TATD1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TATD1_HUMAN
• UniProt AC: Q6P1N9
• Protein Name: Putative deoxyribonuclease TATDN1
• Gene Name: TATDN1
• Organism: Homo sapiens (Human).
• Sequence Length: 297
• Subcellular Localization: Nucleus .
• Protein Description: Putative deoxyribonuclease..
• Protein Sequence: MSRFKFIDIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDALHLAQTNGMFFSTVGCHPTRCGEFEKNNPDLYLKELLNLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMKRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFPGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	IDIGINLTDPMFRGI EEECCCCCCHHHHHH	33.30	-
27	Acetylation	GIYRGVQKHQDDLQD HHHHHHHHCHHHHHH	40.61	23954790
27	Succinylation	GIYRGVQKHQDDLQD HHHHHHHHCHHHHHH	40.61	-
27	Ubiquitination	GIYRGVQKHQDDLQD HHHHHHHHCHHHHHH	40.61	21906983
27 (in isoform 1)	Ubiquitination	-	40.61	21906983
27	Succinylation	GIYRGVQKHQDDLQD HHHHHHHHCHHHHHH	40.61	-
45	Ubiquitination	RAVEIGVKKFMITGG HHHHHCCCEEEEECC	34.77	21906983
45 (in isoform 1)	Ubiquitination	-	34.77	21906983
46	Succinylation	AVEIGVKKFMITGGN HHHHCCCEEEEECCC	37.45	-
46	Ubiquitination	AVEIGVKKFMITGGN HHHHCCCEEEEECCC	37.45	21906983
46 (in isoform 1)	Ubiquitination	-	37.45	21906983
46	Acetylation	AVEIGVKKFMITGGN HHHHCCCEEEEECCC	37.45	25953088
46	Succinylation	AVEIGVKKFMITGGN HHHHCCCEEEEECCC	37.45	-
47 (in isoform 2)	Ubiquitination	-	3.38	21906983
57 (in isoform 2)	Ubiquitination	-	21.34	21906983
59 (in isoform 2)	Ubiquitination	-	59.31	-
83 (in isoform 2)	Ubiquitination	-	55.01	21906983
86	Ubiquitination	TRCGEFEKNNPDLYL CCCCHHHHCCHHHHH	68.31	-
87 (in isoform 2)	Ubiquitination	-	59.05	21906983
94 (in isoform 1)	Ubiquitination	-	32.53	21906983
94	Ubiquitination	NNPDLYLKELLNLAE CCHHHHHHHHHHHHH	32.53	21906983
104 (in isoform 1)	Ubiquitination	-	72.23	21906983
104	Ubiquitination	LNLAENNKGKVVAIG HHHHHHCCCCEEEEE	72.23	21906983
106	Ubiquitination	LAENNKGKVVAIGEC HHHHCCCCEEEEEEC	34.84	-
115 (in isoform 2)	Ubiquitination	-	10.04	21906983
125	Acetylation	DRLQFCPKDTQLKYF CCCEECCCCHHHHHH	74.68	26051181
130	Ubiquitination	CPKDTQLKYFEKQFE CCCCHHHHHHHHHHC	37.77	21906983
130 (in isoform 1)	Ubiquitination	-	37.77	21906983
130	Acetylation	CPKDTQLKYFEKQFE CCCCHHHHHHHHHHC	37.77	25038526
134	Ubiquitination	TQLKYFEKQFELSEQ HHHHHHHHHHCCCCC	50.84	21906983
134 (in isoform 1)	Ubiquitination	-	50.84	21906983
162	Ubiquitination	AEFLDIMKRNRDRCV HHHHHHHHHCCCCEE	47.02	21906983
162 (in isoform 1)	Ubiquitination	-	47.02	21906983
163 (in isoform 2)	Ubiquitination	-	26.49	21906983
189 (in isoform 2)	Ubiquitination	-	3.76	21906983
210	Ubiquitination	EANLEVLKSIPSEKL HHHHHHHHHCCCHHE	52.06	21906983
210 (in isoform 1)	Ubiquitination	-	52.06	21906983
214	Phosphorylation	EVLKSIPSEKLMIET HHHHHCCCHHEEEEC	45.77	22817900
221	Phosphorylation	SEKLMIETDAPWCGV CHHEEEECCCCCCCC	26.91	29083192
229	Malonylation	DAPWCGVKSTHAGSK CCCCCCCCCCCCCCC	34.61	26320211
229	Ubiquitination	DAPWCGVKSTHAGSK CCCCCCCCCCCCCCC	34.61	-
229	Acetylation	DAPWCGVKSTHAGSK CCCCCCCCCCCCCCC	34.61	25953088
230	Phosphorylation	APWCGVKSTHAGSKY CCCCCCCCCCCCCCH	24.02	29083192
231	Phosphorylation	PWCGVKSTHAGSKYI CCCCCCCCCCCCCHH	15.27	29083192
235	Phosphorylation	VKSTHAGSKYIRTAF CCCCCCCCCHHHHCC	24.06	29083192
236 (in isoform 1)	Ubiquitination	-	43.72	21906983
236	Ubiquitination	KSTHAGSKYIRTAFP CCCCCCCCHHHHCCC	43.72	2190698

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TATD1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TATD1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TATD1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AL1B1_HUMAN	ALDH1B1	physical	22863883
PUR9_HUMAN	ATIC	physical	22863883
CAN2_HUMAN	CAPN2	physical	22863883
FUMH_HUMAN	FH	physical	22863883
HEXB_HUMAN	HEXB	physical	22863883
MOES_HUMAN	MSN	physical	22863883
ULA1_HUMAN	NAE1	physical	22863883
NSF1C_HUMAN	NSFL1C	physical	22863883
LIS1_HUMAN	PAFAH1B1	physical	22863883
PA1B2_HUMAN	PAFAH1B2	physical	22863883
PAPS1_HUMAN	PAPSS1	physical	22863883
PDC10_HUMAN	PDCD10	physical	22863883
IPP2_HUMAN	PPP1R2	physical	22863883
PLPHP_HUMAN	PROSC	physical	22863883
PTMA_HUMAN	PTMA	physical	22863883
GDS1_HUMAN	RAP1GDS1	physical	22863883
UBR7_HUMAN	UBR7	physical	22863883
ARFG2_HUMAN	ARFGAP2	physical	26344197
PUR2_HUMAN	GART	physical	26344197
I2BP1_HUMAN	IRF2BP1	physical	26344197
ECM29_HUMAN	KIAA0368	physical	26344197
LONM_HUMAN	LONP1	physical	26344197
SPD2B_HUMAN	SH3PXD2B	physical	26344197
UBC9_HUMAN	UBE2I	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.