MTA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MTA3_MOUSE
• UniProt AC: Q924K8
• Protein Name: Metastasis-associated protein MTA3
• Gene Name: Mta3
• Organism: Mus musculus (Mouse).
• Sequence Length: 591
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity)..
• Protein Sequence: MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTASGNVEAKVVCFYRRRDISNTLIMLADKHAKETEEESETPVEADLTEKQKHQLKHRELFLSRQYESLPATHIRGKCSVALLNETESVLSYLDKEDTFFYSLVYDPSVKTLLADKGEIRVGPKYQADIPDMLPEDSDEREQSKLEVKVWDPNSPLTDRQIDQFLVVARAVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLYRHGYDLSSAISVLVPLGGPVLCRDEMEEWSASEACLFEEALEKYGKDFNDIRQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPTYKPNPNQISSSNGKAGTVNGAVGTQFQPQSALLGRACESCYATQSHQWYSWGPPNMQCRLCATCWLYWKKYGGLKMPTQSDEEKSPSPTAEDPRARSHMSRQALQGMPVRNTGSPKSAVKTRQAFFLRTTYFTKIARQVCKSTLRLRQAARRPFVAINYAAIRAEYADRHAELSGSPLKSRSTRKPLSCIIGYLEIHPAKKPNVIRSPPSLQTPATKRMLAAPNHTSLSILGKRNYSHHNGLDGPERWLSR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Ubiquitination	RRIEELNKTASGNVE HHHHHHHCCCCCCCE	59.08	22790023
35	Phosphorylation	EELNKTASGNVEAKV HHHHCCCCCCCEEEE	35.81	29895711
66	Phosphorylation	ADKHAKETEEESETP HHHHHHHCHHHCCCC	48.25	30635358
70	Phosphorylation	AKETEEESETPVEAD HHHCHHHCCCCCCCC	50.48	30635358
72	Phosphorylation	ETEEESETPVEADLT HCHHHCCCCCCCCCC	41.74	30635358
81	Ubiquitination	VEADLTEKQKHQLKH CCCCCCHHHHHHHHH	60.45	-
83	Ubiquitination	ADLTEKQKHQLKHRE CCCCHHHHHHHHHHH	44.37	-
219	Phosphorylation	SSSVRQPSLHMSAAA CCCCCCCCHHHHHHH	23.67	27566939
223	Phosphorylation	RQPSLHMSAAAASRD CCCCHHHHHHHHHCC	12.19	-
418	Phosphorylation	YGGLKMPTQSDEEKS HCCCCCCCCCCCCCC	36.89	26239621
420	Phosphorylation	GLKMPTQSDEEKSPS CCCCCCCCCCCCCCC	49.85	23984901
425	Phosphorylation	TQSDEEKSPSPTAED CCCCCCCCCCCCCCC	33.61	25521595
427	Phosphorylation	SDEEKSPSPTAEDPR CCCCCCCCCCCCCHH	41.81	25521595
429	Phosphorylation	EEKSPSPTAEDPRAR CCCCCCCCCCCHHHH	47.20	25521595
452	Phosphorylation	QGMPVRNTGSPKSAV CCCCCCCCCCCHHHH	28.59	26745281
454	Phosphorylation	MPVRNTGSPKSAVKT CCCCCCCCCHHHHHH	27.41	26745281
514	Phosphorylation	ADRHAELSGSPLKSR HHHHHHHCCCCCCCC	28.82	26824392
516	Phosphorylation	RHAELSGSPLKSRST HHHHHCCCCCCCCCC	24.55	25521595
520	Phosphorylation	LSGSPLKSRSTRKPL HCCCCCCCCCCCCCC	38.86	25367039
547	Phosphorylation	KKPNVIRSPPSLQTP CCCCCCCCCCCCCCC	30.00	26824392
550	Phosphorylation	NVIRSPPSLQTPATK CCCCCCCCCCCCCHH	36.17	25521595
553	Phosphorylation	RSPPSLQTPATKRML CCCCCCCCCCHHHCC	21.86	26643407
556	Phosphorylation	PSLQTPATKRMLAAP CCCCCCCHHHCCCCC	22.01	26643407
566	Phosphorylation	MLAAPNHTSLSILGK CCCCCCCCCCHHCCC	37.69	21189417
567	Phosphorylation	LAAPNHTSLSILGKR CCCCCCCCCHHCCCC	16.75	21189417
576	Phosphorylation	SILGKRNYSHHNGLD HHCCCCCCCCCCCCC	17.26	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MTA3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MTA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MTA3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of MTA3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.