KDM5C_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDM5C_MOUSE
• UniProt AC: P41230
• Protein Name: Lysine-specific demethylase 5C
• Gene Name: Kdm5c
• Organism: Mus musculus (Mouse).
• Sequence Length: 1554
• Subcellular Localization: Nucleus .
• Protein Description: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements (By similarity). Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2..
• Protein Sequence: MELGSDDFLPPPECPVFEPSWAEFRDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEVDNFRFTPRIQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERRILDLYSLSKIVVEEGGYETICKDRRWARVAQRLNYPPGKNIGSLLRSHYERIVYPYEMYQSGANLVQCNTRPFDNEEKDKEYKPHSIPLRQSVQPSKFNSYGRRAKRLQPDPEPTEEDIEKNPELKKLQIYGAGPKMMGLGLMAKDKTLRKKDKEGPECPPTVVVKEELGGDVKMESTSPKTFLEGKEELSHSPEPCTKMTMRLRRNHSNAQFIESYVCRMCSRGDEDDKLLLCDGCDDNYHIFCLLPPLPEIPKGVWRCPKCVMAECKRPPEAFGFEQATREYTLQSFGEMADSFKADYFNMPVHMVPTELVEKEFWRLVNSIEEDVTVEYGADIHSKEFGSGFPVSDSKRHLTPEEEEYATSGWNLNVMPVLEQSVLCHINADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMKKLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYNFAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAACPEKLDLNLAAAVHKEMFIMVQEERRLRKALLEKGITEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVCLSHINDLCKCSSSRQYLRYRYTLDELPAMLHKLKVRAESFDTWANKVRVALEVEDGRKRSLEELRALESEARERRFPNSELLQRLKNCLSEAEACVSRALGLVSGQEAGPDRVAGLQMTLAELRDFLGQMNNLPCAMHQIGDVKGILEQVEAYQTEAREALVSQPSSPGLLQSLLERGQQLGVEVPEAQQLQRQVEQARWLDEVKRTLAPSARRGTLAIMRGLLVAGASVAPSPAVDKAQAELQELLTIAERWEEKAHLCLEARQKHPPATLEAIIHEAENIPVHLPNIQSLKEALAKARAWIADVDEIQNGDHYPCLDDLEGLVAVGRDLPVGLEELRQLELQVLTAHSWREKASKTFLKKNSCYTLLEVLCPCADAGSDSTKRSRWMEKELGLYKSDTELLGLSAQDLRDPGSVIVAFKEGEQKEKEGILQLRRTNSAKPSPLALLTTASSTASICVCGQVPAGVGALQCDLCQDWFHGRCVTVPRLLSSQRSSLPSSPLLAWWEWDTKFLCPLCMRSRRPRLETILALLVALQRLPVRLPEGEALQCLTERAISWQGRARQVLASEEVTALLGRLAELRQRLQAESKPEESLAYPSDGGEGTGNMPKVQGLLENGDSVTSPEKVATEEGSGKRDLELLSSILPQLSGPVLELPEATRAPLEELMMEGDLLEVTLDENHSIWQLLQAGQPPDLKRVQTLLELEKAERHGSRTRGRALERRRRRKVDRGGEPDDPAREELEPKRVRSSGPEAEEVQEEEELEEETGGEVPPVPFPNSGSPSIQEDQDGLEPVLEAGSDTSAPFSTLTSRLLMSCPQQPSLQQL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
30	Phosphorylation	EFRDPLGYIAKIRPI HHCCCCHHHCEECCC	12.85	28059163
82	Ubiquitination	LEAQTRVKLNYLDQI HHHHHHHHHHHHHHH	27.94	-
151	Phosphorylation	PPGKNIGSLLRSHYE CCCCCHHHHHHHHHH	22.04	22942356
239	Phosphorylation	ELKKLQIYGAGPKMM HHHHEEEECCCCCHH	6.48	22817900
285	Phosphorylation	GGDVKMESTSPKTFL CCCCEEEECCCCCHH	30.59	23567750
286	Phosphorylation	GDVKMESTSPKTFLE CCCEEEECCCCCHHC	35.42	23567750
287	Phosphorylation	DVKMESTSPKTFLEG CCEEEECCCCCHHCC	33.41	25338131
290	Phosphorylation	MESTSPKTFLEGKEE EEECCCCCHHCCCHH	36.52	23984901
299	Phosphorylation	LEGKEELSHSPEPCT HCCCHHHCCCCCCCC	25.79	25159016
301	Phosphorylation	GKEELSHSPEPCTKM CCHHHCCCCCCCCHH	27.81	27087446
306	Phosphorylation	SHSPEPCTKMTMRLR CCCCCCCCHHHHHHH	34.27	25159016
309	Phosphorylation	PEPCTKMTMRLRRNH CCCCCHHHHHHHHCC	10.74	27841257
317	Phosphorylation	MRLRRNHSNAQFIES HHHHHCCCCHHHHHH	37.09	26824392
408	Phosphorylation	ADSFKADYFNMPVHM HHHHCCCCCCCCCCC	11.17	-
751	Phosphorylation	RQYLRYRYTLDELPA CCHHHHEEEHHHHHH	11.61	21183079
790	Phosphorylation	VEDGRKRSLEELRAL ECCCCCCCHHHHHHH	43.07	-
893	Phosphorylation	EAREALVSQPSSPGL HHHHHHHHCCCCHHH	36.90	22942356
896	Phosphorylation	EALVSQPSSPGLLQS HHHHHCCCCHHHHHH	41.34	27566939
897	Phosphorylation	ALVSQPSSPGLLQSL HHHHCCCCHHHHHHH	29.66	27087446
903	Phosphorylation	SSPGLLQSLLERGQQ CCHHHHHHHHHHHHH	34.59	25159016
1086	Phosphorylation	HSWREKASKTFLKKN CHHHHHHHHHHHHHC	43.21	-
1114	Ubiquitination	DAGSDSTKRSRWMEK CCCCCCHHHHHHHHH	52.94	-
1329	Phosphorylation	EESLAYPSDGGEGTG HHHCCCCCCCCCCCC	35.89	25338131
1350	Phosphorylation	GLLENGDSVTSPEKV HHHHCCCCCCCHHHH	28.79	27087446
1352	Phosphorylation	LENGDSVTSPEKVAT HHCCCCCCCHHHHHC	42.38	26745281
1353	Phosphorylation	ENGDSVTSPEKVATE HCCCCCCCHHHHHCC	28.98	27087446
1536	Phosphorylation	DTSAPFSTLTSRLLM CCCCCCHHHHHHHHH	34.14	27149854

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDM5C_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDM5C_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDM5C_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of KDM5C_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.