REST_MOUSE - dbPTM
REST_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID REST_MOUSE
UniProt AC Q8VIG1
Protein Name RE1-silencing transcription factor
Gene Name Rest
Organism Mus musculus (Mouse).
Sequence Length 1082
Subcellular Localization Nucleus . Colocalizes with ZFP90 in the nucleus.
Protein Description Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression..
Protein Sequence MATQVMGQSSGGGSLFNNSANMGMALTNDMYDLHELSKAELAAPQLIMLANVALTGEASGSCCDYLVGEERQMAELMPVGDNHFSESEGEGLEESADLKGLENMELGSLELSAVEPQPVFEASAAPEIYSANKDPAPETPVAEDKCRSSKAKPFRCKPCQYEAESEEQFVHHIRIHSAKKFFVEESAEKQAKAWESGSSPAEEGEFSKGPIRCDRCGYNTNRYDHYMAHLKHHLRAGENERIYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCSKCNYFSDRKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKTKKREADLLNNAVSNEKMENEQTKTKGDVSGKKNEKPVKAVGKDASKEKKPGSSVSVVQVTTRTRKSAVAAETKAAEVKHTDGQTGNNPEKPCKAKKNKRKKDAEAHPSEEPVNEGPVTKKKKKSECKSKIGTNVPKGGGRAEERPGVKKQSASLKKGTKKTPPKTKTSKKGGKLAPKGMGQTEPSSGALAQVGVSPDPALIQAEVTGSGSSQTELPSPMDIAKSEPAQMEVSLTGPPPVEPAQMEPSPAKPPQVEAPTYPQPPQRGPAPPTGPAPPTGPAPPTEPAPPTGLAEMEPSPTEPSQKEPPPSMEPPCPEELPQAEPPPMEDCQKELPSPVEPAQIEVAQTAPTQVQEEPPPVSEPPRVKPTKRSSLRKDRAEKELSLLSEMARQEQVLMGVGLVPVRDSKLLKGNKSAQDPPAPPSPSPKGNSREETPKDQEMVSDGEGTIVFPLKKGGPEEAGESPAELAALKESARVSSSEQNSAMPEGGASHSKCQTGSSGLCDVDTEQKTDTVPMKDSAAEPVSPPTPTVDRDAGSPAVVASPPITLAENESQEIDEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPTPPEATSKNGKAGLAGKVTEGEFVCIFCDRSFRKEKDYSKHLNRHLVNVYFLEEAAEEQEEQEEREEQE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
85PhosphorylationPVGDNHFSESEGEGL
CCCCCCCCCCCCCCC
32.4427087446
87PhosphorylationGDNHFSESEGEGLEE
CCCCCCCCCCCCCHH
50.1027087446
196PhosphorylationKQAKAWESGSSPAEE
HHHHHHHCCCCCCCC
33.0230635358
198PhosphorylationAKAWESGSSPAEEGE
HHHHHCCCCCCCCCC
42.2930635358
199PhosphorylationKAWESGSSPAEEGEF
HHHHCCCCCCCCCCC
31.4930635358
207PhosphorylationPAEEGEFSKGPIRCD
CCCCCCCCCCCCCCC
32.1930635358
312PhosphorylationPYSSSQKTHLTRHMR
CCCCCCCHHHHHHHC
17.9322817900
320PhosphorylationHLTRHMRTHSGEKPF
HHHHHHCCCCCCCCE
16.9022817900
463AcetylationKKNEKPVKAVGKDAS
CCCCCCCEECCCCCC
45.9719861635
490AcetylationQVTTRTRKSAVAAET
EEEECCCHHHHHHCC
42.006565911
585AcetylationSLKKGTKKTPPKTKT
CCCCCCCCCCCCCCC
67.137385615
672PhosphorylationEPAQMEPSPAKPPQV
CCCCCCCCCCCCCCC
24.9622006019
760PhosphorylationDCQKELPSPVEPAQI
HHHHHCCCCCCHHHE
54.9525338131
839PhosphorylationKLLKGNKSAQDPPAP
HHCCCCCCCCCCCCC
34.8525619855
848PhosphorylationQDPPAPPSPSPKGNS
CCCCCCCCCCCCCCC
36.6327087446
850PhosphorylationPPAPPSPSPKGNSRE
CCCCCCCCCCCCCCC
43.5123684622
867PhosphorylationPKDQEMVSDGEGTIV
CCCHHHCCCCCCEEE
38.2926643407
872PhosphorylationMVSDGEGTIVFPLKK
HCCCCCCEEEEECCC
15.0722817900
888PhosphorylationGPEEAGESPAELAAL
CHHHCCCCHHHHHHH
28.6130635358
950PhosphorylationDSAAEPVSPPTPTVD
CCCCCCCCCCCCCCC
35.5625619855
953PhosphorylationAEPVSPPTPTVDRDA
CCCCCCCCCCCCCCC
34.6725619855
955PhosphorylationPVSPPTPTVDRDAGS
CCCCCCCCCCCCCCC
37.2025619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of REST_MOUSE !!

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of REST_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of REST_MOUSE !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SP3_MOUSESp3physical
17130167

Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of REST_MOUSE

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Related Literatures of Post-Translational Modification

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