PSD12_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PSD12_MOUSE
• UniProt AC: Q9D8W5
• Protein Name: 26S proteasome non-ATPase regulatory subunit 12
• Gene Name: Psmd12
• Organism: Mus musculus (Mouse).
• Sequence Length: 456
• Protein Description: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair..
• Protein Sequence: MADGGSERADGRIVKMEVDYSATVDQRLPECEKLAKEGRLQEVIETLLSLEKQTRTASDMVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQLKQAVAKMVQQCCTYVEEITDLPVKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETYGSMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEENTENLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESDKWQQALKSVVLYVILAPFDNEQSDLVHRISSDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGVELRKGSSETPATDVFSSTEEGEKRWKDLKSRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGVINFQRPKDPNNLLNDWSQKLNSLMSLVNKTTHLIAKEEMIHNLQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MADGGSERA ------CCCCCCCCC	24.93	16857966
6	Phosphorylation	--MADGGSERADGRI --CCCCCCCCCCCCE	29.46	25619855
20	Phosphorylation	IVKMEVDYSATVDQR EEEEEEEECCCCCCC	12.84	29895711
23	Phosphorylation	MEVDYSATVDQRLPE EEEEECCCCCCCCHH	20.76	29895711
31	Glutathionylation	VDQRLPECEKLAKEG CCCCCHHHHHHHHHC	5.44	24333276
33	Malonylation	QRLPECEKLAKEGRL CCCHHHHHHHHHCCH	66.46	26320211
92	Acetylation	ENIMLLSKRRSQLKQ HHHHHHHHHHHHHHH	52.37	30976145
98	Malonylation	SKRRSQLKQAVAKMV HHHHHHHHHHHHHHH	28.68	26320211
153	Ubiquitination	TKTLATIKEQNGDVK HHHHHHHHHHCCCHH	49.22	-
173	Phosphorylation	LQELQVETYGSMEKK HHHHHCCCCCCCCHH	34.03	26643407
176	Phosphorylation	LQVETYGSMEKKERV HHCCCCCCCCHHHHH	17.23	26643407
212	Acetylation	ISKKINTKFFQEENT HHHHHCCHHCCCCCC	39.43	66693985
212	Ubiquitination	ISKKINTKFFQEENT HHHHHCCHHCCCCCC	39.43	27667366
212	Malonylation	ISKKINTKFFQEENT HHHHHCCHHCCCCCC	39.43	26320211
255	S-palmitoylation	RAIYDTPCIQAESDK HHHHCCCCCCCCCHH	3.80	28526873
310	Phosphorylation	KDLLKLFTTMELMRW HHHHHHHHHHHHHHH	35.35	27357545
311	Phosphorylation	DLLKLFTTMELMRWS HHHHHHHHHHHHHHH	11.00	24759943
330	Ubiquitination	DYGVELRKGSSETPA HHCCEECCCCCCCCC	75.63	-
332	Phosphorylation	GVELRKGSSETPATD CCEECCCCCCCCCCC	28.21	25521595
335	Phosphorylation	LRKGSSETPATDVFS ECCCCCCCCCCCCCC	21.85	25338131
342	Phosphorylation	TPATDVFSSTEEGEK CCCCCCCCCCHHHHH	35.88	26525534
343	Phosphorylation	PATDVFSSTEEGEKR CCCCCCCCCHHHHHH	28.51	28464351
368	Acetylation	HNIRIMAKYYTRITM HHHHHHHHHHHHHHH	22.78	-
400	Ubiquitination	LSNLVVNKTIFAKVD HHHHCCCCCHHHHHH	31.24	-
405	Acetylation	VNKTIFAKVDRLAGV CCCCHHHHHHHHHCC	33.64	22826441
448	Acetylation	KTTHLIAKEEMIHNL HHHHHHHHHHHHHHC	47.41	23236377
448	Ubiquitination	KTTHLIAKEEMIHNL HHHHHHHHHHHHHHC	47.41	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PSD12_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PSD12_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PSD12_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of PSD12_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.