MBIP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MBIP1_MOUSE
• UniProt AC: Q99LQ1
• Protein Name: MAP3K12-binding inhibitory protein 1
• Gene Name: Mbip
• Organism: Mus musculus (Mouse).
• Sequence Length: 341
• Subcellular Localization: Nucleus. Cytoplasm. Shows a cytoplasmic localization when co-expressed with MAP3K12..
• Protein Description: Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4..
• Protein Sequence: MAAAAELSSSSGSERSLEQCSSPLLTREVLCEVFRSLHTLTRQLNLRDDVVKITIDWNRLQSLSASQPALLLTALEQHVLYLQPFLAKLQSLMKENSTATEIRQTEAETKSELRAIHPTEDLQDEGKPKDCDVGDVKKTQNLFDPEVVQIKAGKAEIDRRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAVFTPYPGFKSHVKVSRVVNTYGPQTRPEGIAGSGHKPTGMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIKKLEDKILELEGISPEYFQSVNFSGKRRKVQPPQQNYSLAELDEKISALKRALLRKSREADSMAAHLP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MAAAAELSSSSGSER CCCHHHHHCCCCCHH	21.49	28066266
9	Phosphorylation	AAAAELSSSSGSERS CCHHHHHCCCCCHHH	40.94	28066266
10	Phosphorylation	AAAELSSSSGSERSL CHHHHHCCCCCHHHH	35.03	28066266
11	Phosphorylation	AAELSSSSGSERSLE HHHHHCCCCCHHHHH	48.57	28066266
13	Phosphorylation	ELSSSSGSERSLEQC HHHCCCCCHHHHHHH	31.61	28066266
16	Phosphorylation	SSSGSERSLEQCSSP CCCCCHHHHHHHCCC	32.01	25777480
21	Phosphorylation	ERSLEQCSSPLLTRE HHHHHHHCCCHHHHH	34.38	26824392
22	Phosphorylation	RSLEQCSSPLLTREV HHHHHHCCCHHHHHH	27.48	27087446
26	Phosphorylation	QCSSPLLTREVLCEV HHCCCHHHHHHHHHH	32.25	29472430
91	Phosphorylation	PFLAKLQSLMKENST HHHHHHHHHHHHCCC	40.65	-
297	Phosphorylation	YFQSVNFSGKRRKVQ HHHHCCCCCCCCCCC	37.90	26643407
299	Acetylation	QSVNFSGKRRKVQPP HHCCCCCCCCCCCCC	48.08	23806337
299	Ubiquitination	QSVNFSGKRRKVQPP HHCCCCCCCCCCCCC	48.08	-
330	Phosphorylation	KRALLRKSREADSMA HHHHHHHHHHHHHHH	28.99	25338131

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MBIP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MBIP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MBIP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSR2B_MOUSE	Csrp2bp	physical	19103755
KAT2A_MOUSE	Kat2a	physical	19103755
WDR5_MOUSE	Wdr5	physical	19103755

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.