KAT2A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KAT2A_MOUSE
• UniProt AC: Q9JHD2
• Protein Name: Histone acetyltransferase KAT2A {ECO:0000305}
• Gene Name: Kat2a {ECO:0000312|MGI:MGI:1343101}
• Organism: Mus musculus (Mouse).
• Sequence Length: 830
• Subcellular Localization: Nucleus . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation.
• Protein Description: Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context. [PubMed: 28424240 Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (By similarity Succinylation of histones gives a specific tag for epigenetic transcription activation (By similarity Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (By similarity In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (By similarity Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (By similarity Acetylation of histones gives a specific tag for epigenetic transcription activation]
• Protein Sequence: MAEPSQAPNPVPAAQPRPLHSPAPAPTSTPAPSPASASTPAPTPAPAPAPAAAPAGSTGSGGAGVGSGGDPARPGLSQQQRASQRKAQVRGLPRAKKLEKLGVFSACKANETCKCNGWKNPKPPTAPRMDLQQPAANLSELCRSCEHPLADHVSHLENVSEDEINRLLGMVVDVENLFMSVHKEEDTDTKQVYFYLFKLLRKCILQMTRPVVEGSLGSPPFEKPNIEQGVLNFVQYKFSHLAPRERQTMFELSKMFLLCLNYWKLETPAQFRQRSQSEDVATYKVNYTRWLCYCHVPQSCDSLPRYETTHVFGRSLLRSIFTVTRRQLLEKFRVEKDKLVPEKRTLILTHFPKFLSMLEEEIYGANSPIWESGFTMPPSEGTQLVPRPATVSATVVPSFSPSMGGGSNSSLSLDSAGTEPMPAGEKRKLPENLTLEDAKRLRVMGDIPMELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWLVGLQNVFSHQLPRMPKEYIARLVFDPKHKTLALIKDGRVIGGICFRMFPTQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIKVPKSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEGVRQIPVESVPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKSHPSAWPFMEPVKKSEAPDYYEVIRFPIDLKTMTERLRSRYYVTRKLFVADLQRVIANCREYNPPDSEYCRCASALEKFFYFKLKEGGLIDK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAEPSQAPN ------CCCCCCCCC	37.09	-
21	Phosphorylation	AQPRPLHSPAPAPTS CCCCCCCCCCCCCCC	30.36	25338131
27	Phosphorylation	HSPAPAPTSTPAPSP CCCCCCCCCCCCCCC	47.54	25338131
77	Phosphorylation	DPARPGLSQQQRASQ CCCCCCCCHHHHHHH	31.68	29895711
277	Phosphorylation	QFRQRSQSEDVATYK HHHHHHCCCCCEECE	36.69	26824392
315	Phosphorylation	TTHVFGRSLLRSIFT CHHHHHHHHHHHHHH	31.94	28059163
324	Phosphorylation	LRSIFTVTRRQLLEK HHHHHHHHHHHHHHH	19.65	28059163
434	Phosphorylation	RKLPENLTLEDAKRL CCCCCCCCHHHHHHH	39.42	20139300
714	Acetylation	TGWKPLGKEKGKELK CCCCCCCHHCCCCCC	65.03	7304087
727	Phosphorylation	LKDPDQLYTTLKNLL CCCHHHHHHHHHHHH	7.64	-
729	Phosphorylation	DPDQLYTTLKNLLAQ CHHHHHHHHHHHHHH	23.37	-
753	Phosphorylation	FMEPVKKSEAPDYYE CCCCCCCCCCCCCHH	33.02	30635358

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KAT2A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KAT2A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KAT2A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOTC1_MOUSE	Notch1	physical	10747963
H4_BOVIN	H4	physical	9742083
CSR2B_MOUSE	Csrp2bp	physical	19103755
MBIP1_MOUSE	Mbip	physical	19103755
WDR5_MOUSE	Wdr5	physical	19103755
H31_HUMAN	HIST1H3A	physical	9742083

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.