PHF20_MOUSE - dbPTM
PHF20_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PHF20_MOUSE
UniProt AC Q8BLG0
Protein Name PHD finger protein 20
Gene Name Phf20
Organism Mus musculus (Mouse).
Sequence Length 1010
Subcellular Localization Nucleus .
Protein Description Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage (By similarity). Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues..
Protein Sequence MTKHPPNRRGISFEVGAQLEARDRLKNWYPAHIEDIDYEEGRVLIHFKRWNHRYDEWFCWDSPYLRPLEKIQLRKEGLHDEDGSSEFQINQQVLACWSDCRFYPARVTAVNKDGTYTVKFYDGVVQTVKHIHVKAFSKDQNIVGNARPKETDHKSLSSSPEKREKFKEQRKVTVNVKKDKVEKALKTEKRPKQPDKEGKLICSEKGKVSEKSLPKNEKEDKENISENEREYSGDAQVEKKPEKDLVKNPQENLKEPKRKRGRPPSITPTAVDSNSQTLQPITLELRRRKISKRSDTPLKRPRLDKNSPQEQSKKRSENSDKDLSRRRSSRLSTNGTREILDPDSIVPDLVHTVDTNPLPDKSPSAKDSAEGQLKSPLEAGQVSSALTCHPIGDGLGAADLELNCKSMGENTMKTEPVSPLAEVQEVSTVEVPNTLKKVDDSVTLNVPAVDLDHKFRCKVLDCLKFFRKAKLLHYHMKYFHGMEKSPEPEEGPGKTHVQTRGSAVPDKTSQESLTRKRVSASSPTAKEKEKTKEKKFKELVRVKPKKKKKKKKKTKPECPCSEDISDTSQEPSPPKTFAVTRCGSSHKPGVHMSPQLHGSDNGNHKGKLKTCEEDNLSESSSESFLWSDEEYGQDVDVTTNPDEELEGDDRYDFEVVRCICEVQEENDFMIQCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLDQNYSHQNARKIVATHQLLGDVQRVIQVLHGLQLKMSILQSREHPDLQLWCQPWKQHSGEGRAHPRHIHITDARSEESPSYRTLNGAVEKPSPLPRSVEESYITSEHCYQKPRAYYPAVEQRLVVETRGSALDAAVSPLCENGDDSLSPRLGWPIDQDRSRGDIDPKPSSPKVREYISKNVLPEETPARKLLDRGGEGLVSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLPQLKHCIKQLLTDLGKVQQIALCCST
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
48MethylationGRVLIHFKRWNHRYD
CEEEEEEEECCCCCC		42.20-
155PhosphorylationPKETDHKSLSSSPEK
CCCCCCCCCCCCHHH		30.0223737553
157PhosphorylationETDHKSLSSSPEKRE
CCCCCCCCCCHHHHH		35.5428066266
158PhosphorylationTDHKSLSSSPEKREK
CCCCCCCCCHHHHHH		56.0325159016
159PhosphorylationDHKSLSSSPEKREKF
CCCCCCCCHHHHHHH		33.4325159016
225PhosphorylationKEDKENISENEREYS
HHHHCCCCHHHHHHC		46.0525159016
277PhosphorylationAVDSNSQTLQPITLE
EECCCCCEECEEEHH		27.47-
291PhosphorylationELRRRKISKRSDTPL
HHHHHHHHCCCCCCC		25.6728059163
307PhosphorylationRPRLDKNSPQEQSKK
CCCCCCCCHHHHHHH		33.4322668510
332PhosphorylationRRRSSRLSTNGTREI
HHHHHCCCCCCCCCC		20.7929514104
344PhosphorylationREILDPDSIVPDLVH
CCCCCHHHCCCCCEE		30.7626643407
352PhosphorylationIVPDLVHTVDTNPLP
CCCCCEEECCCCCCC		16.7625293948
355PhosphorylationDLVHTVDTNPLPDKS
CCEEECCCCCCCCCC		34.1126745281
362PhosphorylationTNPLPDKSPSAKDSA
CCCCCCCCCCHHHCC		31.3125266776
364PhosphorylationPLPDKSPSAKDSAEG
CCCCCCCCHHHCCCC		55.8525293948
406PhosphorylationDLELNCKSMGENTMK
HHEECCCCCCCCCCC		33.9326745281
411PhosphorylationCKSMGENTMKTEPVS
CCCCCCCCCCCCCCC		18.7526745281
414PhosphorylationMGENTMKTEPVSPLA
CCCCCCCCCCCCCCC		34.4026643407
418PhosphorylationTMKTEPVSPLAEVQE
CCCCCCCCCCCEEEE		25.5522942356
478PhosphorylationLLHYHMKYFHGMEKS
HHHHHHHHHCCCCCC		8.0125159016
485PhosphorylationYFHGMEKSPEPEEGP
HHCCCCCCCCCCCCC		22.6126824392
508PhosphorylationGSAVPDKTSQESLTR
CCCCCCCCCHHHHHH		42.92-
509PhosphorylationSAVPDKTSQESLTRK
CCCCCCCCHHHHHHH		37.38-
519PhosphorylationSLTRKRVSASSPTAK
HHHHHHHCCCCCCHH		26.8525338131
521PhosphorylationTRKRVSASSPTAKEK
HHHHHCCCCCCHHHH		29.3725266776
522PhosphorylationRKRVSASSPTAKEKE
HHHHCCCCCCHHHHH		26.4524453211
524PhosphorylationRVSASSPTAKEKEKT
HHCCCCCCHHHHHHH		52.9228066266
561PhosphorylationTKPECPCSEDISDTS
CCCCCCCCCCCCCCC		24.3621149613
565PhosphorylationCPCSEDISDTSQEPS
CCCCCCCCCCCCCCC		47.3521149613
567PhosphorylationCSEDISDTSQEPSPP
CCCCCCCCCCCCCCC		26.0621149613
568PhosphorylationSEDISDTSQEPSPPK
CCCCCCCCCCCCCCC		37.2221149613
572PhosphorylationSDTSQEPSPPKTFAV
CCCCCCCCCCCEEEE		53.7521149613
599PhosphorylationMSPQLHGSDNGNHKG
CCCCCCCCCCCCCCC		19.7019854140
841AcetylationTSEHCYQKPRAYYPA
CCHHHCCCCHHCCCC		15.25-
867PhosphorylationSALDAAVSPLCENGD
CHHHHHHHHHCCCCC		13.8730635358
876PhosphorylationLCENGDDSLSPRLGW
HCCCCCCCCCCCCCC		35.1721183079
878PhosphorylationENGDDSLSPRLGWPI
CCCCCCCCCCCCCCC		16.3621183079
899PhosphorylationGDIDPKPSSPKVREY
CCCCCCCCCHHHHHH		66.4525159016
900PhosphorylationDIDPKPSSPKVREYI
CCCCCCCCHHHHHHH		36.9525159016
957PhosphorylationEVTHRMDSIEKELDV
HHHHCHHHHHHHHHH		24.2523737553
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of PHF20_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PHF20_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PHF20_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
P53_HUMANTP53physical
22864287
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PHF20_MOUSE

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Related Literatures of Post-Translational Modification

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