CSR2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CSR2B_MOUSE
• UniProt AC: Q8CID0
• Protein Name: Cysteine-rich protein 2-binding protein
• Gene Name: Kat14 {ECO:0000250|UniProtKB:Q9H8E8}
• Organism: Mus musculus (Mouse).
• Sequence Length: 779
• Subcellular Localization: Nucleus. Cytoplasm. Mainly nuclear..
• Protein Description: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. May function as a scaffold for the ATAC complex to promote ATAC complex stability. Has also weak histone acetyltransferase activity toward histone H4. Required for the normal progression through G1 and G2/M phases of the cell cycle (By similarity)..
• Protein Sequence: MDSSIHLSGLLSRHDDDATRTSTSEGLEEGEVEGETLLIVESEDQASVDLSHDQSGDSLNSDEGDVSWMEEQLSYFCDKCQKWIPASQLREQLSYLKGDNFFRFTCCDCSADGKEQYERLKLTWQQVVMLAMYNLSLEGSGRQGYFRWKEDICAFIEKHWTFLLGNRKKTSTWWSTVAGCLSVGSPVYFRSGAQEFGEPGWWKLVHNRPPTMRPEGEKLAASTLKVKASKPTLDPIITVEGLRKRASRNPVESAMELKEKRSRTQEAKDIRRAQKEAAGLLDRSTSSTPVKFISRGRRPDLILEKGEVIDFSSLSSSDRTPLTSPSPSPSLDFSAPGTPASHSATPSLLSEADLIPDVMPPQALFHDDDELEGDGVIDPGMEYIPPPAGSASGLLGSRKKVRAPEQIKQEVDSEEEKPDRMDGDSEDTDSNISLHTRAREKRKPPLEKDMKPKGPRYTPVSIYEEKLLLKRLEACPGAVAMTPEARRLKRKLIVRQAKRDRGLPLFDLDEVVNAALLLVDGIYGAKDGGASRLAAGQATYRTTCQDFRILDRYQTALPARKGFRHQTTRFLYRLVGSEDLAVDQSIISPYTSRILKPYIRRDYETKPPKLQLLSQIRSHLHRSDPHWTPGPDAPLDYCYVRPNHIPTINSMCQEFFWPGIDLSECLQYPDFSVVVLYKKVIVAFGFMVPDVKYNEAYISFLLVHPEWRRAGIATFMIYHLIQTCMGKDVTLHVSASNPAMLLYQKFGFKTEEYVLDFYDKYYPLESTECKHAFFLRLRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MDSSIHLSGL -----CCCCEEHHHH	29.87	25338131
4	Phosphorylation	----MDSSIHLSGLL ----CCCCEEHHHHH	15.12	-
211	Phosphorylation	LVHNRPPTMRPEGEK HHCCCCCCCCCCCHH	28.61	21454597
230	Acetylation	TLKVKASKPTLDPII EEEECCCCCCCCCEE	47.05	23806337
232	Phosphorylation	KVKASKPTLDPIITV EECCCCCCCCCEEEH	47.75	28576409
238	Phosphorylation	PTLDPIITVEGLRKR CCCCCEEEHHHHHHH	17.14	28576409
275	Acetylation	KDIRRAQKEAAGLLD HHHHHHHHHHHHCCC	48.62	23806337
284	Phosphorylation	AAGLLDRSTSSTPVK HHHCCCCCCCCCCEE	32.10	29514104
286	Phosphorylation	GLLDRSTSSTPVKFI HCCCCCCCCCCEEEH	33.20	29514104
287	Phosphorylation	LLDRSTSSTPVKFIS CCCCCCCCCCEEEHH	36.50	26643407
288	Phosphorylation	LDRSTSSTPVKFISR CCCCCCCCCEEEHHC	31.69	27600695
291	Acetylation	STSSTPVKFISRGRR CCCCCCEEEHHCCCC	37.88	23806337
413	Phosphorylation	QIKQEVDSEEEKPDR HHHHHCCCCCCCCCC	52.67	26824392
425	Phosphorylation	PDRMDGDSEDTDSNI CCCCCCCCCCCCCCC	42.79	21149613
428	Phosphorylation	MDGDSEDTDSNISLH CCCCCCCCCCCCHHH	36.96	21149613
430	Phosphorylation	GDSEDTDSNISLHTR CCCCCCCCCCHHHHH	37.85	28066266
433	Phosphorylation	EDTDSNISLHTRARE CCCCCCCHHHHHHHH	20.53	28066266
436	Phosphorylation	DSNISLHTRAREKRK CCCCHHHHHHHHHCC	31.17	21149613

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CSR2B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CSR2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CSR2B_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CSR2B_MOUSE	Csrp2bp	physical	19103755
KAT2A_MOUSE	Kat2a	physical	19103755
TADA3_MOUSE	Tada3	physical	19103755
ZZZ3_MOUSE	Zzz3	physical	19103755
MBIP1_MOUSE	Mbip	physical	19103755
WDR5_MOUSE	Wdr5	physical	19103755
YETS2_MOUSE	Yeats2	physical	19103755
SGF29_MOUSE	Ccdc101	physical	19103755
NC2B_MOUSE	Dr1	physical	19103755

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.