RIF1_MOUSE - dbPTM
RIF1_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIF1_MOUSE
UniProt AC Q6PR54
Protein Name Telomere-associated protein RIF1 {ECO:0000305}
Gene Name Rif1 {ECO:0000312|MGI:MGI:1098622}
Organism Mus musculus (Mouse).
Sequence Length 2419
Subcellular Localization Nucleus . Chromosome . Chromosome, telomere . Cytoplasm, cytoskeleton, spindle . Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Following interaction with TP53BP1, recruited
Protein Description Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. [PubMed: 23333305]
Protein Sequence MTAPGRSPLEPLLETWEDPSVPPGEQTDAYLTLTSRMTGEEGKEVIAEIEKNLSRLYTVLKAHISSQNSELSSAALQALGFCLYNPRITSGLSEANIQELLLTLNGIIKSSDKNVCTRALWVISKQTFPAELVSKMVSSIIDSLEVILSKGEIHSAVVDFEALNVIIRLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIALITEHLMTTKLISELQKLFKNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELGFRSGTPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPQLPANFEQVCVPLIQSTISVDSIPSPQGNSSRGSASPGLSPLTPGHKGASPYGSPRGNLSSNTGGMAAIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLSLEPLEHPLISSPSFFSKYAHTLITAVHDSFVSVGKDASDAVVSAIWKELISLVKSVTEAGNRKEKSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPPKVLGSPAYQVANMDILNGTPALFLIQLIFNNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAFSDSVLTVINQNAKQLVNKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALTLPINHIFSAQTFPTGTMKALLKTWSELYRAFTRCASLVATAEENLCCEELSSKIMCSLEDEVLSDLLFLDRISHIIIVMVDCIDFSPYNKKYQPKIKSPQRSSDWSRKKKEPLGKLASLFKLIVKVIDTFHTLSLKETFSDTLLAIGNSIISMLSNVFGHISLPSMIREIFATFTRPLALLYENSKLDEAPKVYTSLNNKLEKLLGEIVACLQFSYLGAYDSELLEHLSPLLCVIFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKQKILLLLPGLENVEMMDESSEPYSESTENSQLNVKISGMERKSSGKRDSILAHTKDKKKKVKLSAKLKLESSSPKIKSGKLLEEEKSTDFVFIPPEGKETKARVLTEHQKEVLKTKRCDIPALYNNLDASQDTLFSAQFSQEESMESLTLTEKPKEDAKIIKEEQMESTIFIHQDAPENCGIDEHSENASLPNCGGSVAETNPETLITGFDARKEVLISSKILSAESSSSTETSVVSSSSVSNATFSGTPPQPTSRRQTFITLEKFDGSETRPFSPSPLNNISSTVTVRNNQDNTTNTDMPPKARKREVTNSKSDSENLANAGKKSSRRWSKAEQSVTKKSKPSLTSEQEEHSSENNSPDLLSPTEHVSENDDHPSEATLEHKDGDPKPAVENASLEDLTTEEKNVGINMESKESTASVVARTEQIVNEDSQAAALAPNPKTLRRSSRRRSEAVDSCSDSQERESGQQKKERRKEEEKIISKSPLRIKDDKLPTQKLTDESPIQENLTEKGNTLPERTSGEPSVNAEIDQNRRKPDLENVSSEGGGGTLDNLDKSSEKPLRGRTRYQTRRASQGLISAVENSESDSSEAKEEVSRKKRSGKWKNRSSDSVDIEEQEEKKAEEEVMKTANQTLDGQAVPDVDVNAAAQVCEKSTNNNRVILQDSAGPADSLQAPPKGEEKSKINKCVDSSFVSLPVPESNLRTRNASKRLLYKQDNDSNVRVSDSSLSPEKFTQVECQHKRSRRVRRSKSCDCCGEKSQSQEKSFIGLKNTESYAIKSVEKKKTDLQVPETAPETREARDHAETKLAGEEPLVNFHVGLKEENCTTGDSVKSEAELQEASLPPEIVTVKEKTYDTDASEAVSEIQGPCSENHSPAEDPGLSECKDISQKQLSENGELDISDVGKACKVIAGSSPEGVETMELNVRNDAFVAADSEKSTQMDVSVDVATEEDNKKDECEAVTTEVNVEGVATEDFNSGMDLSDTPIPVSKDVETEHAASGEIEGESNESDSGSCEEMNKEMGSHKAQMSTEIDSARVKETDILASASKSEEALIGRLDVNTQSFVSDIEMSSGERTVNCKTETSIELNKLDEAKLSGNEATVGNDTLQEVCFTSEKVEKLPQCLLVQVASELGAESNTTSPEKLELDSFGSVNESPSGMQQARCVWSPLASPSTSILKRGLKRSQEDEISPVNKIRRVSFADPIYQAGLADDIDRRCSVVRSHSSNSSPIIKSVKTSPTSHSKHNTTSAKGFLSPGSQSSKFKSPKKCLITEMAQESMLSPTESVYPALVNCAASVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASEIKTLPIRSPKVFNVKKALRVYHEQQMKSRGLEEIPIFDISEKAVNGVESRTVSTDEERFASDLIEPVTLDTPLSKNLVAQISALALQLDSEDLYSYTGSQLFEMHEKLGTMANSIIRNLQSRWRSPAHENS
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
138PhosphorylationELVSKMVSSIIDSLE
HHHHHHHHHHHHHHH
16.6029895711
139PhosphorylationLVSKMVSSIIDSLEV
HHHHHHHHHHHHHHH
16.5029895711
143PhosphorylationMVSSIIDSLEVILSK
HHHHHHHHHHHHHCC
18.9329895711
247PhosphorylationLFKNKNETYVLKLWP
HHCCCCCHHHHHHHH
28.4625777480
248PhosphorylationFKNKNETYVLKLWPL
HCCCCCHHHHHHHHH
9.5225777480
251UbiquitinationKNETYVLKLWPLFVK
CCCHHHHHHHHHHHH
38.16-
315UbiquitinationPDILCSAKRLKLLMQ
HHHHCCHHHHHHHHH
41.80-
373PhosphorylationQSTISVDSIPSPQGN
HCCCCCCCCCCCCCC
33.9525293948
376PhosphorylationISVDSIPSPQGNSSR
CCCCCCCCCCCCCCC
28.3425293948
381PhosphorylationIPSPQGNSSRGSASP
CCCCCCCCCCCCCCC
28.3925293948
382PhosphorylationPSPQGNSSRGSASPG
CCCCCCCCCCCCCCC
44.6625293948
385PhosphorylationQGNSSRGSASPGLSP
CCCCCCCCCCCCCCC
25.1821082442
387PhosphorylationNSSRGSASPGLSPLT
CCCCCCCCCCCCCCC
22.6226824392
391PhosphorylationGSASPGLSPLTPGHK
CCCCCCCCCCCCCCC
24.6326824392
394PhosphorylationSPGLSPLTPGHKGAS
CCCCCCCCCCCCCCC
30.5225619855
401PhosphorylationTPGHKGASPYGSPRG
CCCCCCCCCCCCCCC
27.5925159016
403PhosphorylationGHKGASPYGSPRGNL
CCCCCCCCCCCCCCC
27.95-
405PhosphorylationKGASPYGSPRGNLSS
CCCCCCCCCCCCCCC
12.9425159016
518PhosphorylationAGNRKEKSGSEVLTL
CCCCCCCCHHHHHHH
48.9527149854
520PhosphorylationNRKEKSGSEVLTLLL
CCCCCCHHHHHHHHH
31.4627149854
524PhosphorylationKSGSEVLTLLLKSLE
CCHHHHHHHHHHHHH
22.1227149854
713PhosphorylationSELYRAFTRCASLVA
HHHHHHHHHHHHHHH
24.6922871156
779PhosphorylationKYQPKIKSPQRSSDW
CCCCCCCCCCCCCCC
29.7323375375
783PhosphorylationKIKSPQRSSDWSRKK
CCCCCCCCCCCHHHC
27.6626745281
784PhosphorylationIKSPQRSSDWSRKKK
CCCCCCCCCCHHHCC
45.3326745281
787PhosphorylationPQRSSDWSRKKKEPL
CCCCCCCHHHCCCCH
38.9326745281
975PhosphorylationNVEMMDESSEPYSES
CCCCCCCCCCCCCCC
35.4223649490
976PhosphorylationVEMMDESSEPYSEST
CCCCCCCCCCCCCCC
40.3126643407
979PhosphorylationMDESSEPYSESTENS
CCCCCCCCCCCCCCC
22.4823984901
980PhosphorylationDESSEPYSESTENSQ
CCCCCCCCCCCCCCC
35.4723649490
982PhosphorylationSSEPYSESTENSQLN
CCCCCCCCCCCCCEE
34.7723984901
983PhosphorylationSEPYSESTENSQLNV
CCCCCCCCCCCCEEE
34.8223984901
986PhosphorylationYSESTENSQLNVKIS
CCCCCCCCCEEEEEE
29.7923984901
1005PhosphorylationKSSGKRDSILAHTKD
CCCCCCCCCEEECCC
24.4325266776
1027PhosphorylationSAKLKLESSSPKIKS
EEEEECCCCCCCCCC
46.6929895711
1028PhosphorylationAKLKLESSSPKIKSG
EEEECCCCCCCCCCC
41.0825263469
1029PhosphorylationKLKLESSSPKIKSGK
EEECCCCCCCCCCCC
39.2226824392
1036AcetylationSPKIKSGKLLEEEKS
CCCCCCCCCCCCCCC
57.927713371
1042AcetylationGKLLEEEKSTDFVFI
CCCCCCCCCCCEEEE
63.037713383
1043PhosphorylationKLLEEEKSTDFVFIP
CCCCCCCCCCEEEEC
36.1723375375
1044PhosphorylationLLEEEKSTDFVFIPP
CCCCCCCCCEEEECC
44.5226239621
1215PhosphorylationQPTSRRQTFITLEKF
CCCCCCCEEEEEEEC
18.3926643407
1218PhosphorylationSRRQTFITLEKFDGS
CCCCEEEEEEECCCC
25.3626643407
1225PhosphorylationTLEKFDGSETRPFSP
EEEECCCCCCCCCCC
37.3223984901
1227PhosphorylationEKFDGSETRPFSPSP
EECCCCCCCCCCCCC
45.3923984901
1231PhosphorylationGSETRPFSPSPLNNI
CCCCCCCCCCCCCCC
27.4425266776
1233PhosphorylationETRPFSPSPLNNISS
CCCCCCCCCCCCCCC
40.6025266776
1251PhosphorylationVRNNQDNTTNTDMPP
EECCCCCCCCCCCCC
29.7030635358
1252PhosphorylationRNNQDNTTNTDMPPK
ECCCCCCCCCCCCCH
42.2330635358
1270PhosphorylationREVTNSKSDSENLAN
CCCCCCCCHHHHHHH
46.3025338131
1272PhosphorylationVTNSKSDSENLANAG
CCCCCCHHHHHHHHC
35.1627841257
1302PhosphorylationKKSKPSLTSEQEEHS
CCCCCCCCCHHHHHC
34.2625338131
1303PhosphorylationKSKPSLTSEQEEHSS
CCCCCCCCHHHHHCC
42.4425338131
1309PhosphorylationTSEQEEHSSENNSPD
CCHHHHHCCCCCCCC
42.5025338131
1310PhosphorylationSEQEEHSSENNSPDL
CHHHHHCCCCCCCCC
46.3725338131
1314PhosphorylationEHSSENNSPDLLSPT
HHCCCCCCCCCCCCC
31.2225338131
1351PhosphorylationKPAVENASLEDLTTE
CCCCCCCCHHHCCCC
43.8221149613
1356PhosphorylationNASLEDLTTEEKNVG
CCCHHHCCCCCCCCC
44.4730635358
1357PhosphorylationASLEDLTTEEKNVGI
CCHHHCCCCCCCCCC
49.8230635358
1379PhosphorylationTASVVARTEQIVNED
CHHHHHHHHHHHCCC
23.6225619855
1387PhosphorylationEQIVNEDSQAAALAP
HHHHCCCHHHHHHCC
18.6226824392
1407PhosphorylationRRSSRRRSEAVDSCS
HHHHHHHHHHHHHCC
28.2627087446
1412PhosphorylationRRSEAVDSCSDSQER
HHHHHHHHCCHHHHH
14.6625266776
1414PhosphorylationSEAVDSCSDSQERES
HHHHHHCCHHHHHHH
44.2225159016
1416PhosphorylationAVDSCSDSQERESGQ
HHHHCCHHHHHHHHH
20.0425159016
1437PhosphorylationKEEEKIISKSPLRIK
HHHHHHHCCCCCCCC
30.4725159016
1439PhosphorylationEEKIISKSPLRIKDD
HHHHHCCCCCCCCCC
23.5226824392
1454PhosphorylationKLPTQKLTDESPIQE
CCCCCCCCCCCCCHH
44.7726239621
1457PhosphorylationTQKLTDESPIQENLT
CCCCCCCCCCHHCCC
30.0726824392
1498PhosphorylationPDLENVSSEGGGGTL
CCHHCCCCCCCCCCC
35.66-
1504PhosphorylationSSEGGGGTLDNLDKS
CCCCCCCCCCCCCCC
33.9219854140
1511PhosphorylationTLDNLDKSSEKPLRG
CCCCCCCCCCCCCCC
43.3121082442
1528PhosphorylationRYQTRRASQGLISAV
HHHHHHHHHHHHHHH
23.9925521595
1533PhosphorylationRASQGLISAVENSES
HHHHHHHHHHHCCCC
31.1625619855
1538PhosphorylationLISAVENSESDSSEA
HHHHHHCCCCCCHHH
25.6021082442
1540PhosphorylationSAVENSESDSSEAKE
HHHHCCCCCCHHHHH
42.4821082442
1542PhosphorylationVENSESDSSEAKEEV
HHCCCCCCHHHHHHH
39.0821082442
1543PhosphorylationENSESDSSEAKEEVS
HCCCCCCHHHHHHHH
46.7121082442
1550PhosphorylationSEAKEEVSRKKRSGK
HHHHHHHHHHHHCCC
41.4821149613
1562PhosphorylationSGKWKNRSSDSVDIE
CCCCCCCCCCCCCHH
48.1427087446
1563PhosphorylationGKWKNRSSDSVDIEE
CCCCCCCCCCCCHHH
30.5722942356
1565PhosphorylationWKNRSSDSVDIEEQE
CCCCCCCCCCHHHHH
24.5225521595
1572PhosphorylationSVDIEEQEEKKAEEE
CCCHHHHHHHHHHHH
75.0624719451
1644PhosphorylationKINKCVDSSFVSLPV
HHCHHCCCCCCCCCC
12.7923984901
1645PhosphorylationINKCVDSSFVSLPVP
HCHHCCCCCCCCCCC
25.7923984901
1648PhosphorylationCVDSSFVSLPVPESN
HCCCCCCCCCCCHHH
25.5823984901
1678PhosphorylationNDSNVRVSDSSLSPE
CCCCCEECCCCCCHH
22.6225619855
1680PhosphorylationSNVRVSDSSLSPEKF
CCCEECCCCCCHHHC
26.1825619855
1681PhosphorylationNVRVSDSSLSPEKFT
CCEECCCCCCHHHCC
37.5522942356
1683PhosphorylationRVSDSSLSPEKFTQV
EECCCCCCHHHCCCC
32.7227087446
1688PhosphorylationSLSPEKFTQVECQHK
CCCHHHCCCCCCHHH
42.6525619855
1703PhosphorylationRSRRVRRSKSCDCCG
CCCCCHHCCCCCCCC
20.5325266776
1705PhosphorylationRRVRRSKSCDCCGEK
CCCHHCCCCCCCCCC
19.2125266776
1719PhosphorylationKSQSQEKSFIGLKNT
CCCCCCCCCCCCCCC
22.7319367708
1728PhosphorylationIGLKNTESYAIKSVE
CCCCCCCCEEEEECC
20.1628059163
1760AcetylationARDHAETKLAGEEPL
HHHHHHHHHCCCCCC
28.0415284967
1780PhosphorylationGLKEENCTTGDSVKS
ECCCCCCCCCCCCCC
45.45-
1784PhosphorylationENCTTGDSVKSEAEL
CCCCCCCCCCCHHHH
32.5627841257
1795PhosphorylationEAELQEASLPPEIVT
HHHHHHCCCCCCEEE
40.4327566939
1810PhosphorylationVKEKTYDTDASEAVS
EEEEECCCCHHHHHH
24.0523984901
1813PhosphorylationKTYDTDASEAVSEIQ
EECCCCHHHHHHHCC
28.9723984901
1817PhosphorylationTDASEAVSEIQGPCS
CCHHHHHHHCCCCCC
35.7123984901
1824PhosphorylationSEIQGPCSENHSPAE
HHCCCCCCCCCCCCC
44.5621149613
1828PhosphorylationGPCSENHSPAEDPGL
CCCCCCCCCCCCCCH
37.0721149613
1836PhosphorylationPAEDPGLSECKDISQ
CCCCCCHHHCCCCCH
47.0323984901
1842PhosphorylationLSECKDISQKQLSEN
HHHCCCCCHHHHCCC
41.27-
1855PhosphorylationENGELDISDVGKACK
CCCCCCHHHHHHHCC
26.3826745281
1867PhosphorylationACKVIAGSSPEGVET
HCCEEECCCCCCCCE
33.4326824392
1868PhosphorylationCKVIAGSSPEGVETM
CCEEECCCCCCCCEE
26.5026824392
1874PhosphorylationSSPEGVETMELNVRN
CCCCCCCEEEEEECC
17.3428833060
1931PhosphorylationVATEDFNSGMDLSDT
EECCCCCCCCCCCCC
35.17-
1960PhosphorylationSGEIEGESNESDSGS
CCEECCCCCCCCCCC
57.6725619855
1963PhosphorylationIEGESNESDSGSCEE
ECCCCCCCCCCCHHH
41.1325619855
1965PhosphorylationGESNESDSGSCEEMN
CCCCCCCCCCHHHHH
41.7225619855
1967PhosphorylationSNESDSGSCEEMNKE
CCCCCCCCHHHHHHH
23.4729514104
2038PhosphorylationVNCKTETSIELNKLD
EECEECCEEEECCCC
14.0827841257
2090PhosphorylationASELGAESNTTSPEK
HHHHCCCCCCCCHHH
38.6518846507
2092PhosphorylationELGAESNTTSPEKLE
HHCCCCCCCCHHHHC
37.6218846507
2093PhosphorylationLGAESNTTSPEKLEL
HCCCCCCCCHHHHCC
46.6818846507
2094PhosphorylationGAESNTTSPEKLELD
CCCCCCCCHHHHCCC
29.0821149613
2109PhosphorylationSFGSVNESPSGMQQA
CCCCCCCCCCHHHHH
21.1127841257
2121PhosphorylationQQARCVWSPLASPST
HHHEEEECCCCCCCH
6.9422942356
2125PhosphorylationCVWSPLASPSTSILK
EEECCCCCCCHHHHH
27.3722942356
2127PhosphorylationWSPLASPSTSILKRG
ECCCCCCCHHHHHHH
32.0925159016
2128PhosphorylationSPLASPSTSILKRGL
CCCCCCCHHHHHHHH
24.1425159016
2129PhosphorylationPLASPSTSILKRGLK
CCCCCCHHHHHHHHC
30.2025159016
2138PhosphorylationLKRGLKRSQEDEISP
HHHHHCCCCCCCCCC
36.0122802335
2144PhosphorylationRSQEDEISPVNKIRR
CCCCCCCCCCHHCCE
22.2826824392
2153PhosphorylationVNKIRRVSFADPIYQ
CHHCCEEECCCHHHH
16.9525159016
2159PhosphorylationVSFADPIYQAGLADD
EECCCHHHHCCCHHH
9.5625159016
2176PhosphorylationRRCSVVRSHSSNSSP
HCHHHEECCCCCCCC
18.9923984901
2178PhosphorylationCSVVRSHSSNSSPII
HHHEECCCCCCCCCE
32.2524759943
2179PhosphorylationSVVRSHSSNSSPIIK
HHEECCCCCCCCCEE
34.9929895711
2181PhosphorylationVRSHSSNSSPIIKSV
EECCCCCCCCCEEEE
39.1629895711
2182PhosphorylationRSHSSNSSPIIKSVK
ECCCCCCCCCEEEEE
25.1125266776
2190PhosphorylationPIIKSVKTSPTSHSK
CCEEEEECCCCCCCC
37.4725266776
2191PhosphorylationIIKSVKTSPTSHSKH
CEEEEECCCCCCCCC
22.0627149854
2208PhosphorylationTSAKGFLSPGSQSSK
CCCCCCCCCCCCCCC
25.5922942356
2211PhosphorylationKGFLSPGSQSSKFKS
CCCCCCCCCCCCCCC
30.2123984901
2213PhosphorylationFLSPGSQSSKFKSPK
CCCCCCCCCCCCCCC
36.8723984901
2214PhosphorylationLSPGSQSSKFKSPKK
CCCCCCCCCCCCCCC
34.1823984901
2283PhosphorylationKTIGDLSTLTASEIK
EEECCHHCCCHHHCC
35.1128066266
2285PhosphorylationIGDLSTLTASEIKTL
ECCHHCCCHHHCCCC
28.3828066266
2287PhosphorylationDLSTLTASEIKTLPI
CHHCCCHHHCCCCCC
34.3225266776
2290UbiquitinationTLTASEIKTLPIRSP
CCCHHHCCCCCCCCC
39.70-
2296PhosphorylationIKTLPIRSPKVFNVK
CCCCCCCCCCCCCHH
29.7725159016
2298UbiquitinationTLPIRSPKVFNVKKA
CCCCCCCCCCCHHHH
61.78-
2330UbiquitinationPIFDISEKAVNGVES
CCEECCHHHHCCCCC
51.33-
2341PhosphorylationGVESRTVSTDEERFA
CCCCCCCCCCHHHHH
29.54-
2413PhosphorylationNLQSRWRSPAHENS-
HHHHHHCCCCCCCC-
21.34-
2419PhosphorylationRSPAHENS-------
CCCCCCCC-------
38.32-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIF1_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIF1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIF1_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
NANOG_MOUSENanogphysical
17093407

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIF1_MOUSE

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Related Literatures of Post-Translational Modification

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