TADA3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TADA3_MOUSE
• UniProt AC: Q8R0L9
• Protein Name: Transcriptional adapter 3
• Gene Name: Tada3
• Organism: Mus musculus (Mouse).
• Sequence Length: 432
• Subcellular Localization: Nucleus.
• Protein Description: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactivator for p53/TP53-dependent transcriptional activation (By similarity). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity)..
• Protein Sequence: MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRRLRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKTGHGPGPGPGRPKSKNVQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPPEDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLIGPLTELDTKDVDALLKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPRNQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHNRTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTLKERESILKLLDG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Acetylation	KKQKLEGKTGHGPGP CCCCCCCCCCCCCCC	41.79	23806337
110	Phosphorylation	KQKLEGKTGHGPGPG CCCCCCCCCCCCCCC	45.31	-
123	Phosphorylation	PGPGRPKSKNVQPKI CCCCCCCCCCCCCCC	31.95	22802335
280	Phosphorylation	IISPMEDSPIPDMSG CCCCCCCCCCCCCCC	16.06	29514104
290	Phosphorylation	PDMSGKESGADGAST CCCCCCCCCCCCCCC	42.65	29899451
296	Phosphorylation	ESGADGASTSPRNQN CCCCCCCCCCCCCCC	34.64	24899341
297	Phosphorylation	SGADGASTSPRNQNK CCCCCCCCCCCCCCC	42.06	25521595
298	Phosphorylation	GADGASTSPRNQNKP CCCCCCCCCCCCCCC	21.26	27087446
338	Phosphorylation	EDRPAEDSEDEVLAE CCCCCCCCHHHHHHH	38.15	21659605
404	Acetylation	KIMAARQKKRTPTKK HHHHHHHHCCCCCHH	38.37	7289883
410	Acetylation	QKKRTPTKKEKDQAW HHCCCCCHHHHHHHH	61.20	7289893
418	Acetylation	KEKDQAWKTLKERES HHHHHHHHHHHHHHH	47.17	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TADA3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TADA3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TADA3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ESR1_HUMAN	ESR1	physical	12034840

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.