| UniProt ID | WDR5_MOUSE | |
|---|---|---|
| UniProt AC | P61965 | |
| Protein Name | WD repeat-containing protein 5 | |
| Gene Name | Wdr5 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 334 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (By similarity).. | |
| Protein Sequence | MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MATEEKKPE ------CCCCCCCCH | 24.58 | - | |
| 6 | Acetylation | --MATEEKKPETEAA --CCCCCCCCHHHHH | 68.35 | 23806337 | |
| 7 | Acetylation | -MATEEKKPETEAAR -CCCCCCCCHHHHHH | 51.90 | 23806337 | |
| 27 | Ubiquitination | SSSATQSKPTPVKPN CCCCCCCCCCCCCCC | 42.99 | - | |
| 40 | Phosphorylation | PNYALKFTLAGHTKA CCEEEEEEECCCCEE | 17.70 | 25777480 | |
| 45 | Phosphorylation | KFTLAGHTKAVSSVK EEEECCCCEEEEEEE | 21.56 | 25777480 | |
| 49 | Phosphorylation | AGHTKAVSSVKFSPN CCCCEEEEEEEECCC | 33.98 | 25777480 | |
| 50 | Phosphorylation | GHTKAVSSVKFSPNG CCCEEEEEEEECCCC | 23.80 | 25777480 | |
| 54 | Phosphorylation | AVSSVKFSPNGEWLA EEEEEEECCCCCEEC | 16.25 | 25777480 | |
| 62 | Phosphorylation | PNGEWLASSSADKLI CCCCEECCCCHHHHH | 23.74 | 25777480 | |
| 63 | Phosphorylation | NGEWLASSSADKLIK CCCEECCCCHHHHHH | 24.76 | 25777480 | |
| 64 | Phosphorylation | GEWLASSSADKLIKI CCEECCCCHHHHHHH | 37.68 | 25777480 | |
| 112 | Acetylation | ASDDKTLKIWDVSSG CCCCCCEEEEECCCC | 47.16 | - | |
| 120 | Ubiquitination | IWDVSSGKCLKTLKG EEECCCCCEEEEECC | 38.04 | - | |
| 159 | Ubiquitination | SVRIWDVKTGKCLKT CEEEEECCCCCEECC | 49.43 | - | |
| 227 | Ubiquitination | VKFSPNGKYILAATL EEECCCCCEEEEEEC | 35.44 | - | |
| 250 | Malonylation | YSKGKCLKTYTGHKN CCCCCEEEEECCCCC | 49.29 | 26320211 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of WDR5_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WDR5_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WDR5_MOUSE !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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