HELLS_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HELLS_MOUSE
• UniProt AC: Q60848
• Protein Name: Lymphocyte-specific helicase
• Gene Name: Hells {ECO:0000312|MGI:MGI:106209}
• Organism: Mus musculus (Mouse).
• Sequence Length: 821
• Subcellular Localization: Nucleus . Closely associated with pericentric heterochromatin.
• Protein Description: Plays an essential role in normal development and survival. Involved in regulation of the expansion or survival of lymphoid cells. Required for de novo or maintenance DNA methylation. May control silencing of the imprinted CDKN1C gene through DNA methylation. May play a role in formation and organization of heterochromatin, implying a functional role in the regulation of transcription and mitosis..
• Protein Sequence: MAEQTEPAVITPAMLEEEEQLEAAGLEKERKMLEEAQKSWDRESTEIRYRRLQHLLEKSNIYSKFLLTKMEQQQLEEQKKKEKLEKKKRSLKLTEGKSLVDGNGEKPVMKKKRGREDESYNISEVMSKEEILSVAKKHKDNEDESSSTTSLCVEDIQKNKDSNSMIKDRLSQTVRQNSKFFFDPVRKCNGQPVPFQQPKHFTGGVMRWYQVEGMEWLRMLWENGINGILADEMGLGKTVQCIATIALMIQRGVPGPFLVCGPLSTLPNWMAEFKRFTPEIPTLLYHGTREDRRKLVKNIHKRQGTLQIHPVVVTSFEIAMRDQNALQHCYWKYLIVDEGHRIKNMKCRLIRELKRFNADNKLLLTGTPLQNNLSELWSLLNFLLPDVFDDLKSFESWFDITSLSETAEDIIAKEREQNVLHMLHQILTPFLLRRLKSDVALEVPPKREVVVYAPLCNKQEIFYTAIVNRTIANMFGSCEKETVELSPTGRPKRRSRKSINYSELDQFPSELEKLISQIQPEVNRERTVVEGNIPIESEVNLKLRNIMMLLRKCCNHPYMIEYPIDPVTQEFKIDEELVTNSGKFLILDRMLPELKKRGHKVLVFSQMTSMLDILMDYCHLRNFIFSRLDGSMSYSEREKNIYSFNTDPDVFLFLVSTRAGGLGINLTAADTVIIYDSDWNPQSDLQAQDRCHRIGQTKPVVVYRLVTANTIDQKIVERAAAKRKLEKLIIHKNHFKGGQSGLSQSKNFLDAKELMELLKSRDYEREVKGSREKVISDEDLELLLDRSDLIDQMKASRPIKGKTGIFKILENSEDSSAECLF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MAEQTEPAVITP ---CCCCCCCCCCCH	35.13	21454597
11	Phosphorylation	QTEPAVITPAMLEEE CCCCCCCCHHHHCHH	9.82	21454597
39	Phosphorylation	MLEEAQKSWDRESTE HHHHHHHHCCHHHHH	23.33	24719451
49	Phosphorylation	RESTEIRYRRLQHLL HHHHHHHHHHHHHHH	13.02	24719451
90	Phosphorylation	KLEKKKRSLKLTEGK HHHHHHHHCCCCCCC	38.44	-
98	Phosphorylation	LKLTEGKSLVDGNGE CCCCCCCCCCCCCCC	44.47	28973931
171	Phosphorylation	SMIKDRLSQTVRQNS HHHHHHHHHHHHHCC	25.38	-
178	Phosphorylation	SQTVRQNSKFFFDPV HHHHHHCCCCCCCCC	23.62	24719451
452	Phosphorylation	PKREVVVYAPLCNKQ CCCEEEEEEECCCCH	7.29	22817900
458	Ubiquitination	VYAPLCNKQEIFYTA EEEECCCCHHHHHHH	48.59	-
482	Phosphorylation	FGSCEKETVELSPTG HCCCEEEEEECCCCC	30.28	25777480
486	Phosphorylation	EKETVELSPTGRPKR EEEEEECCCCCCCCC	13.60	26824392
488	Phosphorylation	ETVELSPTGRPKRRS EEEECCCCCCCCCCC	42.31	25159016
495	Phosphorylation	TGRPKRRSRKSINYS CCCCCCCCCCCCCHH	48.36	25338131
498	Phosphorylation	PKRRSRKSINYSELD CCCCCCCCCCHHHHH	18.24	26824392
501	Phosphorylation	RSRKSINYSELDQFP CCCCCCCHHHHHCCH	11.23	25619855
502	Phosphorylation	SRKSINYSELDQFPS CCCCCCHHHHHCCHH	27.48	25619855
542	Ubiquitination	IESEVNLKLRNIMML CCCHHHHHHHHHHHH	39.95	-
763	Phosphorylation	ELLKSRDYEREVKGS HHHHCCCHHHHCCCC	18.77	23926118
812	Phosphorylation	IFKILENSEDSSAEC CEEHHCCCCCCCCCC	33.15	25619855
815	Phosphorylation	ILENSEDSSAECLF- HHCCCCCCCCCCCC-	27.65	25619855
816	Phosphorylation	LENSEDSSAECLF-- HCCCCCCCCCCCC--	40.17	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HELLS_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HELLS_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HELLS_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of HELLS_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.