LMBL2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LMBL2_MOUSE
• UniProt AC: P59178
• Protein Name: Lethal(3)malignant brain tumor-like protein 2
• Gene Name: L3mbtl2
• Organism: Mus musculus (Mouse).
• Sequence Length: 703
• Subcellular Localization: Nucleus .
• Protein Description: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27' (By similarity)..
• Protein Sequence: MEKPRGTEEAPSSEPMEEEEEDDLDLFGGYDSFRSYNSSAGSESSSYLEESSEAENEDREAGELPTSPLHLFSSANNRSLDGSGSEPAVCEMCGIVGTREAFFSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLHKAAWSAKIGAFLHAQGTGQLADGTPTGQDALVLGFDWGKFLKDHSYKAAPVSCFKHVPLYDQWEDVMKGMKVEVLNSDAVLPSRVYWIATVIQAAGYRVLLRYEGFENDASHDFWCNLGTVDVHPIGWCAINSKILVPPRTIHAKFTDWKSYLMKRLVGSRTLPADFHIKMVESMKYPFRQGMRLEVVDKTQVSRTRMAVVDTVIGGRLRLLYEDGDSDDDFWCHMWSPLIHPVGWSRRVGHGIKMSDRRCDMSHHPTFRKIYCDAVPYLFKKVRAVYTEGGWFEEGMKLEAIDPLNLGSICVATICKVLLDGYLMICVDGGPSTDGSDWFCYHASSHAIFPATFCQKNDIELTPPKGYETQPFAWETYLEKTKSKAAPARLFNMDCPNHGFKVGMKLEAVDLMEPRLICVATVKRVVHRLLSIHFDGWDNEYDQWVDCESPDIYPVGWCELTGYQLQPPVSAEPNTPQKGKDTTKKKKKQFGKKRKRIPSAKTRPLRQGSKKPLLEDNLEALGVSEPVPDDIIAVCVKEEHQDISSLDRSPSPQLPLPIESIKQERNN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RGTEEAPSSEPMEEE CCCCCCCCCCCCCHH	55.15	25338131
13	Phosphorylation	GTEEAPSSEPMEEEE CCCCCCCCCCCCHHH	44.66	-
36	Phosphorylation	GYDSFRSYNSSAGSE CHHHHHHCCCCCCCC	18.14	-
38	Phosphorylation	DSFRSYNSSAGSESS HHHHHCCCCCCCCCH	17.21	-
66	Phosphorylation	REAGELPTSPLHLFS CCCCCCCCCHHEEEE	56.45	24704852
67	Phosphorylation	EAGELPTSPLHLFSS CCCCCCCCHHEEEEC	24.43	26824392
73	Phosphorylation	TSPLHLFSSANNRSL CCHHEEEECCCCCCC	34.60	25367039
74	Phosphorylation	SPLHLFSSANNRSLD CHHEEEECCCCCCCC	27.90	25367039
79	Phosphorylation	FSSANNRSLDGSGSE EECCCCCCCCCCCCC	32.70	22006019
83	Phosphorylation	NNRSLDGSGSEPAVC CCCCCCCCCCCCHHH	38.52	22006019
161	Phosphorylation	AFLHAQGTGQLADGT HHHHHCCCCCCCCCC	15.07	25159016
168	Phosphorylation	TGQLADGTPTGQDAL CCCCCCCCCCCCCEE	20.44	25159016
221	Phosphorylation	MKVEVLNSDAVLPSR CEEEEECCCCCCHHH	23.84	26239621
227	Phosphorylation	NSDAVLPSRVYWIAT CCCCCCHHHHHHHHH	30.16	26239621
230	Phosphorylation	AVLPSRVYWIATVIQ CCCHHHHHHHHHHHH	7.03	26239621
234	Phosphorylation	SRVYWIATVIQAAGY HHHHHHHHHHHHCCC	14.70	26239621
318	Phosphorylation	FHIKMVESMKYPFRQ CEEHHHHHCCCCCCC	14.79	28059163
321	Phosphorylation	KMVESMKYPFRQGMR HHHHHCCCCCCCCCE	10.04	-
335	Phosphorylation	RLEVVDKTQVSRTRM EEEEECCCCCCCCEE	29.73	25619855
338	Phosphorylation	VVDKTQVSRTRMAVV EECCCCCCCCEEEEE	20.37	25619855
635	Phosphorylation	KKRKRIPSAKTRPLR CCCCCCCCCCCCCCC	39.77	24719451
680	Phosphorylation	KEEHQDISSLDRSPS CHHCCCHHHCCCCCC	32.89	25159016
681	Phosphorylation	EEHQDISSLDRSPSP HHCCCHHHCCCCCCC	34.32	25159016
685	Phosphorylation	DISSLDRSPSPQLPL CHHHCCCCCCCCCCC	29.42	27818261
687	Phosphorylation	SSLDRSPSPQLPLPI HHCCCCCCCCCCCCH	26.90	25521595
696	Phosphorylation	QLPLPIESIKQERNN CCCCCHHHHHHHHCC	35.49	25159016

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LMBL2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LMBL2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LMBL2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHD4_MOUSE	Chd4	physical	22770845
MTA2_MOUSE	Mta2	physical	22770845
HDAC1_MOUSE	Hdac1	physical	22770845
P66A_MOUSE	Gatad2a	physical	22770845
MBD3_MOUSE	Mbd3	physical	22770845
MTA3_MOUSE	Mta3	physical	22770845
HDAC2_MOUSE	Hdac2	physical	22770845
RBBP4_MOUSE	Rbbp4	physical	22770845
RBBP7_MOUSE	Rbbp7	physical	22770845
P66B_MOUSE	Gatad2b	physical	22770845
MGAP_MOUSE	Mga	physical	22770845
E2F6_MOUSE	E2f6	physical	22770845
PCGF6_MOUSE	Pcgf6	physical	22770845
RING2_MOUSE	Rnf2	physical	22770845
TFDP1_MOUSE	Tfdp1	physical	22770845
RYBP_MOUSE	Rybp	physical	22770845
KDM5C_MOUSE	Kdm5c	physical	22770845
EHMT2_MOUSE	Ehmt2	physical	22770845
REST_MOUSE	Rest	physical	22770845
ERR2_MOUSE	Esrrb	physical	22770845
SALL4_MOUSE	Sall4	physical	22770845
PO5F1_MOUSE	Pou5f1	physical	22770845
NACC1_MOUSE	Nacc1	physical	22770845
LIN54_MOUSE	Lin54	physical	22770845
MBB1A_MOUSE	Mybbp1a	physical	22770845
TIF1B_MOUSE	Trim28	physical	22770845
RIF1_MOUSE	Rif1	physical	22770845
SMC1A_MOUSE	Smc1a	physical	22770845
SMC3_MOUSE	Smc3	physical	22770845
SIN3A_MOUSE	Sin3a	physical	22770845
SMCA4_MOUSE	Smarca4	physical	22770845
SMRC1_MOUSE	Smarcc1	physical	22770845
WDR5_MOUSE	Wdr5	physical	22770845
HELLS_MOUSE	Hells	physical	22770845
SMCA5_MOUSE	Smarca5	physical	22770845
CBX1_MOUSE	Cbx1	physical	22770845
E2F6_HUMAN	E2F6	physical	26496610
HDAC1_HUMAN	HDAC1	physical	26496610
HDAC2_HUMAN	HDAC2	physical	26496610
TFDP1_HUMAN	TFDP1	physical	26496610
TTF1_HUMAN	TTF1	physical	26496610
WDR5_HUMAN	WDR5	physical	26496610
MGAP_HUMAN	MGA	physical	26496610
TXD11_HUMAN	TXNDC11	physical	26496610
TLN2_HUMAN	TLN2	physical	26496610
PCGF6_HUMAN	PCGF6	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.