LINES_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LINES_HUMAN
• UniProt AC: Q8NG48
• Protein Name: Protein Lines homolog 1 {ECO:0000312|HGNC:HGNC:30922}
• Gene Name: LINS1 {ECO:0000312|HGNC:HGNC:30922}
• Organism: Homo sapiens (Human).
• Sequence Length: 757
• Protein Sequence: MKVFCEVLEELYKKVLLGATLENDSHDYIFYLNPAVSDQDCSTATSLEWANTCGIQGRHQPISVGVAPIAVAPVCLKTNSQMSGSREVMLLQLTVIKVMTTRILSVKTEFHAKEQYRDVIKILLESAKVDSKLICMFQNSDKLLSHMAAQCLALLLYFQLREKITLSNSWIAFCQKNLSEYSESNKAIYCLWTLTAIIKEIFKDSCSQKTEILKQFLTHFDTIFEVFYNSLFSQHFENCRDTSKIVNILMCFLDLLELLIASRIHLKLHFTCQRILFLKPSCMLEVITWPIQAFVKRKVIIFLKKCLLCKVGEDLCRGSVPALMPPDHHVAVDMLALANAVLQAVNSGLLKTLSVYEKHSFFGGDEVQPECELITSPDHVILRAASLVIMKSLEIKFQNYSSASEVKVDLQRFMSELLTFLKPHLQPSLQLHNPCKWLSRVFIEQDDDMLEAAKASLGIYLTLTRGCEATESLTQGKEMWDHHTHENGYNPHCIFLFFLKNIGFDSTVLLDFLISSETCFLEYFVRYLKLLQKDWDNFFTICNNFDATESKYDISICGCVPSLVQDQSSNQTIPHRLTAPHSHRDVCARHSWASDAPSEPLKAVMSKGAHTMCASSLSSPRASQSLVDYDSSDDSDVESTEQCLANSKQTSLHQQATKEIQDAAGTSRDKKEFSLEPPSRPLVLKEFDTAFSFDCEVAPNDVVSEVGIFYRIVKCFQELQDAICRLQKKNLFPYNPTALLKLLKYIEVISNKTMNTL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	KKVLLGATLENDSHD HHHHHCCCCCCCCCC	32.57	-
94	Phosphorylation	EVMLLQLTVIKVMTT HHHHHHHHHHHHHHH	13.76	-
105	Phosphorylation	VMTTRILSVKTEFHA HHHHHHHHCCCCCCC	21.13	24719451
113	Ubiquitination	VKTEFHAKEQYRDVI CCCCCCCHHHHHHHH	36.46	29967540
317	Methylation	KVGEDLCRGSVPALM HHCHHHHCCCCCCCC	47.95	18583743
407 (in isoform 3)	Ubiquitination	-	26.44	21906983
407	Ubiquitination	YSSASEVKVDLQRFM CCCHHHHHHHHHHHH	26.44	-
422	Ubiquitination	SELLTFLKPHLQPSL HHHHHHHHHHCCCCH	26.63	-
474	Phosphorylation	CEATESLTQGKEMWD CCCCHHHHCCCCHHH	44.55	-
578	Phosphorylation	QTIPHRLTAPHSHRD CCCCCCCCCCCCCCC	37.79	22210691
591	Phosphorylation	RDVCARHSWASDAPS CCHHHHCCCCCCCCC	20.84	25159151
598	Phosphorylation	SWASDAPSEPLKAVM CCCCCCCCHHHHHHH	54.27	-
606	Phosphorylation	EPLKAVMSKGAHTMC HHHHHHHCCCCCHHH	22.72	22210691
611	Phosphorylation	VMSKGAHTMCASSLS HHCCCCCHHHHHHCC	17.26	-
615	Phosphorylation	GAHTMCASSLSSPRA CCCHHHHHHCCCCCH	27.21	29978859
616	Phosphorylation	AHTMCASSLSSPRAS CCHHHHHHCCCCCHH	17.47	28450419
618	Phosphorylation	TMCASSLSSPRASQS HHHHHHCCCCCHHHC	40.00	28450419
619	Phosphorylation	MCASSLSSPRASQSL HHHHHCCCCCHHHCC	24.57	25159151
635	Phosphorylation	DYDSSDDSDVESTEQ CCCCCCCCCCCHHHH	48.85	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LINES_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LINES_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LINES_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of LINES_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 614340: Mental retardation, autosomal recessive 27 (MRT27)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.