NC2B_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NC2B_MOUSE
• UniProt AC: Q91WV0
• Protein Name: Protein Dr1
• Gene Name: Dr1
• Organism: Mus musculus (Mouse).
• Sequence Length: 176
• Subcellular Localization: Nucleus.
• Protein Description: The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)..
• Protein Sequence: MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASTQAGSSQDEEDDDDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASSSGNDD ------CCCCCCCCC	20.37	-
3	Phosphorylation	-----MASSSGNDDD -----CCCCCCCCCC	24.60	29472430
4	Phosphorylation	----MASSSGNDDDL ----CCCCCCCCCCC	32.50	29472430
5	Phosphorylation	---MASSSGNDDDLT ---CCCCCCCCCCCC	38.84	29472430
12	Phosphorylation	SGNDDDLTIPRAAIN CCCCCCCCCCHHHHH	35.61	30635358
25	Phosphorylation	INKMIKETLPNVRVA HHHHHHHHCCCCEEC	42.38	18779572
105	Phosphorylation	ALKRRKASSRLENLG HHHHHHHHHHHHHCC	21.01	25521595
106	Phosphorylation	LKRRKASSRLENLGI HHHHHHHHHHHHCCC	45.83	26824392
128	Ubiquitination	QQQELFAKARQQQAE HHHHHHHHHHHHHHH	36.45	27667366
166	Phosphorylation	SASTQAGSSQDEEDD CHHCCCCCCCCCCCC	28.04	29899451
167	Phosphorylation	ASTQAGSSQDEEDDD HHCCCCCCCCCCCCC	40.51	29899451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NC2B_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NC2B_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NC2B_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of NC2B_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.