MBD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBD3_MOUSE
• UniProt AC: Q9Z2D8
• Protein Name: Methyl-CpG-binding domain protein 3
• Gene Name: Mbd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 285
• Subcellular Localization: Nucleus . Chromosome. Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci..
• Protein Description: Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases..
• Protein Sequence: MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEEEEEEEEEEEEPEPERV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5 (in isoform 2)	Phosphorylation	-	40.42	29895711
7 (in isoform 2)	Phosphorylation	-	34.36	25266776
24	Phosphorylation	REEVPRRSGLSAGHR HHCCCCCCCCCCCCC	45.42	22817900
35	Phosphorylation	AGHRDVFYYSPSGKK CCCCCEEEECCCCCC	11.68	26643407
36	Phosphorylation	GHRDVFYYSPSGKKF CCCCEEEECCCCCCC	11.57	24759943
37	Phosphorylation	HRDVFYYSPSGKKFR CCCEEEECCCCCCCC	10.95	26643407
39	Phosphorylation	DVFYYSPSGKKFRSK CEEEECCCCCCCCCC	58.25	28066266
52	Phosphorylation	SKPQLARYLGGSMDL CCHHHHHHHCCCCCC	12.23	28833060
56	Phosphorylation	LARYLGGSMDLSTFD HHHHHCCCCCCCCCC	13.81	26824392
60	Phosphorylation	LGGSMDLSTFDFRTG HCCCCCCCCCCHHHH	23.82	28066266
61	Phosphorylation	GGSMDLSTFDFRTGK CCCCCCCCCCHHHHH	34.22	28833060
66	Phosphorylation	LSTFDFRTGKMLMNK CCCCCHHHHHHHHHH	40.94	23984901
77	Ubiquitination	LMNKMNKSRQRVRYD HHHHHHHHCCCCCCC	28.74	27667366
83	Phosphorylation	KSRQRVRYDSSNQVK HHCCCCCCCCCCCCC	19.81	28285833
85	Phosphorylation	RQRVRYDSSNQVKGK CCCCCCCCCCCCCCC	23.43	27087446
86	Phosphorylation	QRVRYDSSNQVKGKP CCCCCCCCCCCCCCC	28.52	27566939
97	Ubiquitination	KGKPDLNTALPVRQT CCCCCHHCCCCHHHH	36.55	27667366
105	Ubiquitination	ALPVRQTASIFKQPV CCCHHHHHHHHHCCC	7.71	27667366
109	Ubiquitination	RQTASIFKQPVTKIT HHHHHHHHCCCEECC	52.61	27667366
125	Ubiquitination	HPSNKVKSDPQKAVD CCCCCCCCCHHHHCC	58.47	27667366
129	Ubiquitination	KVKSDPQKAVDQPRQ CCCCCHHHHCCCHHH	56.62	27667366
137	Ubiquitination	AVDQPRQLFWEKKLS HCCCHHHHHHHHHHC	5.94	27667366
144	Phosphorylation	LFWEKKLSGLSAFDI HHHHHHHCCCCHHHH	46.71	26239621
147	Phosphorylation	EKKLSGLSAFDIAEE HHHHCCCCHHHHHHH	30.34	26239621
157	Ubiquitination	DIAEELVRTMDLPKG HHHHHHHHHCCCCCC	36.64	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBD3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBD3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DNM3A_HUMAN	DNMT3A	physical	16322236
SMCA4_HUMAN	SMARCA4	physical	16322236

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.