UniProt ID | REST_MOUSE | |
---|---|---|
UniProt AC | Q8VIG1 | |
Protein Name | RE1-silencing transcription factor | |
Gene Name | Rest | |
Organism | Mus musculus (Mouse). | |
Sequence Length | 1082 | |
Subcellular Localization | Nucleus . Colocalizes with ZFP90 in the nucleus. | |
Protein Description | Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.. | |
Protein Sequence | MATQVMGQSSGGGSLFNNSANMGMALTNDMYDLHELSKAELAAPQLIMLANVALTGEASGSCCDYLVGEERQMAELMPVGDNHFSESEGEGLEESADLKGLENMELGSLELSAVEPQPVFEASAAPEIYSANKDPAPETPVAEDKCRSSKAKPFRCKPCQYEAESEEQFVHHIRIHSAKKFFVEESAEKQAKAWESGSSPAEEGEFSKGPIRCDRCGYNTNRYDHYMAHLKHHLRAGENERIYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCSKCNYFSDRKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKTKKREADLLNNAVSNEKMENEQTKTKGDVSGKKNEKPVKAVGKDASKEKKPGSSVSVVQVTTRTRKSAVAAETKAAEVKHTDGQTGNNPEKPCKAKKNKRKKDAEAHPSEEPVNEGPVTKKKKKSECKSKIGTNVPKGGGRAEERPGVKKQSASLKKGTKKTPPKTKTSKKGGKLAPKGMGQTEPSSGALAQVGVSPDPALIQAEVTGSGSSQTELPSPMDIAKSEPAQMEVSLTGPPPVEPAQMEPSPAKPPQVEAPTYPQPPQRGPAPPTGPAPPTGPAPPTEPAPPTGLAEMEPSPTEPSQKEPPPSMEPPCPEELPQAEPPPMEDCQKELPSPVEPAQIEVAQTAPTQVQEEPPPVSEPPRVKPTKRSSLRKDRAEKELSLLSEMARQEQVLMGVGLVPVRDSKLLKGNKSAQDPPAPPSPSPKGNSREETPKDQEMVSDGEGTIVFPLKKGGPEEAGESPAELAALKESARVSSSEQNSAMPEGGASHSKCQTGSSGLCDVDTEQKTDTVPMKDSAAEPVSPPTPTVDRDAGSPAVVASPPITLAENESQEIDEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPTPPEATSKNGKAGLAGKVTEGEFVCIFCDRSFRKEKDYSKHLNRHLVNVYFLEEAAEEQEEQEEREEQE | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
85 | Phosphorylation | PVGDNHFSESEGEGL CCCCCCCCCCCCCCC | 32.44 | 27087446 | |
87 | Phosphorylation | GDNHFSESEGEGLEE CCCCCCCCCCCCCHH | 50.10 | 27087446 | |
196 | Phosphorylation | KQAKAWESGSSPAEE HHHHHHHCCCCCCCC | 33.02 | 30635358 | |
198 | Phosphorylation | AKAWESGSSPAEEGE HHHHHCCCCCCCCCC | 42.29 | 30635358 | |
199 | Phosphorylation | KAWESGSSPAEEGEF HHHHCCCCCCCCCCC | 31.49 | 30635358 | |
207 | Phosphorylation | PAEEGEFSKGPIRCD CCCCCCCCCCCCCCC | 32.19 | 30635358 | |
312 | Phosphorylation | PYSSSQKTHLTRHMR CCCCCCCHHHHHHHC | 17.93 | 22817900 | |
320 | Phosphorylation | HLTRHMRTHSGEKPF HHHHHHCCCCCCCCE | 16.90 | 22817900 | |
463 | Acetylation | KKNEKPVKAVGKDAS CCCCCCCEECCCCCC | 45.97 | 19861635 | |
490 | Acetylation | QVTTRTRKSAVAAET EEEECCCHHHHHHCC | 42.00 | 6565911 | |
585 | Acetylation | SLKKGTKKTPPKTKT CCCCCCCCCCCCCCC | 67.13 | 7385615 | |
672 | Phosphorylation | EPAQMEPSPAKPPQV CCCCCCCCCCCCCCC | 24.96 | 22006019 | |
760 | Phosphorylation | DCQKELPSPVEPAQI HHHHHCCCCCCHHHE | 54.95 | 25338131 | |
839 | Phosphorylation | KLLKGNKSAQDPPAP HHCCCCCCCCCCCCC | 34.85 | 25619855 | |
848 | Phosphorylation | QDPPAPPSPSPKGNS CCCCCCCCCCCCCCC | 36.63 | 27087446 | |
850 | Phosphorylation | PPAPPSPSPKGNSRE CCCCCCCCCCCCCCC | 43.51 | 23684622 | |
867 | Phosphorylation | PKDQEMVSDGEGTIV CCCHHHCCCCCCEEE | 38.29 | 26643407 | |
872 | Phosphorylation | MVSDGEGTIVFPLKK HCCCCCCEEEEECCC | 15.07 | 22817900 | |
888 | Phosphorylation | GPEEAGESPAELAAL CHHHCCCCHHHHHHH | 28.61 | 30635358 | |
950 | Phosphorylation | DSAAEPVSPPTPTVD CCCCCCCCCCCCCCC | 35.56 | 25619855 | |
953 | Phosphorylation | AEPVSPPTPTVDRDA CCCCCCCCCCCCCCC | 34.67 | 25619855 | |
955 | Phosphorylation | PVSPPTPTVDRDAGS CCCCCCCCCCCCCCC | 37.20 | 25619855 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of REST_MOUSE !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of REST_MOUSE !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of REST_MOUSE !! |
Kegg Drug | ||||||
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DrugBank | ||||||
There are no disease associations of PTM sites. |
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