PLRG1_HUMAN - dbPTM
PLRG1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PLRG1_HUMAN
UniProt AC O43660
Protein Name Pleiotropic regulator 1
Gene Name PLRG1
Organism Homo sapiens (Human).
Sequence Length 514
Subcellular Localization Nucleus . Nucleus speckle .
Protein Description Involved in pre-mRNA splicing as component of the spliceosome. [PubMed: 28502770]
Protein Sequence MVEEVQKHSVHTLVFRSLKRTHDMFVADNGKPVPLDEESHKRKMAIKLRNEYGPVLHMPTSKENLKEKGPQNATDSYVHKQYPANQGQEVEYFVAGTHPYPPGPGVALTADTKIQRMPSESAAQSLAVALPLQTKADANRTAPSGSEYRHPGASDRPQPTAMNSIVMETGNTKNSALMAKKAPTMPKPQWHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVYREDDTATEETHPVSWKPEIIKRKRF
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MVEEVQKH
-------CCHHHHHH		8.4819413330
7Acetylation-MVEEVQKHSVHTLV
-CCHHHHHHCHHHHH		42.9223749302
12PhosphorylationVQKHSVHTLVFRSLK
HHHHCHHHHHHHHCC		23.5923312004
31AcetylationMFVADNGKPVPLDEE
EEECCCCCCCCCCHH		49.4426051181
31UbiquitinationMFVADNGKPVPLDEE
EEECCCCCCCCCCHH		49.4424816145
31 (in isoform 1)Ubiquitination-49.4421890473
31 (in isoform 2)Ubiquitination-49.4421890473
41AcetylationPLDEESHKRKMAIKL
CCCHHHHHHHHHHHH		64.0926051181
47UbiquitinationHKRKMAIKLRNEYGP
HHHHHHHHHHHCCCC		31.68-
52PhosphorylationAIKLRNEYGPVLHMP
HHHHHHCCCCCCCCC		30.2221945579
60PhosphorylationGPVLHMPTSKENLKE
CCCCCCCCCHHHHHH		44.8728555341
62AcetylationVLHMPTSKENLKEKG
CCCCCCCHHHHHHHC		53.7726051181
62UbiquitinationVLHMPTSKENLKEKG
CCCCCCCHHHHHHHC		53.7721906983
62 (in isoform 1)Ubiquitination-53.7721890473
62 (in isoform 2)Ubiquitination-53.7721890473
68UbiquitinationSKENLKEKGPQNATD
CHHHHHHHCCCCCCC		74.4421906983
68 (in isoform 1)Ubiquitination-74.4421890473
68 (in isoform 2)Ubiquitination-74.4421890473
76PhosphorylationGPQNATDSYVHKQYP
CCCCCCCCCCCCCCC		25.3828555341
77NitrationPQNATDSYVHKQYPA
CCCCCCCCCCCCCCC		14.91-
80UbiquitinationATDSYVHKQYPANQG
CCCCCCCCCCCCCCC		41.2921906983
80 (in isoform 1)Ubiquitination-41.2921890473
92PhosphorylationNQGQEVEYFVAGTHP
CCCCEEEEEEEECCC		14.4528796482
97O-linked_GlycosylationVEYFVAGTHPYPPGP
EEEEEEECCCCCCCC		15.2255830677
97PhosphorylationVEYFVAGTHPYPPGP
EEEEEEECCCCCCCC		15.2228796482
113UbiquitinationVALTADTKIQRMPSE
EEEECCCCCEECCCH		37.0721906983
113 (in isoform 1)Ubiquitination-37.0721890473
117SulfoxidationADTKIQRMPSESAAQ
CCCCCEECCCHHHHH		2.1621406390
119PhosphorylationTKIQRMPSESAAQSL
CCCEECCCHHHHHHH		34.5425159151
121PhosphorylationIQRMPSESAAQSLAV
CEECCCHHHHHHHHH		32.9925159151
125PhosphorylationPSESAAQSLAVALPL
CCHHHHHHHHHHHCC		17.3620068231
126UbiquitinationSESAAQSLAVALPLQ
CHHHHHHHHHHHCCC		2.7121963094
126 (in isoform 2)Ubiquitination-2.7121890473
134PhosphorylationAVALPLQTKADANRT
HHHHCCCCCCCCCCC		35.5623186163
135AcetylationVALPLQTKADANRTA
HHHCCCCCCCCCCCC		31.1625953088
135UbiquitinationVALPLQTKADANRTA
HHHCCCCCCCCCCCC		31.1621906983
135 (in isoform 1)Ubiquitination-31.1621890473
141PhosphorylationTKADANRTAPSGSEY
CCCCCCCCCCCCCCC		42.6027080861
144PhosphorylationDANRTAPSGSEYRHP
CCCCCCCCCCCCCCC		53.1127080861
146O-linked_GlycosylationNRTAPSGSEYRHPGA
CCCCCCCCCCCCCCC		35.4730379171
146PhosphorylationNRTAPSGSEYRHPGA
CCCCCCCCCCCCCCC		35.4727080861
148PhosphorylationTAPSGSEYRHPGASD
CCCCCCCCCCCCCCC		18.8727080861
154PhosphorylationEYRHPGASDRPQPTA
CCCCCCCCCCCCCCC		39.8227080861
160PhosphorylationASDRPQPTAMNSIVM
CCCCCCCCCCCCEEE		33.0427080861
164PhosphorylationPQPTAMNSIVMETGN
CCCCCCCCEEEECCC		11.9527080861
164UbiquitinationPQPTAMNSIVMETGN
CCCCCCCCEEEECCC		11.9529967540
164 (in isoform 2)Ubiquitination-11.9521890473
169PhosphorylationMNSIVMETGNTKNSA
CCCEEEECCCCCCCC		20.0327794612
171UbiquitinationSIVMETGNTKNSALM
CEEEECCCCCCCCHH		56.1329967540
173UbiquitinationVMETGNTKNSALMAK
EEECCCCCCCCHHCC		53.5621906983
173 (in isoform 1)Ubiquitination-53.5621890473
175PhosphorylationETGNTKNSALMAKKA
ECCCCCCCCHHCCCC		25.08-
1802-HydroxyisobutyrylationKNSALMAKKAPTMPK
CCCCHHCCCCCCCCC		35.19-
180AcetylationKNSALMAKKAPTMPK
CCCCHHCCCCCCCCC		35.1925953088
180UbiquitinationKNSALMAKKAPTMPK
CCCCHHCCCCCCCCC		35.1929967540
184PhosphorylationLMAKKAPTMPKPQWH
HHCCCCCCCCCCCCC		51.47-
201PhosphorylationWKLYRVISGHLGWVR
CHHHHHHCCCCCEEE		19.8023186163
220 (in isoform 2)Ubiquitination-5.5921890473
228UbiquitinationTGSADRTIKIWDLAS
ECCCCCEEEEEEECC		2.9521890473
228 (in isoform 2)Ubiquitination-2.9521890473
229UbiquitinationGSADRTIKIWDLASG
CCCCCEEEEEEECCC		36.8121906983
229 (in isoform 1)Ubiquitination-36.8121890473
237UbiquitinationIWDLASGKLKLSLTG
EEEECCCCEEEEEEC		39.7021906983
237 (in isoform 1)Ubiquitination-39.7021890473
255PhosphorylationTVRGVIVSTRSPYLF
EEEEEEEECCCCEEE		13.6424732914
256PhosphorylationVRGVIVSTRSPYLFS
EEEEEEECCCCEEEE		25.0324732914
259UbiquitinationVIVSTRSPYLFSCGE
EEEECCCCEEEECCC		26.9327667366
262UbiquitinationSTRSPYLFSCGEDKQ
ECCCCEEEECCCCCE		4.7229967540
268AcetylationLFSCGEDKQVKCWDL
EEECCCCCEEEEEEC		53.3325953088
268UbiquitinationLFSCGEDKQVKCWDL
EEECCCCCEEEEEEC		53.3327667366
271AcetylationCGEDKQVKCWDLEYN
CCCCCEEEEEECCCH		27.4126051181
271UbiquitinationCGEDKQVKCWDLEYN
CCCCCEEEEEECCCH		27.4129967540
277PhosphorylationVKCWDLEYNKVIRHY
EEEEECCCHHHHHHH		27.8128152594
279AcetylationCWDLEYNKVIRHYHG
EEECCCHHHHHHHCC		37.8326051181
279UbiquitinationCWDLEYNKVIRHYHG
EEECCCHHHHHHHCC		37.83-
311UbiquitinationVTCSRDSTARIWDVR
EECCCCCCCEEEEEE		25.0123503661
311 (in isoform 2)Ubiquitination-25.0121890473
320UbiquitinationRIWDVRTKASVHTLS
EEEEEECCEEEEECC		28.2721906983
320 (in isoform 1)Ubiquitination-28.2721890473
354UbiquitinationTGSHDTTIRLWDLVA
ECCCCCEEEHHHHHC		3.5633845483
354 (in isoform 2)Ubiquitination-3.5621890473
363UbiquitinationLWDLVAGKTRVTLTN
HHHHHCCCEEEEECC		24.3421906983
363 (in isoform 1)Ubiquitination-24.3421890473
364PhosphorylationWDLVAGKTRVTLTNH
HHHHCCCEEEEECCC		29.4722210691
372UbiquitinationRVTLTNHKKSVRAVV
EEEECCCCCEEEEEE		49.1429967540
385PhosphorylationVVLHPRHYTFASGSP
EEECCCCEECCCCCC		12.5823186163
386PhosphorylationVLHPRHYTFASGSPD
EECCCCEECCCCCCC		13.4428152594
387UbiquitinationLHPRHYTFASGSPDN
ECCCCEECCCCCCCC		3.9221963094
387 (in isoform 2)Ubiquitination-3.9221890473
389PhosphorylationPRHYTFASGSPDNIK
CCCEECCCCCCCCCC		35.3030108239
390UbiquitinationRHYTFASGSPDNIKQ
CCEECCCCCCCCCCC		39.5122817900
391PhosphorylationHYTFASGSPDNIKQW
CEECCCCCCCCCCCC		26.9525022875
396UbiquitinationSGSPDNIKQWKFPDG
CCCCCCCCCCCCCCC		57.2521963094
396 (in isoform 1)Ubiquitination-57.2521890473
399UbiquitinationPDNIKQWKFPDGSFI
CCCCCCCCCCCCCCE		44.5222817900
445PhosphorylationLWDWRTGYNFQRVHA
EEECCCCCCCEEEEE		16.5228152594
458PhosphorylationHAAVQPGSLDSESGI
EEEECCCCCCCCCCE		35.3726714015
461PhosphorylationVQPGSLDSESGIFAC
ECCCCCCCCCCEEEE		38.6726714015
463PhosphorylationPGSLDSESGIFACAF
CCCCCCCCCEEEEEE		40.9326714015
468GlutathionylationSESGIFACAFDQSES
CCCCEEEEEECCCCC		2.4322555962
478UbiquitinationDQSESRLLTAEADKT
CCCCCCEEEEECCCE		4.0829967540
484AcetylationLLTAEADKTIKVYRE
EEEEECCCEEEEEEC		60.2323236377
484UbiquitinationLLTAEADKTIKVYRE
EEEEECCCEEEEEEC		60.23-
487UbiquitinationAEADKTIKVYREDDT
EECCCEEEEEECCCC		38.1429967540
496UbiquitinationYREDDTATEETHPVS
EECCCCCCCCCCCCC		36.1229967540
496 (in isoform 2)Ubiquitination-36.1221890473
501UbiquitinationTATEETHPVSWKPEI
CCCCCCCCCCCCHHH		29.2929967540
505AcetylationETHPVSWKPEIIKRK
CCCCCCCCHHHHCCC		25.8526051181
505UbiquitinationETHPVSWKPEIIKRK
CCCCCCCCHHHHCCC		25.852190698
505 (in isoform 1)Ubiquitination-25.8521890473
510UbiquitinationSWKPEIIKRKRF---
CCCHHHHCCCCC---		58.4929967540
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
119SPhosphorylationKinaseCHEK1O14757
GPS
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of PLRG1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PLRG1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
PRP19_HUMANPRPF19physical
17353931
CDC5L_HUMANCDC5Lphysical
17353931
SPF27_HUMANBCAS2physical
17353931
CPVL_HUMANCPVLphysical
17353931
CDC5L_HUMANCDC5Lphysical
11544257
ZSCA1_HUMANZSCAN1physical
20211142
IMA1_HUMANKPNA2physical
21385873
IMA5_HUMANKPNA1physical
21385873
PRP19_HUMANPRPF19physical
17276391
U2AF2_HUMANU2AF2physical
21536736
CDC5L_HUMANCDC5Lphysical
20176811
A4_HUMANAPPphysical
21832049
SPF27_HUMANBCAS2physical
22939629
PRP4_HUMANPRPF4physical
22939629
SYF1_HUMANXAB2physical
22939629
RBM39_HUMANRBM39physical
22939629
RU2A_HUMANSNRPA1physical
22939629
SF3A1_HUMANSF3A1physical
22939629
ZCRB1_HUMANZCRB1physical
22939629
RBM14_HUMANRBM14physical
22939629
UCHL5_HUMANUCHL5physical
22939629
RL9_HUMANRPL9physical
22939629
SF3B1_HUMANSF3B1physical
22365833
HNRPM_HUMANHNRNPMphysical
20467437
CDC5L_HUMANCDC5Lphysical
20467437
AP2M1_HUMANAP2M1physical
26344197
SPF27_HUMANBCAS2physical
26344197
CDC5L_HUMANCDC5Lphysical
26344197
ISY1_HUMANISY1physical
26344197
RM40_HUMANMRPL40physical
26344197
PDIA5_HUMANPDIA5physical
26344197
PRP19_HUMANPRPF19physical
26344197
SF3A1_HUMANSF3A1physical
26344197
SF3A2_HUMANSF3A2physical
26344197
SF3B3_HUMANSF3B3physical
26344197
SMD2_HUMANSNRPD2physical
26344197
SNW1_HUMANSNW1physical
26344197
LINES_HUMANLINSphysical
28514442
PRP19_HUMANPRPF19physical
28514442
SPF27_HUMANBCAS2physical
28514442
CDC5L_HUMANCDC5Lphysical
28514442
SYF1_HUMANXAB2physical
28514442
C19L2_HUMANCWF19L2physical
28514442
CRNL1_HUMANCRNKL1physical
28514442
AQR_HUMANAQRphysical
28514442
DHX35_HUMANDHX35physical
28514442
GPTC1_HUMANGPATCH1physical
28514442
ISY1_HUMANISY1physical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of PLRG1_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, AND MASS SPECTROMETRY.

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