YETS2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: YETS2_MOUSE
• UniProt AC: Q3TUF7
• Protein Name: YEATS domain-containing protein 2 {ECO:0000305}
• Gene Name: Yeats2 {ECO:0000312|MGI:MGI:2447762}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1407
• Subcellular Localization: Nucleus .
• Protein Description: Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors..
• Protein Sequence: MSGIKRTIKETDPDYEDVSVALPNKRHKAIESSARDAAVQKIETIIKEQFALEMKNKEHEIDVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGLKTFDPMAFNHPAIKKFLESPSRSSSPTNQRSETPSANHSESDSLSQHNDFLSDKDNNSNVDVEERPPSTGEQRPSRKAGRDTSSISGSHKRELRNADLTGDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDSVYPQSSESDVCDAPPPTLTLPAAVKASAVAQSPEPAAAAPVGEGFPETTEAERHSTFYSLPSSLERTPTKVTTAQKVTFSSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHLKQGTASSGVSNPHVIVDKPGQVIGASTPSTGSPTSKLPVASQASQGTGSPIPKIHGSSFLTSTVKQEESLFASMPPLCPIGSHPKVQSPKAVTGGLGAFTKVIIKQEPGEAPHVSTTGAASQSAFPQYVTVKGGHMIAVSPQKQVISAGEGTTQSPKIAPSKVVGVPVGSALPSTVKQAVAISSGQILVAKASSSVTKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKTQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAAAGGSGSSGAGGGSGGGGGSGAGGTPSTSGPGGGPQHLTYTSYILKQTPQGTFLVGQPSPQTPGKQLTTASVVQGTLGVSSSSAQGQQTLKVISGQKTTLFTQAATAGQASLLKLPDNTLKSVPAAPQLAKPGTTMLRVAGGVITAAPSPAVAFSANGAVHQSEGSTPVSSSVGSIIKTPGQPQVCVSQATMATCKGPAAVAGTAASLVSAPSSISGKATVSGLLKVHSAQSSPQQAVLTIPSQLKPLSINTSGGVQTVLMPVNKVVQSFSTSKLPTTVLPISVPNQAAPSSAPVAIAKVKTEPETPGPNCISQENQVAVKTEESSELSNYVIKVDHLETIQQLLTAVVKKIPLITAKGDDASCFSAKSLEQYYGWNIGKRRAAEWQRAMTVRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRHDGDSIEDVLTQIDSEPECLSSFSTADDLCRKLEDLQQFQKREPENEEEVDILSLSEPLKTNIKKEQEEKQEEMRFYLPPTPGSGFVGDITQKIGITLQPVALHRNMYASVVEDMILKATEQLVSDILRQALAVGYQTASPNRIPKEITVSNIHQAICNIPFLDFLTNKHMGRLNEDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGIKRTIK ------CCCCCCCCC	61.60	25619855
41	Acetylation	ARDAAVQKIETIIKE HHHHHHHHHHHHHHH	35.59	22826441
57	Acetylation	FALEMKNKEHEIDVI HHHHCCCCCCCCCHH	55.73	134223
100	Acetylation	LKVSEGLKTFDPMAF EEHHCCCCCCCCHHH	58.99	22826441
118	Phosphorylation	AIKKFLESPSRSSSP HHHHHHHCCCCCCCC	30.26	26824392
120	Phosphorylation	KKFLESPSRSSSPTN HHHHHCCCCCCCCCC	54.82	21082442
122	Phosphorylation	FLESPSRSSSPTNQR HHHCCCCCCCCCCCC	39.23	22345495
123	Phosphorylation	LESPSRSSSPTNQRS HHCCCCCCCCCCCCC	38.95	22345495
124	Phosphorylation	ESPSRSSSPTNQRSE HCCCCCCCCCCCCCC	36.67	25266776
126	Phosphorylation	PSRSSSPTNQRSETP CCCCCCCCCCCCCCC	46.03	22345495
130	Phosphorylation	SSPTNQRSETPSANH CCCCCCCCCCCCCCC	35.74	26643407
132	Phosphorylation	PTNQRSETPSANHSE CCCCCCCCCCCCCCC	24.64	26643407
134	Phosphorylation	NQRSETPSANHSESD CCCCCCCCCCCCCCC	49.47	26643407
138	Phosphorylation	ETPSANHSESDSLSQ CCCCCCCCCCCCHHH	38.31	26643407
140	Phosphorylation	PSANHSESDSLSQHN CCCCCCCCCCHHHHH	35.20	26643407
142	Phosphorylation	ANHSESDSLSQHNDF CCCCCCCCHHHHHHH	38.92	25338131
144	Phosphorylation	HSESDSLSQHNDFLS CCCCCCHHHHHHHCC	33.09	25338131
151	Phosphorylation	SQHNDFLSDKDNNSN HHHHHHCCCCCCCCC	42.48	25338131
157	Phosphorylation	LSDKDNNSNVDVEER CCCCCCCCCCCCHHC	44.47	23375375
167	Phosphorylation	DVEERPPSTGEQRPS CCHHCCCCCCCCCCC	52.29	28285833
168	Phosphorylation	VEERPPSTGEQRPSR CHHCCCCCCCCCCCC	50.98	27717184
174	Phosphorylation	STGEQRPSRKAGRDT CCCCCCCCCCCCCCC	48.91	27717184
182	Phosphorylation	RKAGRDTSSISGSHK CCCCCCCCCCCCCCC	29.93	28576409
185	Phosphorylation	GRDTSSISGSHKREL CCCCCCCCCCCCHHH	35.87	29899451
187	Phosphorylation	DTSSISGSHKRELRN CCCCCCCCCCHHHHC	21.03	29899451
189	Acetylation	SSISGSHKRELRNAD CCCCCCCCHHHHCCC	49.63	23806337
210	Phosphorylation	SRLFVKKTIVVGNVS HCEEEEEEEEECCHH	17.18	21454597
217	Phosphorylation	TIVVGNVSKYIPPDK EEEECCHHHCCCCCC	24.60	21454597
366	Phosphorylation	LPAAVKASAVAQSPE CCHHHHHHHHHCCCC	19.98	25619855
371	Phosphorylation	KASAVAQSPEPAAAA HHHHHHCCCCCCCCC	22.84	27087446
387	Phosphorylation	VGEGFPETTEAERHS CCCCCCCCCHHHCCC	30.12	25619855
388	Phosphorylation	GEGFPETTEAERHST CCCCCCCCHHHCCCC	31.38	25619855
394	Phosphorylation	TTEAERHSTFYSLPS CCHHHCCCCCCCCCC	26.83	25777480
395	Phosphorylation	TEAERHSTFYSLPSS CHHHCCCCCCCCCCC	22.07	25777480
397	Phosphorylation	AERHSTFYSLPSSLE HHCCCCCCCCCCCCC	14.91	25777480
398	Phosphorylation	ERHSTFYSLPSSLER HCCCCCCCCCCCCCC	29.61	26643407
401	Phosphorylation	STFYSLPSSLERTPT CCCCCCCCCCCCCCC	53.50	25777480
402	Phosphorylation	TFYSLPSSLERTPTK CCCCCCCCCCCCCCC	32.10	26643407
406	Phosphorylation	LPSSLERTPTKVTTA CCCCCCCCCCCCEEE	26.40	25266776
408	Phosphorylation	SSLERTPTKVTTAQK CCCCCCCCCCEEEEE	37.22	25266776
409	Acetylation	SLERTPTKVTTAQKV CCCCCCCCCEEEEEE	38.49	22826441
415	Acetylation	TKVTTAQKVTFSSHG CCCEEEEEEEECCCC	40.55	22826441
439	Phosphorylation	SCKIVPQSQVPNPES CCEEECHHHCCCCCC	27.37	28285833
446	Phosphorylation	SQVPNPESPGKSFQP HHCCCCCCCCCCCCC	39.96	27087446
449	Acetylation	PNPESPGKSFQPITM CCCCCCCCCCCCEEE	52.02	23806337
450	Phosphorylation	NPESPGKSFQPITMS CCCCCCCCCCCEEEE	34.72	24453211
457	Phosphorylation	SFQPITMSCKIVSGS CCCCEEEEEEEEECC	12.01	24759943
459	Acetylation	QPITMSCKIVSGSPI CCEEEEEEEEECCCC	38.54	22826441
462	Phosphorylation	TMSCKIVSGSPISTP EEEEEEEECCCCCCC	36.71	21082442
464	Phosphorylation	SCKIVSGSPISTPSP EEEEEECCCCCCCCC	16.14	26824392
467	Phosphorylation	IVSGSPISTPSPSPL EEECCCCCCCCCCCC	37.34	26643407
468	Phosphorylation	VSGSPISTPSPSPLP EECCCCCCCCCCCCC	28.62	21082442
470	Phosphorylation	GSPISTPSPSPLPRT CCCCCCCCCCCCCCC	37.79	26745281
472	Phosphorylation	PISTPSPSPLPRTPT CCCCCCCCCCCCCCC	43.32	26824392
477	Phosphorylation	SPSPLPRTPTSTPVH CCCCCCCCCCCCCEE	29.04	25266776
479	Phosphorylation	SPLPRTPTSTPVHLK CCCCCCCCCCCEEEC	44.62	26643407
480	Phosphorylation	PLPRTPTSTPVHLKQ CCCCCCCCCCEEECC	31.73	26643407
481	Phosphorylation	LPRTPTSTPVHLKQG CCCCCCCCCEEECCC	31.63	26643407
489	Phosphorylation	PVHLKQGTASSGVSN CEEECCCCCCCCCCC	22.37	25777480
491	Phosphorylation	HLKQGTASSGVSNPH EECCCCCCCCCCCCE	27.71	25777480
492	Phosphorylation	LKQGTASSGVSNPHV ECCCCCCCCCCCCEE	40.53	25777480
495	Phosphorylation	GTASSGVSNPHVIVD CCCCCCCCCCEEEEC	48.44	25777480
511	Phosphorylation	PGQVIGASTPSTGSP CCCEEECCCCCCCCC	35.32	25777480
512	Phosphorylation	GQVIGASTPSTGSPT CCEEECCCCCCCCCC	22.26	25777480
514	Phosphorylation	VIGASTPSTGSPTSK EEECCCCCCCCCCCC	45.55	26643407
515	Phosphorylation	IGASTPSTGSPTSKL EECCCCCCCCCCCCC	42.77	25777480
517	Phosphorylation	ASTPSTGSPTSKLPV CCCCCCCCCCCCCCC	25.70	26643407
519	Phosphorylation	TPSTGSPTSKLPVAS CCCCCCCCCCCCCCC	39.94	26643407
520	Phosphorylation	PSTGSPTSKLPVASQ CCCCCCCCCCCCCCC	35.26	25777480
526	Phosphorylation	TSKLPVASQASQGTG CCCCCCCCCCCCCCC	26.89	25619855
529	Phosphorylation	LPVASQASQGTGSPI CCCCCCCCCCCCCCC	22.85	25619855
532	Phosphorylation	ASQASQGTGSPIPKI CCCCCCCCCCCCCCC	27.18	25619855
534	Phosphorylation	QASQGTGSPIPKIHG CCCCCCCCCCCCCCC	21.35	27087446
542	Phosphorylation	PIPKIHGSSFLTSTV CCCCCCCCCCCCCCC	12.07	21454597
548	Phosphorylation	GSSFLTSTVKQEESL CCCCCCCCCCHHHHH	26.87	21454597
573	Phosphorylation	GSHPKVQSPKAVTGG CCCCCCCCCCCCCCC	31.21	24759943
600	O-linked_Glycosylation	PGEAPHVSTTGAASQ CCCCCCCCCCCCCCC	19.74	51588547
601	O-linked_Glycosylation	GEAPHVSTTGAASQS CCCCCCCCCCCCCCC	28.32	21606357
602	O-linked_Glycosylation	EAPHVSTTGAASQSA CCCCCCCCCCCCCCC	19.81	51588555
625	Phosphorylation	GGHMIAVSPQKQVIS CCEEEEECCCCCEEE	16.76	26824392
637	Phosphorylation	VISAGEGTTQSPKIA EEECCCCCCCCCCCC	19.84	28066266
638	Phosphorylation	ISAGEGTTQSPKIAP EECCCCCCCCCCCCH	37.60	28066266
640	Phosphorylation	AGEGTTQSPKIAPSK CCCCCCCCCCCCHHH	26.52	22006019
769	Acetylation	NSKNPSGKGKLLLIP CCCCCCCCCEEEEEC	58.15	22826441
771	Acetylation	KNPSGKGKLLLIPQG CCCCCCCEEEEECCC	39.17	22826441
853	Phosphorylation	TFLVGQPSPQTPGKQ EEECCCCCCCCCCCC	23.04	26643407
856	Phosphorylation	VGQPSPQTPGKQLTT CCCCCCCCCCCCCCC	37.08	26643407
928	Phosphorylation	PQLAKPGTTMLRVAG HHHCCCCCEEEEEEC	19.98	28542873
929	Phosphorylation	QLAKPGTTMLRVAGG HHCCCCCEEEEEECC	21.81	28542873
1026	Phosphorylation	LKVHSAQSSPQQAVL EEEEECCCCCCEEEE	43.64	25338131
1100	Phosphorylation	KVKTEPETPGPNCIS EEECCCCCCCCCCCC	44.24	29514104
1204	Phosphorylation	NPRFHHLTPLKTKHI CCCCCCCCCCCCHHH	23.40	27600695
1244	Phosphorylation	DVLTQIDSEPECLSS HHHHHCCCCHHHHHC	57.59	-
1365	Phosphorylation	RQALAVGYQTASPNR HHHHHHCCCCCCCCC	8.97	24759943
1367	Phosphorylation	ALAVGYQTASPNRIP HHHHCCCCCCCCCCC	22.18	26745281
1369	Phosphorylation	AVGYQTASPNRIPKE HHCCCCCCCCCCCCE	26.54	26824392
1396	Phosphorylation	IPFLDFLTNKHMGRL CCHHHHHCHHCCCCC	42.06	28059163

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of YETS2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of YETS2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of YETS2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of YETS2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.