dbPTM

YETS2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	YETS2_HUMAN
UniProt AC	Q9ULM3
Protein Name	YEATS domain-containing protein 2 {ECO:0000305}
Gene Name	YEATS2 {ECO:0000312\|HGNC:HGNC:25489}
Organism	Homo sapiens (Human).
Sequence Length	1422
Subcellular Localization	Nucleus .
Protein Description	Chromatin reader component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. YEATS2 specifically recognizes and binds histone H3 crotonylated at 'Lys-27' (H3K27cr). [PubMed: 27103431 Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors]
Protein Sequence	MSGIKRTIKETDPDYEDVSVALPNKRHKAIENSARDAAVQKIETIIKEQFALEMKNKEHEIEVIDQRLIEARRMMDKLRACIVANYYASAGLLKVSEGSKTCDTMVFNHPAIKKFLESPSRSSSPANQRAETPSANHSESDSLSQHNDFLSDKDNNSNMDIEERLSNNMEQRPSRNTGRDTSRITGSHKTEQRNADLTDETSRLFVKKTIVVGNVSKYIPPDKREENDQSTHKWMVYVRGSRREPSINHFVKKVWFFLHPSYKPNDLVEVREPPFHLTRRGWGEFPVRVQVHFKDSQNKRIDIIHNLKLDRTYTGLQTLGAETVVDVELHRHSLGEDCIYPQSSESDISDAPPSLPLTIPAPVKASSPIKQSHEPVPDTSVEKGFPASTEAERHTPFYALPSSLERTPTKMTTSQKVTFCSHGNSAFQPIASSCKIVPQSQVPNPESPGKSFQPITMSCKIVSGSPISTPSPSPLPRTPTSTPVHVKQGTAGSVINNPYVIMDKQPGQVIGATTPSTGSPTNKISTASQVSQGTGSPVPKIHGSSFVTSTVKQEDSLFASMPPLCPIGSHPKVQSPKPITGGLGAFTKVIIKQEPGEAPHVPATGAASQSPLPQYVTVKGGHMIAVSPQKQVITPGEGIAQSAKVQPSKVVGVPVGSALPSTVKQAVAISGGQILVAKASSSVSKAVGPKQVVTQGVAKAIVSGGGGTIVAQPVQTLTKAQVTAAGPQKSGSQGSVMATLQLPATNLANLANLPPGTKLYLTTNSKNPSGKGKLLLIPQGAILRATNNANLQSGSAASGGSGAGGGGGGGGGGGSGSGGGGSTGGGGGTAGGGTQSTAGPGGISQHLTYTSYILKQTPQGTFLVGQPSPQTSGKQLTTGSVVQGTLGVSTSSAQGQQTLKVISGQKTTLFTQAAHGGQASLMKISDSTLKTVPATSQLSKPGTTMLRVAGGVITTATSPAVALSANGPAQQSEGMAPVSSSTVSSVTKTSGQQQVCVSQATVGTCKAATPTVVSATSLVPTPNPISGKATVSGLLKIHSSQSSPQQAVLTIPSQLKPLSVNTSGGVQTILMPVNKVVQSFSTSKPPAILPVAAPTPVVPSSAPAAVAKVKTEPETPGPSCLSQEGQTAVKTEESSELGNYVIKIDHLETIQQLLTAVVKKIPLITAKSEDASCFSAKSVEQYYGWNIGKRRAAEWQRAMTMRKVLQEILEKNPRFHHLTPLKTKHIAHWCRCHGYTPPDPESLRNDGDSIEDVLTQIDSEPECPSSFSSADNLCRKLEDLQQFQKREPENEEEVDILSLSEPVKINIKKEQEEKQEEVKFYLPPTPGSEFIGDVTQKIGITLQPVALHRNVYASVVEDMILKATEQLVNDILRQALAVGYQTASHNRIPKEITVSNIHQAICNIPFLDFLTNKHMGILNEDQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	Sumoylation	SGIKRTIKETDPDYE CCCCCCCCCCCCCHH	54.68	28112733
11	Phosphorylation	IKRTIKETDPDYEDV CCCCCCCCCCCHHHC	48.07	21945579
15	Phosphorylation	IKETDPDYEDVSVAL CCCCCCCHHHCCEEC	21.29	21945579
19	Phosphorylation	DPDYEDVSVALPNKR CCCHHHCCEECCCHH	17.62	21945579
25	Acetylation	VSVALPNKRHKAIEN CCEECCCHHHHHHHH	54.67	26051181
25	Ubiquitination	VSVALPNKRHKAIEN CCEECCCHHHHHHHH	54.67	29967540
28	Ubiquitination	ALPNKRHKAIENSAR ECCCHHHHHHHHHHH	55.91	29967540
41	Ubiquitination	ARDAAVQKIETIIKE HHHHHHHHHHHHHHH	35.59	29967540
57	Acetylation	FALEMKNKEHEIEVI HHHHCCCCCCEEEHH	55.73	134221
87	Phosphorylation	ACIVANYYASAGLLK HHHHHHHHHHHCCEE	8.22	28555341
100	Acetylation	LKVSEGSKTCDTMVF EEECCCCCCCCEEEE	65.12	25953088
100	Ubiquitination	LKVSEGSKTCDTMVF EEECCCCCCCCEEEE	65.12	29967540
113	Acetylation	VFNHPAIKKFLESPS EECCHHHHHHHHCCC	39.31	25953088
113	Sumoylation	VFNHPAIKKFLESPS EECCHHHHHHHHCCC	39.31	28112733
118	Phosphorylation	AIKKFLESPSRSSSP HHHHHHHCCCCCCCC	30.26	29255136
120	Phosphorylation	KKFLESPSRSSSPAN HHHHHCCCCCCCCCC	54.82	30266825
122	Phosphorylation	FLESPSRSSSPANQR HHHCCCCCCCCCCCC	39.23	25219547
123	Phosphorylation	LESPSRSSSPANQRA HHCCCCCCCCCCCCC	38.95	25219547
124	Phosphorylation	ESPSRSSSPANQRAE HCCCCCCCCCCCCCC	29.31	25159151
132	Phosphorylation	PANQRAETPSANHSE CCCCCCCCCCCCCCC	22.89	29255136
134	Phosphorylation	NQRAETPSANHSESD CCCCCCCCCCCCCCC	49.47	30108239
138	Phosphorylation	ETPSANHSESDSLSQ CCCCCCCCCCCCHHH	38.31	30108239
140	Phosphorylation	PSANHSESDSLSQHN CCCCCCCCCCHHHHH	35.20	30108239
142	Phosphorylation	ANHSESDSLSQHNDF CCCCCCCCHHHHHHH	38.92	30108239
144	Phosphorylation	HSESDSLSQHNDFLS CCCCCCHHHHHHHCC	33.09	17525332
151	Phosphorylation	SQHNDFLSDKDNNSN HHHHHHCCCCCCCCC	42.48	23186163
157	Phosphorylation	LSDKDNNSNMDIEER CCCCCCCCCCCHHHH	39.52	23927012
166	Phosphorylation	MDIEERLSNNMEQRP CCHHHHHHHCCCCCC	32.17	26714015
189	Acetylation	SRITGSHKTEQRNAD HHCCCCCCHHHCCCC	56.29	26051181
189	Sumoylation	SRITGSHKTEQRNAD HHCCCCCCHHHCCCC	56.29	28112733
209	Phosphorylation	SRLFVKKTIVVGNVS HHHEEEEEEEECCHH	17.18	-
216	Phosphorylation	TIVVGNVSKYIPPDK EEEECCHHHCCCCCC	24.60	22210691
234	Ubiquitination	NDQSTHKWMVYVRGS CCCCCCEEEEEECCC	3.63	22817900
239	Ubiquitination	HKWMVYVRGSRREPS CEEEEEECCCCCCCC	21.49	22817900
246	Phosphorylation	RGSRREPSINHFVKK CCCCCCCCHHHHHHE	31.13	-
275	Ubiquitination	VEVREPPFHLTRRGW EECCCCCCEEECCCC	12.33	27667366
308	Ubiquitination	IDIIHNLKLDRTYTG EEEEEECCCCCCCCC	54.37	-
309	Ubiquitination	DIIHNLKLDRTYTGL EEEEECCCCCCCCCH	6.41	21963094
346	Phosphorylation	IYPQSSESDISDAPP CCCCCCCCCCCCCCC	42.04	26074081
349	Phosphorylation	QSSESDISDAPPSLP CCCCCCCCCCCCCCC	32.48	26074081
354	Phosphorylation	DISDAPPSLPLTIPA CCCCCCCCCCEEECC	41.37	26074081
358	Phosphorylation	APPSLPLTIPAPVKA CCCCCCEEECCCCCC	23.99	26074081
366	Phosphorylation	IPAPVKASSPIKQSH ECCCCCCCCCCCCCC	30.81	22167270
367	Phosphorylation	PAPVKASSPIKQSHE CCCCCCCCCCCCCCC	35.19	23401153
370	Sumoylation	VKASSPIKQSHEPVP CCCCCCCCCCCCCCC	49.48	28112733
372	Phosphorylation	ASSPIKQSHEPVPDT CCCCCCCCCCCCCCC	25.47	22167270
379	Phosphorylation	SHEPVPDTSVEKGFP CCCCCCCCCHHCCCC	28.71	24732914
380	Phosphorylation	HEPVPDTSVEKGFPA CCCCCCCCHHCCCCC	35.34	24732914
383	Acetylation	VPDTSVEKGFPASTE CCCCCHHCCCCCCCC	64.79	26051181
383	Ubiquitination	VPDTSVEKGFPASTE CCCCCHHCCCCCCCC	64.79	29967540
388	Phosphorylation	VEKGFPASTEAERHT HHCCCCCCCCHHHCC	27.33	28348404
389	O-linked_Glycosylation	EKGFPASTEAERHTP HCCCCCCCCHHHCCC	41.12	30059200
389	Phosphorylation	EKGFPASTEAERHTP HCCCCCCCCHHHCCC	41.12	28348404
395	Phosphorylation	STEAERHTPFYALPS CCCHHHCCCCCCCCC	22.70	21945579
398	Phosphorylation	AERHTPFYALPSSLE HHHCCCCCCCCCCCC	14.39	21945579
402	Phosphorylation	TPFYALPSSLERTPT CCCCCCCCCCCCCCC	48.70	23927012
403	Phosphorylation	PFYALPSSLERTPTK CCCCCCCCCCCCCCC	32.10	23401153
407	Phosphorylation	LPSSLERTPTKMTTS CCCCCCCCCCCCCCC	26.40	23927012
408	Phosphorylation	PSSLERTPTKMTTSQ CCCCCCCCCCCCCCC	35.92	32142685
409	Phosphorylation	SSLERTPTKMTTSQK CCCCCCCCCCCCCCE	32.60	23927012
410	Acetylation	SLERTPTKMTTSQKV CCCCCCCCCCCCCEE	35.14	25953088
416	Acetylation	TKMTTSQKVTFCSHG CCCCCCCEEEECCCC	42.90	26051181
432	Phosphorylation	SAFQPIASSCKIVPQ CCCHHCHHCCEEECH	36.67	28555341
435	Acetylation	QPIASSCKIVPQSQV HHCHHCCEEECHHHC	49.00	25953088
440	Phosphorylation	SCKIVPQSQVPNPES CCEEECHHHCCCCCC	27.37	23403867
447	Phosphorylation	SQVPNPESPGKSFQP HHCCCCCCCCCCCCC	39.96	19664994
448	Phosphorylation	QVPNPESPGKSFQPI HCCCCCCCCCCCCCE	53.20	32142685
450	Acetylation	PNPESPGKSFQPITM CCCCCCCCCCCCEEE	52.02	26051181
451	Phosphorylation	NPESPGKSFQPITMS CCCCCCCCCCCEEEE	34.72	26552605
456	Phosphorylation	GKSFQPITMSCKIVS CCCCCCEEEEEEEEE	15.09	30576142
458	Phosphorylation	SFQPITMSCKIVSGS CCCCEEEEEEEEECC	12.01	26552605
460	Acetylation	QPITMSCKIVSGSPI CCEEEEEEEEECCCC	38.54	26051181
463	Phosphorylation	TMSCKIVSGSPISTP EEEEEEEECCCCCCC	36.71	29255136
464	Phosphorylation	MSCKIVSGSPISTPS EEEEEEECCCCCCCC	26.92	32142685
465	Phosphorylation	SCKIVSGSPISTPSP EEEEEECCCCCCCCC	16.14	29255136
466	Phosphorylation	CKIVSGSPISTPSPS EEEEECCCCCCCCCC	28.24	33259812
468	Phosphorylation	IVSGSPISTPSPSPL EEECCCCCCCCCCCC	37.34	30266825
469	Phosphorylation	VSGSPISTPSPSPLP EECCCCCCCCCCCCC	28.62	30266825
471	Phosphorylation	GSPISTPSPSPLPRT CCCCCCCCCCCCCCC	37.79	30266825
473	Phosphorylation	PISTPSPSPLPRTPT CCCCCCCCCCCCCCC	43.32	29255136
478	Phosphorylation	SPSPLPRTPTSTPVH CCCCCCCCCCCCCEE	29.04	23401153
480	Phosphorylation	SPLPRTPTSTPVHVK CCCCCCCCCCCEEEC	44.62	30266825
481	Phosphorylation	PLPRTPTSTPVHVKQ CCCCCCCCCCEEECC	31.73	30266825
482	Phosphorylation	LPRTPTSTPVHVKQG CCCCCCCCCEEECCC	31.63	30266825
487	Sumoylation	TSTPVHVKQGTAGSV CCCCEEECCCCCCCC	28.29	28112733
490	Phosphorylation	PVHVKQGTAGSVINN CEEECCCCCCCCCCC	25.92	26074081
493	Phosphorylation	VKQGTAGSVINNPYV ECCCCCCCCCCCCEE	19.84	26074081
499	Phosphorylation	GSVINNPYVIMDKQP CCCCCCCEEEEECCC	12.53	26074081
513	Phosphorylation	PGQVIGATTPSTGSP CCCEEEEECCCCCCC	33.74	25159151
514	Phosphorylation	GQVIGATTPSTGSPT CCEEEEECCCCCCCC	18.08	30266825
516	Phosphorylation	VIGATTPSTGSPTNK EEEEECCCCCCCCCC	43.22	30266825
517	Phosphorylation	IGATTPSTGSPTNKI EEEECCCCCCCCCCC	42.77	30266825
519	Phosphorylation	ATTPSTGSPTNKIST EECCCCCCCCCCCCC	28.74	29255136
521	Phosphorylation	TPSTGSPTNKISTAS CCCCCCCCCCCCCHH	51.33	30266825
525	Phosphorylation	GSPTNKISTASQVSQ CCCCCCCCCHHHHCC	21.38	23403867
526	Phosphorylation	SPTNKISTASQVSQG CCCCCCCCHHHHCCC	33.53	23403867
528	Phosphorylation	TNKISTASQVSQGTG CCCCCCHHHHCCCCC	31.07	23403867
531	Phosphorylation	ISTASQVSQGTGSPV CCCHHHHCCCCCCCC	18.43	29255136
534	Phosphorylation	ASQVSQGTGSPVPKI HHHHCCCCCCCCCEE	27.18	29255136
536	Phosphorylation	QVSQGTGSPVPKIHG HHCCCCCCCCCEECC	23.67	19664994
545	Phosphorylation	VPKIHGSSFVTSTVK CCEECCCCCCCEEEC	28.47	25159151
548	Phosphorylation	IHGSSFVTSTVKQED ECCCCCCCEEECHHC	19.37	20860994
550	Phosphorylation	GSSFVTSTVKQEDSL CCCCCCEEECHHCCC	23.51	20860994
552	Sumoylation	SFVTSTVKQEDSLFA CCCCEEECHHCCCCC	48.32	28112733
575	Phosphorylation	GSHPKVQSPKPITGG CCCCCCCCCCCCCCC	37.57	25159151
576	Phosphorylation	SHPKVQSPKPITGGL CCCCCCCCCCCCCCC	29.38	32142685
577	Acetylation	HPKVQSPKPITGGLG CCCCCCCCCCCCCCC	55.06	26051181
580	Phosphorylation	VQSPKPITGGLGAFT CCCCCCCCCCCCCEE	33.45	30266825
587	O-linked_Glycosylation	TGGLGAFTKVIIKQE CCCCCCEEEEEEECC	24.70	30059200
587	Phosphorylation	TGGLGAFTKVIIKQE CCCCCCEEEEEEECC	24.70	23403867
591	Ubiquitination	GAFTKVIIKQEPGEA CCEEEEEEECCCCCC	4.17	22817900
592	Sumoylation	AFTKVIIKQEPGEAP CEEEEEEECCCCCCC	37.17	-
592	Sumoylation	AFTKVIIKQEPGEAP CEEEEEEECCCCCCC	37.17	28112733
592	Ubiquitination	AFTKVIIKQEPGEAP CEEEEEEECCCCCCC	37.17	22817900
596	Ubiquitination	VIIKQEPGEAPHVPA EEEECCCCCCCCCCC	42.84	22817900
597	Ubiquitination	IIKQEPGEAPHVPAT EEECCCCCCCCCCCC	70.51	22817900
604	O-linked_Glycosylation	EAPHVPATGAASQSP CCCCCCCCCCCCCCC	22.68	30059200
604	Phosphorylation	EAPHVPATGAASQSP CCCCCCCCCCCCCCC	22.68	27732954
608	Phosphorylation	VPATGAASQSPLPQY CCCCCCCCCCCCCCE	30.56	28985074
610	Phosphorylation	ATGAASQSPLPQYVT CCCCCCCCCCCCEEE	26.38	27050516
615	Phosphorylation	SQSPLPQYVTVKGGH CCCCCCCEEEEECCE	8.99	27732954
617	Phosphorylation	SPLPQYVTVKGGHMI CCCCCEEEEECCEEE	16.15	27732954
627	Phosphorylation	GGHMIAVSPQKQVIT CCEEEEECCCCCEEC	16.76	25159151
628	Phosphorylation	GHMIAVSPQKQVITP CEEEEECCCCCEECC	38.50	32645325
630	Acetylation	MIAVSPQKQVITPGE EEEECCCCCEECCCC	50.33	25953088
632	Ubiquitination	AVSPQKQVITPGEGI EECCCCCEECCCCCH	7.29	27667366
633	Ubiquitination	VSPQKQVITPGEGIA ECCCCCEECCCCCHH	3.40	27667366
634	Phosphorylation	SPQKQVITPGEGIAQ CCCCCEECCCCCHHH	26.78	24732914
642	Phosphorylation	PGEGIAQSAKVQPSK CCCCHHHCCCCCCCC	22.49	25404012
644	Ubiquitination	EGIAQSAKVQPSKVV CCHHHCCCCCCCCEE	46.80	22817900
645	Ubiquitination	GIAQSAKVQPSKVVG CHHHCCCCCCCCEEC	11.49	22817900
649	Sumoylation	SAKVQPSKVVGVPVG CCCCCCCCEECEECC	47.85	28112733
649	Ubiquitination	SAKVQPSKVVGVPVG CCCCCCCCEECEECC	47.85	22817900
650	Ubiquitination	AKVQPSKVVGVPVGS CCCCCCCEECEECCC	5.48	22817900
657	Phosphorylation	VVGVPVGSALPSTVK EECEECCCCCCHHHH	27.20	-
666	Ubiquitination	LPSTVKQAVAISGGQ CCHHHHHHHEECCCC	6.23	21963094
667	Ubiquitination	PSTVKQAVAISGGQI CHHHHHHHEECCCCE	4.50	21963094
685	Ubiquitination	KASSSVSKAVGPKQV ECCCCCHHCCCCHHE	44.96	27667366
686	Ubiquitination	ASSSVSKAVGPKQVV CCCCCHHCCCCHHEE	12.18	27667366
690	Ubiquitination	VSKAVGPKQVVTQGV CHHCCCCHHEEEHHH	50.20	29967540
699	Acetylation	VVTQGVAKAIVSGGG EEEHHHEEEEEECCC	35.92	26051181
703	O-linked_Glycosylation	GVAKAIVSGGGGTIV HHEEEEEECCCCEEE	26.13	30059200
719	Ubiquitination	QPVQTLTKAQVTAAG CCCCCCCEEEEEEEC	39.68	21963094
720	Ubiquitination	PVQTLTKAQVTAAGP CCCCCCEEEEEEECC	12.11	21963094
765	Phosphorylation	KLYLTTNSKNPSGKG EEEEEECCCCCCCCC	31.55	17192257
766	Ubiquitination	LYLTTNSKNPSGKGK EEEEECCCCCCCCCE	74.97	29967540
773	Sumoylation	KNPSGKGKLLLIPQG CCCCCCCEEEEECCC	39.17	-
773	Acetylation	KNPSGKGKLLLIPQG CCCCCCCEEEEECCC	39.17	25953088
773	Sumoylation	KNPSGKGKLLLIPQG CCCCCCCEEEEECCC	39.17	28112733
773	Ubiquitination	KNPSGKGKLLLIPQG CCCCCCCEEEEECCC	39.17	-
829	Phosphorylation	STGGGGGTAGGGTQS CCCCCCCCCCCCCCC	25.96	24275569
834	Phosphorylation	GGTAGGGTQSTAGPG CCCCCCCCCCCCCCC	23.71	24275569
836	Phosphorylation	TAGGGTQSTAGPGGI CCCCCCCCCCCCCCC	21.77	24275569
837	Phosphorylation	AGGGTQSTAGPGGIS CCCCCCCCCCCCCCH	26.30	24275569
844	Phosphorylation	TAGPGGISQHLTYTS CCCCCCCHHHEEEEE	18.15	24275569
848	Phosphorylation	GGISQHLTYTSYILK CCCHHHEEEEEEEEE	23.72	24275569
850	Phosphorylation	ISQHLTYTSYILKQT CHHHEEEEEEEEEEC	15.15	24275569
851	Phosphorylation	SQHLTYTSYILKQTP HHHEEEEEEEEEECC	10.36	24275569
868	Phosphorylation	TFLVGQPSPQTSGKQ EEEECCCCCCCCCCC	23.04	25159151
872	Phosphorylation	GQPSPQTSGKQLTTG CCCCCCCCCCCCCCC	38.45	28985074
875	Ubiquitination	SPQTSGKQLTTGSVV CCCCCCCCCCCCCEE	47.79	22817900
903	Phosphorylation	QQTLKVISGQKTTLF CEEEEEECCCCEEEE	37.85	19413330
911	Phosphorylation	GQKTTLFTQAAHGGQ CCCEEEEEECCCCCC	22.02	19413330
923	Sumoylation	GGQASLMKISDSTLK CCCCEEEEECCCCCC	44.33	28112733
923	Ubiquitination	GGQASLMKISDSTLK CCCCEEEEECCCCCC	44.33	-
925	Phosphorylation	QASLMKISDSTLKTV CCEEEEECCCCCCCC	21.71	27251275
927	Phosphorylation	SLMKISDSTLKTVPA EEEEECCCCCCCCCC	28.93	21815630
930	Acetylation	KISDSTLKTVPATSQ EECCCCCCCCCCCCC	47.79	23236377
930	Ubiquitination	KISDSTLKTVPATSQ EECCCCCCCCCCCCC	47.79	-
931	Phosphorylation	ISDSTLKTVPATSQL ECCCCCCCCCCCCCC	34.53	28857561
935	Phosphorylation	TLKTVPATSQLSKPG CCCCCCCCCCCCCCC	15.78	28857561
939	Phosphorylation	VPATSQLSKPGTTML CCCCCCCCCCCCEEE	29.21	24247654
940	Acetylation	PATSQLSKPGTTMLR CCCCCCCCCCCEEEE	56.93	26051181
940	Ubiquitination	PATSQLSKPGTTMLR CCCCCCCCCCCEEEE	56.93	-
989	O-linked_Glycosylation	TVSSVTKTSGQQQVC CEEEEECCCCCEEEE	28.82	30059200
990	O-linked_Glycosylation	VSSVTKTSGQQQVCV EEEEECCCCCEEEEE	35.84	30059200
998	O-linked_Glycosylation	GQQQVCVSQATVGTC CCEEEEEEECEECCC	14.68	30059200
1009	Phosphorylation	VGTCKAATPTVVSAT ECCCCCCCCEEEEEE	25.09	25627689
1011	Phosphorylation	TCKAATPTVVSATSL CCCCCCCEEEEEEEE	29.23	25627689
1021	Phosphorylation	SATSLVPTPNPISGK EEEEECCCCCCCCCC	28.37	-
1039	Phosphorylation	SGLLKIHSSQSSPQQ HEEEEEECCCCCCCE	33.28	20068231
1040	Phosphorylation	GLLKIHSSQSSPQQA EEEEEECCCCCCCEE	21.66	20068231
1042	Phosphorylation	LKIHSSQSSPQQAVL EEEECCCCCCCEEEE	46.03	25627689
1043	Phosphorylation	KIHSSQSSPQQAVLT EEECCCCCCCEEEEE	21.06	20068231
1062	Phosphorylation	LKPLSVNTSGGVQTI CCCCEEECCCCCEEE	26.96	22468782
1068	Phosphorylation	NTSGGVQTILMPVNK ECCCCCEEEEEEHHH	17.42	-
1082	Phosphorylation	KVVQSFSTSKPPAIL HHHHHCCCCCCCCEE	38.47	22468782
1083	Phosphorylation	VVQSFSTSKPPAILP HHHHCCCCCCCCEEE	41.80	22468782
1084	Ubiquitination	VQSFSTSKPPAILPV HHHCCCCCCCCEEEE	55.92	-
1110	Sumoylation	PAAVAKVKTEPETPG CCEEEECCCCCCCCC	46.60	-
1110	Acetylation	PAAVAKVKTEPETPG CCEEEECCCCCCCCC	46.60	26051181
1110	Sumoylation	PAAVAKVKTEPETPG CCEEEECCCCCCCCC	46.60	25114211
1115	Phosphorylation	KVKTEPETPGPSCLS ECCCCCCCCCCCCCC	44.24	28857561
1122	Phosphorylation	TPGPSCLSQEGQTAV CCCCCCCCCCCCEEE	30.43	22817900
1130	Sumoylation	QEGQTAVKTEESSEL CCCCEEEECCCCCCC	47.99	28112733
1131	Phosphorylation	EGQTAVKTEESSELG CCCEEEECCCCCCCC	38.08	20044836
1134	Phosphorylation	TAVKTEESSELGNYV EEEECCCCCCCCCEE	23.92	20044836
1135	Phosphorylation	AVKTEESSELGNYVI EEECCCCCCCCCEEE	39.87	20044836
1159	Ubiquitination	QLLTAVVKKIPLITA HHHHHHHHHCCEEEE	38.08	-
1160	Ubiquitination	LLTAVVKKIPLITAK HHHHHHHHCCEEEEC	37.64	-
1165	Phosphorylation	VKKIPLITAKSEDAS HHHCCEEEECCCCCC	35.40	-
1168	Phosphorylation	IPLITAKSEDASCFS CCEEEECCCCCCCCC	37.94	-
1172	Phosphorylation	TAKSEDASCFSAKSV EECCCCCCCCCCCHH	28.19	-
1177	Acetylation	DASCFSAKSVEQYYG CCCCCCCCHHHHHHC	54.56	26051181
1219	Phosphorylation	NPRFHHLTPLKTKHI CCCCCCCCCCCCHHH	23.40	28112733
1222	Sumoylation	FHHLTPLKTKHIAHW CCCCCCCCCHHHHHH	57.65	28112733
1222	Ubiquitination	FHHLTPLKTKHIAHW CCCCCCCCCHHHHHH	57.65	29967540
1232	Ubiquitination	HIAHWCRCHGYTPPD HHHHHHHCCCCCCCC	2.37	22817900
1233	Ubiquitination	IAHWCRCHGYTPPDP HHHHHHCCCCCCCCH	16.97	22817900
1249	Phosphorylation	SLRNDGDSIEDVLTQ HHCCCCCCHHHHHHH	33.15	20068231
1255	Phosphorylation	DSIEDVLTQIDSEPE CCHHHHHHHCCCCCC	24.27	20068231
1259	Phosphorylation	DVLTQIDSEPECPSS HHHHHCCCCCCCCCC	57.59	20068231
1265	Phosphorylation	DSEPECPSSFSSADN CCCCCCCCCCCHHHH	56.53	20068231
1266	Phosphorylation	SEPECPSSFSSADNL CCCCCCCCCCHHHHH	17.81	20068231
1268	Phosphorylation	PECPSSFSSADNLCR CCCCCCCCHHHHHHH	26.94	20068231
1269	Phosphorylation	ECPSSFSSADNLCRK CCCCCCCHHHHHHHH	37.32	20068231
1276	Ubiquitination	SADNLCRKLEDLQQF HHHHHHHHHHHHHHH	56.05	29967540
1285	Sumoylation	EDLQQFQKREPENEE HHHHHHHHCCCCCHH	61.08	28112733
1285	Ubiquitination	EDLQQFQKREPENEE HHHHHHHHCCCCCHH	61.08	22817900
1286	Ubiquitination	DLQQFQKREPENEEE HHHHHHHCCCCCHHH	54.65	22817900
1304	Ubiquitination	LSLSEPVKINIKKEQ EECCCCEEEECCHHH	40.53	29967540
1308	Acetylation	EPVKINIKKEQEEKQ CCEEEECCHHHHHHH	45.85	7959899
1309	Acetylation	PVKINIKKEQEEKQE CEEEECCHHHHHHHH	61.91	7959911
1352	Phosphorylation	VALHRNVYASVVEDM EECCCCHHHHHHHHH	9.19	22817900
1354	Phosphorylation	LHRNVYASVVEDMIL CCCCHHHHHHHHHHH	14.70	30243723
1364	Phosphorylation	EDMILKATEQLVNDI HHHHHHHHHHHHHHH	23.76	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of YETS2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of YETS2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of YETS2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZZZ3_HUMAN	ZZZ3	physical	18838386
UBP2L_HUMAN	UBAP2L	physical	18838386
CSR2B_HUMAN	CSRP2BP	physical	18838386
KAT2A_HUMAN	KAT2A	physical	18838386
KAT2B_HUMAN	KAT2B	physical	18838386
M3K7_HUMAN	MAP3K7	physical	18838386
TADA3_HUMAN	TADA3	physical	18838386
TAD2A_HUMAN	TADA2A	physical	18838386
MBIP1_HUMAN	MBIP	physical	18838386
WDR5_HUMAN	WDR5	physical	18838386
SGF29_HUMAN	CCDC101	physical	18838386
NC2B_HUMAN	DR1	physical	18838386
DPOE3_HUMAN	POLE3	physical	18838386
DPOE4_HUMAN	POLE4	physical	18838386

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of YETS2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-536, AND MASSSPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-447; SER-463; SER-465;SER-473; SER-519; THR-521 AND SER-536, AND MASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118, AND MASSSPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-765, AND MASSSPECTROMETRY.	18691976 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, AND MASSSPECTROMETRY.	17525332 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; SER-447; SER-465AND SER-519, AND MASS SPECTROMETRY.	15302935 [Abstract]