TFDP1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TFDP1_MOUSE
• UniProt AC: Q08639
• Protein Name: Transcription factor Dp-1
• Gene Name: Tfdp1
• Organism: Mus musculus (Mouse).
• Sequence Length: 410
• Subcellular Localization: Nucleus . Cytoplasm . Shuttles between the cytoplasm and nucleus and translocates into the nuclear compartment upon heterodimerization with E2F1.
• Protein Description: Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters. [PubMed: 20176812]
• Protein Sequence: MAKDASLIEANGELKVFIDQNLSPGKGVVSLVAVHPSTVNTLGKQLLPKTFGQSNVNITQQVVIGTPQRPAASNTIVVGSPHTPNTHFVSQNQTSDSSPWSAGKRNRKGEKNGKGLRHFSMKVCEKVQRKGTTSYNEVADELVAEFSAADNHILPNESAYDQKNIRRRVYDALNVLMAMNIISKEKKEIKWIGLPTNSAQECQNLEVERQRRLERIKQKQSQLQELILQQIAFKNLVQRNRQAEQQARRPPPPNSVIHLPFIIVNTSRKTVIDCSISNDKFEYLFNFDNTFEIHDDIEVLKRMGMACGLESGNCSAEDLKVARSLVPKALEPYVTEMAQGSIGGVFVTTTGSTSNGTRLSASDLSNGADGMLATSSNGSQYSGSRVETPVSYVGEDDDDDDDFNENDEED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MAKDASLIEA -----CCCCHHHEEC	53.15	23806337
6	Phosphorylation	--MAKDASLIEANGE --CCCCHHHEECCCE	39.76	28066266
23	Phosphorylation	VFIDQNLSPGKGVVS EEEECCCCCCCCEEE	38.87	27087446
30	Phosphorylation	SPGKGVVSLVAVHPS CCCCCEEEEEEECHH	18.08	25159016
37	Phosphorylation	SLVAVHPSTVNTLGK EEEEECHHHHHHCHH	30.06	25777480
38	Phosphorylation	LVAVHPSTVNTLGKQ EEEECHHHHHHCHHH	23.40	25777480
41	Phosphorylation	VHPSTVNTLGKQLLP ECHHHHHHCHHHHCC	32.33	25777480
170	Phosphorylation	KNIRRRVYDALNVLM HHHHHHHHHHHHHHH	8.16	25293948
183	Phosphorylation	LMAMNIISKEKKEIK HHHHHHHCCCCCCCE	30.85	22871156
365	Phosphorylation	RLSASDLSNGADGML EEEHHHCCCCCCCEE	37.90	22871156
376	Phosphorylation	DGMLATSSNGSQYSG CCEEEECCCCCCCCC	40.64	22871156
382	Phosphorylation	SSNGSQYSGSRVETP CCCCCCCCCCCEECC	23.74	22871156
388	Phosphorylation	YSGSRVETPVSYVGE CCCCCEECCCEECCC	26.57	22006019
391	Phosphorylation	SRVETPVSYVGEDDD CCEECCCEECCCCCC	18.46	26370283

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TFDP1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TFDP1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TFDP1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
E2F6_HUMAN	E2F6	physical	15536069
SRTD2_HUMAN	SERTAD2	physical	11331592
SRTD1_MOUSE	Sertad1	physical	11331592

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.