dbPTM

TAD2A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TAD2A_HUMAN
UniProt AC	O75478
Protein Name	Transcriptional adapter 2-alpha
Gene Name	TADA2A
Organism	Homo sapiens (Human).
Sequence Length	443
Subcellular Localization	Nucleus . Chromosome .
Protein Description	Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. [PubMed: 22644376 May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage]
Protein Sequence	MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSIPMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQMVRLVPGAYLEYKSALLNECNKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKG

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Phosphorylation	--MDRLGPFSNDPSD --CCCCCCCCCCCCC	33.80	23186163
114	Phosphorylation	KEECEKHYMKHFINN HHHHHHHHHHHHHCC	20.94	29083192
126	Phosphorylation	INNPLFASTLLNLKQ HCCHHHHHHHHCHHH	16.56	29083192
127	Phosphorylation	NNPLFASTLLNLKQA CCHHHHHHHHCHHHH	31.66	29083192
132	Sumoylation	ASTLLNLKQAEEAKT HHHHHCHHHHHHHCC	46.52	28112733
132	Ubiquitination	ASTLLNLKQAEEAKT HHHHHCHHHHHHHCC	46.52	-
138	Sumoylation	LKQAEEAKTADTAIP HHHHHHHCCCCCCCC	47.74	28112733
138	Ubiquitination	LKQAEEAKTADTAIP HHHHHHHCCCCCCCC	47.74	-
142	Phosphorylation	EEAKTADTAIPFHST HHHCCCCCCCCCCCC	24.83	24719451
159	Phosphorylation	PPRPTFDSLLSRDMA CCCCCHHHHHCCHHH	27.33	24719451
162	Phosphorylation	PTFDSLLSRDMAGYM CCHHHHHCCHHHCCC	31.37	24719451
211	Phosphorylation	KMAVVDIYHSRLKER HHHHHHHHHHHHHHH	6.84	-
213	Phosphorylation	AVVDIYHSRLKERQR HHHHHHHHHHHHHHH	23.49	-
235	Ubiquitination	HGLINLRKFQLMERR HCCHHHHHHHHHHHH	40.40	-
253	Phosphorylation	EVQDLYETMRRFARI HHHHHHHHHHHHHHH	11.47	-
302	Phosphorylation	TNFCSARTYDHLKKT CCHHCHHHHHHHHHH	32.77	29496907
348	Phosphorylation	ADIDSGLSPSIPMAS CCCCCCCCCCCCCCC	21.81	21815630
355	Phosphorylation	SPSIPMASNSGRRSA CCCCCCCCCCCCCCC	25.85	28555341
361	Phosphorylation	ASNSGRRSAPPLNLT CCCCCCCCCCCCCCC	43.71	30266825
375	Ubiquitination	TGLPGTEKLNEKEKE CCCCCCHHHCHHHHH	57.35	-
381	Ubiquitination	EKLNEKEKELCQMVR HHHCHHHHHHHHHHH	68.03	19608861
381	Acetylation	EKLNEKEKELCQMVR HHHCHHHHHHHHHHH	68.03	19608861
398	Ubiquitination	PGAYLEYKSALLNEC CHHHHHHHHHHHHHH	21.63	-
407	Ubiquitination	ALLNECNKQGGLRLA HHHHHHHHCCCHHHH	63.08	-
421	Ubiquitination	AQARALIKIDVNKTR HHHHHHEEECCCCCH	33.43	-
429	Ubiquitination	IDVNKTRKIYDFLIR ECCCCCHHHHHHHHH	51.34	-
431	Phosphorylation	VNKTRKIYDFLIREG CCCCHHHHHHHHHCC	12.04	29496907

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TAD2A_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TAD2A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TAD2A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EXOC8_HUMAN	EXOC8	physical	16189514
F107A_HUMAN	FAM107A	physical	16189514
HGS_HUMAN	HGS	physical	16189514
TADA3_HUMAN	TADA3	physical	16189514
TADA3_HUMAN	TADA3	physical	11707411
GCR_HUMAN	NR3C1	physical	9649342
KAT2A_HUMAN	KAT2A	physical	9488450
KAT2A_HUMAN	KAT2A	physical	8972232
GCN5_YEAST	GCN5	physical	8972232
NGG1_YEAST	NGG1	physical	12034840
TADA3_MOUSE	Tada3	physical	12034840
CTNB1_HUMAN	CTNNB1	physical	18059173
MED1_HUMAN	MED1	physical	20508642
MED26_HUMAN	MED26	physical	20508642
KAT2A_HUMAN	KAT2A	physical	20508642
SGF29_HUMAN	CCDC101	physical	20508642
XPF_HUMAN	ERCC4	physical	20508642
CDK8_HUMAN	CDK8	physical	20508642
SRSF1_HUMAN	SRSF1	physical	20508642
DDX3X_HUMAN	DDX3X	physical	20508642
LUC7L_HUMAN	LUC7L	physical	20508642
RNF41_HUMAN	RNF41	physical	20508642
DHX16_HUMAN	DHX16	physical	20508642
DDB1_HUMAN	DDB1	physical	20508642
MED29_HUMAN	MED29	physical	20508642
TIF1B_HUMAN	TRIM28	physical	20508642
SNRPA_HUMAN	SNRPA	physical	20508642
LA_HUMAN	SSB	physical	20508642
NCBP1_HUMAN	NCBP1	physical	20508642
PRP6_HUMAN	PRPF6	physical	20508642
PRP17_HUMAN	CDC40	physical	20508642
SRSF3_HUMAN	SRSF3	physical	20508642
WDTC1_HUMAN	WDTC1	physical	20508642
RBM39_HUMAN	RBM39	physical	20508642
MED30_HUMAN	MED30	physical	20508642
MED28_HUMAN	MED28	physical	20508642
PSPC1_HUMAN	PSPC1	physical	20508642
TRA2B_HUMAN	TRA2B	physical	20508642
TRA2A_HUMAN	TRA2A	physical	20508642
RALY_HUMAN	RALY	physical	20508642
NONO_HUMAN	NONO	physical	20508642
PRC2B_HUMAN	PRRC2B	physical	20508642
PLRG1_HUMAN	PLRG1	physical	20508642
HELT_HUMAN	HELT	physical	20508642
SRSF4_HUMAN	SRSF4	physical	20508642
SYF1_HUMAN	XAB2	physical	20508642
MED8_HUMAN	MED8	physical	20508642
PUF60_HUMAN	PUF60	physical	20508642
MED25_HUMAN	MED25	physical	20508642
DHX15_HUMAN	DHX15	physical	20508642
RNPS1_HUMAN	RNPS1	physical	20508642
SRSF5_HUMAN	SRSF5	physical	20508642
EIF3H_HUMAN	EIF3H	physical	20508642
SRRM1_HUMAN	SRRM1	physical	20508642
LRCH4_HUMAN	LRCH4	physical	20508642
MYEF2_HUMAN	MYEF2	physical	20508642
RBM14_HUMAN	RBM14	physical	20508642
EIF3I_HUMAN	EIF3I	physical	20508642
MED20_HUMAN	MED20	physical	20508642
EIF3C_HUMAN	EIF3C	physical	20508642
EIF3M_HUMAN	EIF3M	physical	20508642
SIN3A_HUMAN	SIN3A	physical	20508642
EIF3B_HUMAN	EIF3B	physical	20508642
EIF3L_HUMAN	EIF3L	physical	20508642
PRP19_HUMAN	PRPF19	physical	20508642
HNRPC_HUMAN	HNRNPC	physical	20508642
ILF3_HUMAN	ILF3	physical	20508642
CDC5L_HUMAN	CDC5L	physical	20508642
AKAP8_HUMAN	AKAP8	physical	20508642
MED18_HUMAN	MED18	physical	20508642
SNW1_HUMAN	SNW1	physical	20508642
HDAC1_HUMAN	HDAC1	physical	20508642
MARK3_HUMAN	MARK3	physical	20508642
EMSY_HUMAN	C11orf30	physical	20508642
K2C8_HUMAN	KRT8	physical	20508642
RPB1_HUMAN	POLR2A	physical	20508642
SRRM2_HUMAN	SRRM2	physical	20508642
MED16_HUMAN	MED16	physical	20508642
ILF2_HUMAN	ILF2	physical	20508642
GRP78_HUMAN	HSPA5	physical	20508642
MED14_HUMAN	MED14	physical	20508642
MED31_HUMAN	MED31	physical	20508642
LC7L3_HUMAN	LUC7L3	physical	20508642
DDX5_HUMAN	DDX5	physical	20508642
MED4_HUMAN	MED4	physical	20508642
SFPQ_HUMAN	SFPQ	physical	20508642
MED15_HUMAN	MED15	physical	20508642
MED17_HUMAN	MED17	physical	20508642
DDX17_HUMAN	DDX17	physical	20508642
RPB2_HUMAN	POLR2B	physical	20508642
WDR5_HUMAN	WDR5	physical	20508642
HNRPF_HUMAN	HNRNPF	physical	20508642
ACTC_HUMAN	ACTC1	physical	20508642
DOCK6_HUMAN	DOCK6	physical	20508642
LUZP1_HUMAN	LUZP1	physical	20508642
MED27_HUMAN	MED27	physical	20508642
RPB3_HUMAN	POLR2C	physical	20508642
HNRPM_HUMAN	HNRNPM	physical	20508642
MARK2_HUMAN	MARK2	physical	20508642
MED22_HUMAN	MED22	physical	20508642
MED23_HUMAN	MED23	physical	20508642
ZZZ3_HUMAN	ZZZ3	physical	20508642
MED6_HUMAN	MED6	physical	20508642
MED12_HUMAN	MED12	physical	20508642
MED13_HUMAN	MED13	physical	20508642
HNF4A_HUMAN	HNF4A	physical	9792714
IF4E2_HUMAN	EIF4E2	physical	25416956
MTX2_HUMAN	MTX2	physical	25416956
SYFM_HUMAN	FARS2	physical	25416956
SF3A3_HUMAN	SF3A3	physical	25416956
ZFY26_HUMAN	ZFYVE26	physical	25416956
PP16B_HUMAN	PPP1R16B	physical	25416956
PRP31_HUMAN	PRPF31	physical	25416956
CCHCR_HUMAN	CCHCR1	physical	25416956
CA109_HUMAN	C1orf109	physical	25416956
CDA7L_HUMAN	CDCA7L	physical	25416956
GPSM3_HUMAN	GPSM3	physical	25416956
TTC23_HUMAN	TTC23	physical	25416956
FBF1_HUMAN	FBF1	physical	25416956
KLC4_HUMAN	KLC4	physical	25416956
TEKT4_HUMAN	TEKT4	physical	25416956
ZN564_HUMAN	ZNF564	physical	25416956
TTC9C_HUMAN	TTC9C	physical	25416956
KLH38_HUMAN	KLHL38	physical	25416956
RTL8B_HUMAN	FAM127C	physical	25416956

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TAD2A_HUMAN

Related Literatures of Post-Translational Modification