SYYC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SYYC_HUMAN
• UniProt AC: P54577
• Protein Name: Tyrosine--tRNA ligase, cytoplasmic
• Gene Name: YARS
• Organism: Homo sapiens (Human).
• Sequence Length: 528
• Subcellular Localization: Cytoplasm .
• Protein Description: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr)..
• Protein Sequence: MGDAPSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLPALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREKFNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKIDVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDPPAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFMTKLGSISCKSLKGGNIS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MGDAPSPE -------CCCCCCHH	11.20	19413330
2	Acetylation	------MGDAPSPEE ------CCCCCCHHH	39.52	19413330
6	Phosphorylation	--MGDAPSPEEKLHL --CCCCCCHHHHHHH	46.82	21815630
10	Ubiquitination	DAPSPEEKLHLITRN CCCCHHHHHHHHHHC	39.27	-
10	2-Hydroxyisobutyrylation	DAPSPEEKLHLITRN CCCCHHHHHHHHHHC	39.27	-
26	Ubiquitination	QEVLGEEKLKEILKE HHHHCHHHHHHHHHH	61.63	21906983
26	Acetylation	QEVLGEEKLKEILKE HHHHCHHHHHHHHHH	61.63	26822725
28	Ubiquitination	VLGEEKLKEILKERE HHCHHHHHHHHHHCC	54.50	-
32	Ubiquitination	EKLKEILKERELKIY HHHHHHHHHCCCEEE	61.46	-
39	Phosphorylation	KERELKIYWGTATTG HHCCCEEEEECCCCC	9.01	26074081
42	Phosphorylation	ELKIYWGTATTGKPH CCEEEEECCCCCCCE	13.49	26074081
44	Phosphorylation	KIYWGTATTGKPHVA EEEEECCCCCCCEEE	35.60	26074081
45	Phosphorylation	IYWGTATTGKPHVAY EEEECCCCCCCEEEE	40.52	26074081
47	Acetylation	WGTATTGKPHVAYFV EECCCCCCCEEEEEE	29.83	26051181
52	Phosphorylation	TGKPHVAYFVPMSKI CCCCEEEEEEEHHHH	12.20	26074081
57	Phosphorylation	VAYFVPMSKIADFLK EEEEEEHHHHHHHHH	18.16	26074081
70	Phosphorylation	LKAGCEVTILFADLH HHHCCEEEEEEHHHH	6.94	27251275
79	Phosphorylation	LFADLHAYLDNMKAP EEHHHHHHHHCCCCC	12.11	27251275
95	Phosphorylation	ELLELRVSYYENVIK HHHHHHHHHHHHHHH	18.63	28152594
96	Phosphorylation	LLELRVSYYENVIKA HHHHHHHHHHHHHHH	16.37	28152594
97	Phosphorylation	LELRVSYYENVIKAM HHHHHHHHHHHHHHH	8.10	28152594
104	Sulfoxidation	YENVIKAMLESIGVP HHHHHHHHHHHCCCC	3.47	21406390
107	Phosphorylation	VIKAMLESIGVPLEK HHHHHHHHCCCCHHH	22.23	19413330
114	Ubiquitination	SIGVPLEKLKFIKGT HCCCCHHHCCCCCCC	65.74	21906983
116	Ubiquitination	GVPLEKLKFIKGTDY CCCHHHCCCCCCCCC	56.99	-
119	Ubiquitination	LEKLKFIKGTDYQLS HHHCCCCCCCCCCCC	59.91	21906983
119	2-Hydroxyisobutyrylation	LEKLKFIKGTDYQLS HHHCCCCCCCCCCCC	59.91	-
126	Phosphorylation	KGTDYQLSKEYTLDV CCCCCCCCEEEEEEE	14.12	30576142
127	Ubiquitination	GTDYQLSKEYTLDVY CCCCCCCEEEEEEEE	64.43	21906983
129	Phosphorylation	DYQLSKEYTLDVYRL CCCCCEEEEEEEEEH	19.15	21406692
130	Phosphorylation	YQLSKEYTLDVYRLS CCCCEEEEEEEEEHH	19.99	21406692
134	Phosphorylation	KEYTLDVYRLSSVVT EEEEEEEEEHHHHHC	12.90	21406692
137	Phosphorylation	TLDVYRLSSVVTQHD EEEEEEHHHHHCCCC	16.46	21406692
138	Phosphorylation	LDVYRLSSVVTQHDS EEEEEHHHHHCCCCH	25.79	21406692
141	Phosphorylation	YRLSSVVTQHDSKKA EEHHHHHCCCCHHHC	20.31	21406692
145	Phosphorylation	SVVTQHDSKKAGAEV HHHCCCCHHHCCCHH	33.65	21406692
146	Acetylation	VVTQHDSKKAGAEVV HHCCCCHHHCCCHHH	53.34	23236377
146	Ubiquitination	VVTQHDSKKAGAEVV HHCCCCHHHCCCHHH	53.34	19608861
146	2-Hydroxyisobutyrylation	VVTQHDSKKAGAEVV HHCCCCHHHCCCHHH	53.34	-
146	Succinylation	VVTQHDSKKAGAEVV HHCCCCHHHCCCHHH	53.34	23954790
147	Ubiquitination	VTQHDSKKAGAEVVK HCCCCHHHCCCHHHH	56.88	21906983
154	Ubiquitination	KAGAEVVKQVEHPLL HCCCHHHHHCCCHHH	54.52	-
190	Ubiquitination	FGGIDQRKIFTFAEK CCCCCHHHHHHHHHH	36.22	-
190	Acetylation	FGGIDQRKIFTFAEK CCCCCHHHHHHHHHH	36.22	26051181
190	Malonylation	FGGIDQRKIFTFAEK CCCCCHHHHHHHHHH	36.22	26320211
197	Acetylation	KIFTFAEKYLPALGY HHHHHHHHHHHHCCC	48.97	19608861
197	Ubiquitination	KIFTFAEKYLPALGY HHHHHHHHHHHHCCC	48.97	21906983
198	Phosphorylation	IFTFAEKYLPALGYS HHHHHHHHHHHCCCC	14.93	23186163
204	Phosphorylation	KYLPALGYSKRVHLM HHHHHCCCCCCEECC	16.33	23312004
205	Phosphorylation	YLPALGYSKRVHLMN HHHHCCCCCCEECCC	16.52	23917254
206	Acetylation	LPALGYSKRVHLMNP HHHCCCCCCEECCCC	50.37	19608861
206	Ubiquitination	LPALGYSKRVHLMNP HHHCCCCCCEECCCC	50.37	21890473
206	Malonylation	LPALGYSKRVHLMNP HHHCCCCCCEECCCC	50.37	26320211
221	Phosphorylation	MVPGLTGSKMSSSEE CCCCCCCCCCCCCHH	21.68	20068231
222	Ubiquitination	VPGLTGSKMSSSEEE CCCCCCCCCCCCHHH	44.11	-
224	Phosphorylation	GLTGSKMSSSEEESK CCCCCCCCCCHHHHH	34.15	29496963
225	Phosphorylation	LTGSKMSSSEEESKI CCCCCCCCCHHHHHH	37.97	30108239
226	Phosphorylation	TGSKMSSSEEESKID CCCCCCCCHHHHHHC	41.54	23186163
230	Phosphorylation	MSSSEEESKIDLLDR CCCCHHHHHHCHHCC	37.89	-
231	Ubiquitination	SSSEEESKIDLLDRK CCCHHHHHHCHHCCH	43.44	-
231	Acetylation	SSSEEESKIDLLDRK CCCHHHHHHCHHCCH	43.44	23236377
237	Methylation	SKIDLLDRKEDVKKK HHHCHHCCHHHHHHH	44.21	115920161
238	Succinylation	KIDLLDRKEDVKKKL HHCHHCCHHHHHHHH	58.91	23954790
244	Acetylation	RKEDVKKKLKKAFCE CHHHHHHHHHHHHCC	60.88	125905199
247	Ubiquitination	DVKKKLKKAFCEPGN HHHHHHHHHHCCCCC	58.07	-
247	Acetylation	DVKKKLKKAFCEPGN HHHHHHHHHHCCCCC	58.07	26051181
250	S-nitrosocysteine	KKLKKAFCEPGNVEN HHHHHHHCCCCCCCC	8.03	-
250	S-nitrosylation	KKLKKAFCEPGNVEN HHHHHHHCCCCCCCC	8.03	19483679
262	Phosphorylation	VENNGVLSFIKHVLF CCCCCHHHHHHHHHH	23.63	24719451
272	Acetylation	KHVLFPLKSEFVILR HHHHHCCCCCEEEEE	48.45	19608861
272	Ubiquitination	KHVLFPLKSEFVILR HHHHHCCCCCEEEEE	48.45	-
279	Methylation	KSEFVILRDEKWGGN CCCEEEEECCCCCCC	38.63	115920165
282	Ubiquitination	FVILRDEKWGGNKTY EEEEECCCCCCCCEE	56.26	-
282	2-Hydroxyisobutyrylation	FVILRDEKWGGNKTY EEEEECCCCCCCCEE	56.26	-
287	Ubiquitination	DEKWGGNKTYTAYVD CCCCCCCCEEEEEEE	46.30	-
292	Phosphorylation	GNKTYTAYVDLEKDF CCCEEEEEEECCCCE	6.16	-
297	Ubiquitination	TAYVDLEKDFAAEVV EEEEECCCCEECEEE	66.50	-
310	Acetylation	VVHPGDLKNSVEVAL EECCCCCCHHHHHHH	52.49	23954790
310	Ubiquitination	VVHPGDLKNSVEVAL EECCCCCCHHHHHHH	52.49	-
319	Acetylation	SVEVALNKLLDPIRE HHHHHHHHHHHHHHH	51.80	23236377
327	Ubiquitination	LLDPIREKFNTPALK HHHHHHHHCCCHHHH	33.78	-
327	Acetylation	LLDPIREKFNTPALK HHHHHHHHCCCHHHH	33.78	27452117
330	Phosphorylation	PIREKFNTPALKKLA HHHHHCCCHHHHHHH	17.05	29083192
334	Ubiquitination	KFNTPALKKLASAAY HCCCHHHHHHHHHCC	48.09	-
334	Malonylation	KFNTPALKKLASAAY HCCCHHHHHHHHHCC	48.09	26320211
334	Acetylation	KFNTPALKKLASAAY HCCCHHHHHHHHHCC	48.09	25953088
335	Ubiquitination	FNTPALKKLASAAYP CCCHHHHHHHHHCCC	50.57	-
335	Malonylation	FNTPALKKLASAAYP CCCHHHHHHHHHCCC	50.57	26320211
338	Phosphorylation	PALKKLASAAYPDPS HHHHHHHHHCCCCHH	24.70	25159151
356	Ubiquitination	PMAKGPAKNSEPEEV CCCCCCCCCCCCCCC	65.23	-
356	Malonylation	PMAKGPAKNSEPEEV CCCCCCCCCCCCCCC	65.23	26320211
358	Phosphorylation	AKGPAKNSEPEEVIP CCCCCCCCCCCCCCC	54.55	21815630
374	Ubiquitination	RLDIRVGKIITVEKH CCEEEECEEEEEEEC	28.25	-
374	Acetylation	RLDIRVGKIITVEKH CCEEEECEEEEEEEC	28.25	25953088
377	Phosphorylation	IRVGKIITVEKHPDA EEECEEEEEEECCCC	26.53	-
380	Ubiquitination	GKIITVEKHPDADSL CEEEEEEECCCCCCE	56.98	-
380	Acetylation	GKIITVEKHPDADSL CEEEEEEECCCCCCE	56.98	26822725
386	Phosphorylation	EKHPDADSLYVEKID EECCCCCCEEEEEEC	24.26	28450419
388	Phosphorylation	HPDADSLYVEKIDVG CCCCCCEEEEEECCC	15.54	28796482
391	Ubiquitination	ADSLYVEKIDVGEAE CCCEEEEEECCCCCC	33.88	21906983
400	Methylation	DVGEAEPRTVVSGLV CCCCCCCCEEEEEEE	31.49	115920169
412	Ubiquitination	GLVQFVPKEELQDRL EEEEECCHHHHHHCE	59.52	21906983
412	Acetylation	GLVQFVPKEELQDRL EEEEECCHHHHHHCE	59.52	26051181
418	Methylation	PKEELQDRLVVVLCN CHHHHHHCEEEEEEC	19.20	115920173
427	Ubiquitination	VVVLCNLKPQKMRGV EEEEECCCCHHCCCC	31.26	-
427	Malonylation	VVVLCNLKPQKMRGV EEEEECCCCHHCCCC	31.26	26320211
427	Acetylation	VVVLCNLKPQKMRGV EEEEECCCCHHCCCC	31.26	25953088
430	Ubiquitination	LCNLKPQKMRGVESQ EECCCCHHCCCCCCC	38.81	-
430	Acetylation	LCNLKPQKMRGVESQ EECCCCHHCCCCCCC	38.81	26051181
432	Methylation	NLKPQKMRGVESQGM CCCCHHCCCCCCCCC	53.71	115920177
436	Phosphorylation	QKMRGVESQGMLLCA HHCCCCCCCCCEEHH	29.63	-
439	Sulfoxidation	RGVESQGMLLCASIE CCCCCCCCEEHHHHC	1.68	21406390
442	Glutathionylation	ESQGMLLCASIEGIN CCCCCEEHHHHCCCC	2.16	22555962
444	Phosphorylation	QGMLLCASIEGINRQ CCCEEHHHHCCCCCC	21.85	28348404
470	Ubiquitination	PGEHVFVKGYEKGQP CCCEEEEECCCCCCC	44.29	21906983
470	Acetylation	PGEHVFVKGYEKGQP CCCEEEEECCCCCCC	44.29	23236377
474	Acetylation	VFVKGYEKGQPDEEL EEEECCCCCCCCCCC	55.13	19608861
474	Ubiquitination	VFVKGYEKGQPDEEL EEEECCCCCCCCCCC	55.13	19608861
474	Malonylation	VFVKGYEKGQPDEEL EEEECCCCCCCCCCC	55.13	26320211
482	Acetylation	GQPDEELKPKKKVFE CCCCCCCCCCHHHHH	59.06	19608861
482	Ubiquitination	GQPDEELKPKKKVFE CCCCCCCCCCHHHHH	59.06	-
482	Malonylation	GQPDEELKPKKKVFE CCCCCCCCCCHHHHH	59.06	26320211
484	2-Hydroxyisobutyrylation	PDEELKPKKKVFEKL CCCCCCCCHHHHHHH	64.73	-
490	Acetylation	PKKKVFEKLQADFKI CCHHHHHHHHHHHCC	34.14	19608861
490	Ubiquitination	PKKKVFEKLQADFKI CCHHHHHHHHHHHCC	34.14	19608861
490	2-Hydroxyisobutyrylation	PKKKVFEKLQADFKI CCHHHHHHHHHHHCC	34.14	-
490	Malonylation	PKKKVFEKLQADFKI CCHHHHHHHHHHHCC	34.14	26320211
501	S-nitrosocysteine	DFKISEECIAQWKQT HHCCCHHHHHHHHHC	2.47	-
501	Glutathionylation	DFKISEECIAQWKQT HHCCCHHHHHHHHHC	2.47	22555962
501	S-nitrosylation	DFKISEECIAQWKQT HHCCCHHHHHHHHHC	2.47	19483679
506	Ubiquitination	EECIAQWKQTNFMTK HHHHHHHHHCCHHHH	34.85	-
506	Acetylation	EECIAQWKQTNFMTK HHHHHHHHHCCHHHH	34.85	26051181
513	Ubiquitination	KQTNFMTKLGSISCK HHCCHHHHHCCEECC	38.78	21906983
513	Acetylation	KQTNFMTKLGSISCK HHCCHHHHHCCEECC	38.78	25953088
516	Phosphorylation	NFMTKLGSISCKSLK CHHHHHCCEECCCCC	23.05	23312004
518	Phosphorylation	MTKLGSISCKSLKGG HHHHCCEECCCCCCC	19.72	23312004
520	Ubiquitination	KLGSISCKSLKGGNI HHCCEECCCCCCCCC	52.62	-
520	Acetylation	KLGSISCKSLKGGNI HHCCEECCCCCCCCC	52.62	25953088
521	Phosphorylation	LGSISCKSLKGGNIS HCCEECCCCCCCCCC	39.37	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SYYC_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SYYC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SYYC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NRDC_HUMAN	NRD1	physical	22863883
SARNP_HUMAN	SARNP	physical	22863883
DDB1_HUMAN	DDB1	physical	26344197
EIF1B_HUMAN	EIF1B	physical	26344197
G3BP2_HUMAN	G3BP2	physical	26344197
HNRH2_HUMAN	HNRNPH2	physical	26344197
NAA10_HUMAN	NAA10	physical	26344197
NAA15_HUMAN	NAA15	physical	26344197
PLPHP_HUMAN	PROSC	physical	26344197
TATD1_HUMAN	TATDN1	physical	26344197
SYYM_HUMAN	YARS2	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 608323: Charcot-Marie-Tooth disease, dominant, intermediate type, C (CMTDIC)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00135: L-Tyrosine

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-197; LYS-206; LYS-272;LYS-474; LYS-482 AND LYS-490, AND MASS SPECTROMETRY.
PubMed: 19608861