCQIKVFCDKGAERKIRDEERKQNRKKGKGQASQAQCNNSSDGKMAAIPLQKKSDITYFKTMPDLHSQPVLFIPDVHFANLQRTGQVYYNTDDEREGSSVLVKRMFRPMEEEFGPTPSKQIKEENVKRVLLYVRKENDDVFDALMLKSPTVKGLMEALSEKYGLPVEKITKLYKKSKKGILVNMDDNIIEHYSNEDTFILNMESMVEGFKITLMEI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	PRDKRLLSVSKASDS CCCHHCEEEECCCCC	29.01	22006019
139	Phosphorylation	ENSKREQYSVSITES HCCCCEEEEEEEECC	13.29	26060331
140	Phosphorylation	NSKREQYSVSITESS CCCCEEEEEEEECCC	14.75	26060331
142	Phosphorylation	KREQYSVSITESSAV CCEEEEEEEECCCEE	20.18	26060331
144	Phosphorylation	EQYSVSITESSAVIP EEEEEEEECCCEEEE	23.47	26060331
146	Phosphorylation	YSVSITESSAVIPVS EEEEEECCCEEEECC	18.23	26060331
147	Phosphorylation	SVSITESSAVIPVSG EEEEECCCEEEECCC	21.96	26060331
153	Phosphorylation	SSAVIPVSGITVVKA CCEEEECCCEEEEEC	21.08	26060331
156	Phosphorylation	VIPVSGITVVKAEDF EEECCCEEEEECCCC	23.83	26060331
210	Phosphorylation	YLKDDQRSTPDSTYS HCCCCCCCCCCCCCC	38.36	23375375
211	Phosphorylation	LKDDQRSTPDSTYSE CCCCCCCCCCCCCCH	33.05	23375375
214	Phosphorylation	DQRSTPDSTYSESFK CCCCCCCCCCCHHHC	30.37	23375375
215	Phosphorylation	QRSTPDSTYSESFKD CCCCCCCCCCHHHCC	38.15	-
217	Phosphorylation	STPDSTYSESFKDGA CCCCCCCCHHHCCCC	27.18	23375375
308	Acetylation	MVVFSEDKNRDEQLK EEEEECCCCHHHHHH	50.24	6569275
466	Phosphorylation	LQKKSDITYFKTMPD CEECCCCEEEECCCC	28.09	-
467	Phosphorylation	QKKSDITYFKTMPDL EECCCCEEEECCCCC	11.92	-
500	Phosphorylation	TGQVYYNTDDEREGS CEEEEECCCCCCCCC	28.80	28973931
541	Phosphorylation	NVKRVLLYVRKENDD CCEEEEEEEECCCCC	8.27	-
557	Phosphorylation	FDALMLKSPTVKGLM HHHHHHCCHHHHHHH	23.11	26745281
559	Phosphorylation	ALMLKSPTVKGLMEA HHHHCCHHHHHHHHH	41.77	26745281
568	Phosphorylation	KGLMEALSEKYGLPV HHHHHHHHHHHCCCH	38.81	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRHL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRHL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRHL2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of GRHL2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.