PCGF6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCGF6_MOUSE
• UniProt AC: Q99NA9
• Protein Name: Polycomb group RING finger protein 6
• Gene Name: Pcgf6
• Organism: Mus musculus (Mouse).
• Sequence Length: 353
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity..
• Protein Sequence: MDEAETDATENKRASEAKRASAMPPPPPPPPPISPPALIPAPAAGEEGPASLGQAGAAGCSRSRPPALEPERSLGRLRGRFEDYDEELEEEEEMEEEEEEEEEMSHFSLRLESGRADSEDEEERLINLVELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAAPQPVPSSKGKTKKVLESVFRIPPELDMSLLLEFIGANEDTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLERYQTLREIRRAIGDTAMQDGLLVLHYGLVVSPLKIT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	ASEAKRASAMPPPPP HHHHHHHHCCCCCCC	29.18	26745281
34	Phosphorylation	PPPPPPISPPALIPA CCCCCCCCCCCEEEC	30.52	22006019
51	Phosphorylation	AGEEGPASLGQAGAA CCCCCCCCHHHCCCC	35.84	26745281
113	Phosphorylation	HFSLRLESGRADSED HHHHHHHCCCCCCCC	37.86	26239621
118	Phosphorylation	LESGRADSEDEEERL HHCCCCCCCCHHHHH	46.06	27087446
200	Ubiquitination	QLQDIVYKLVINLEE HHHHHHHHHHHCHHH	25.94	-
348	Phosphorylation	LHYGLVVSPLKIT-- EEEEEEEECCCCC--	19.62	26745281

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCGF6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCGF6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCGF6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PCGF6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.