E2F6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: E2F6_MOUSE
• UniProt AC: O54917
• Protein Name: Transcription factor E2F6
• Gene Name: E2f6
• Organism: Mus musculus (Mouse).
• Sequence Length: 272
• Subcellular Localization: Nucleus .
• Protein Description: Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity)..
• Protein Sequence: MSQQRTARRQPSLLVDPAQETVRRRCRDPINVENLLPSKIRINLEENVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIELVEKKSKNHIRWIGSDLNNFGAAPQQKKLQAELSDLSAMEDALDELIKDCAQQLLELTDDKENERLAYVTYQDIHGIQAFHEQIVIAVKAPEETRLDVPAPREDSITVHIRSTKGPIDVYLCEVEQNHSNGKTNDGIGASPSKSSHPQCPEKEDEPPQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RTARRQPSLLVDPAQ HCCCCCCCCCCCHHH	26.46	27180971
67	Phosphorylation	KRPRFDVSLVYLTRK CCCCCCEEEHHHHHH	17.60	17203969
247	Phosphorylation	QNHSNGKTNDGIGAS ECCCCCCCCCCCCCC	39.68	28066266
254	Phosphorylation	TNDGIGASPSKSSHP CCCCCCCCCCCCCCC	25.21	26745281
256	Phosphorylation	DGIGASPSKSSHPQC CCCCCCCCCCCCCCC	42.55	28066266

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of E2F6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of E2F6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of E2F6_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of E2F6_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Protein phosphorylation and expression profiling by Yin-yangmultidimensional liquid chromatography (Yin-yang MDLC) massspectrometry.";
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.;
J. Proteome Res. 6:250-262(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67, AND MASSSPECTROMETRY.
PubMed: 17203969