LIN54_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LIN54_MOUSE
• UniProt AC: Q571G4
• Protein Name: Protein lin-54 homolog
• Gene Name: Lin54
• Organism: Mus musculus (Mouse).
• Sequence Length: 749
• Subcellular Localization: Nucleus.
• Protein Description: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context. In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes. In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation. In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner. Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA..
• Protein Sequence: MEVVPAEVNSLLPDDIMDTAITLVDEDSIEAVIVSSPIPMETELEEIVNINSTGDSTATPISTEPITVYSNHTNQVAVNTTVSKADSNTTVKPAFPSGLQKLGAQTPVTISANQIILNKVSQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQLPQAQKVTAQAQPGDAKLPPQQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSVLQTQQLKTVQIAKKPRTPTSGPVITKLIFAKPINSKAVTGQTTQASPPVVTGRVLSQSTPGTPSKTITISESGVIGSTLNSTTQTPNKIAISPLKSPNKTVKSAVQTITVGGMSTSQFKTIIPLATAPNVQQIQVPGSKFHYVRLVTATTASSSAQPVSQSPSVNTQPLQQAKPVVVNTTPVRMSVPFVQAQAVKQVVPKPINSTSQIVTTSQPQQRLIMPATPLPQIQPNLTNLPPGTVLAPAPGTGNVGYAVLPAQYVTQLQQSSYVSIASNSNFTGTSGIQTQARLPFNGIIPSESTSRPRKPCNCTKSLCLKLYCDCFANGEFCNNCNCTNCYNNLEHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCNCKRSGCLKNYCECYEAKIMCSSICKCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSSQISDLLTRPTPALNSAGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAERMILEEFGRCLMSVINSAGKAKSDPCAMHC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
235	Phosphorylation	QIAKKPRTPTSGPVI EECCCCCCCCCCCCE	39.17	28066266
237	Phosphorylation	AKKPRTPTSGPVITK CCCCCCCCCCCCEEE	45.78	28066266
238	Phosphorylation	KKPRTPTSGPVITKL CCCCCCCCCCCEEEE	42.16	28066266
244	Acetylation	TSGPVITKLIFAKPI CCCCCEEEEEEEEEC	28.58	-
249	Acetylation	ITKLIFAKPINSKAV EEEEEEEEECCCCCC	35.36	23806337
257	Phosphorylation	PINSKAVTGQTTQAS ECCCCCCCCCCCCCC	28.56	25619855
260	Phosphorylation	SKAVTGQTTQASPPV CCCCCCCCCCCCCCE	23.40	25619855
261	Phosphorylation	KAVTGQTTQASPPVV CCCCCCCCCCCCCEE	17.78	25619855
264	Phosphorylation	TGQTTQASPPVVTGR CCCCCCCCCCEEEEE	21.66	22942356
269	Phosphorylation	QASPPVVTGRVLSQS CCCCCEEEEEEECCC	21.36	25619855
274	Phosphorylation	VVTGRVLSQSTPGTP EEEEEEECCCCCCCC	21.16	28066266
276	Phosphorylation	TGRVLSQSTPGTPSK EEEEECCCCCCCCCC	32.94	26643407
277	Phosphorylation	GRVLSQSTPGTPSKT EEEECCCCCCCCCCE	20.35	25266776
280	Phosphorylation	LSQSTPGTPSKTITI ECCCCCCCCCCEEEE	26.12	25266776
282	Phosphorylation	QSTPGTPSKTITISE CCCCCCCCCEEEEEC	42.12	26643407
310	Phosphorylation	TPNKIAISPLKSPNK CCCEEEECCCCCCCC	18.37	26824392
314	Phosphorylation	IAISPLKSPNKTVKS EEECCCCCCCCCHHH	41.19	26824392
318	Phosphorylation	PLKSPNKTVKSAVQT CCCCCCCCHHHHCEE	39.54	21183079
397	Phosphorylation	AKPVVVNTTPVRMSV CCCEEEECCCCCCCC	22.37	28066266
398	Phosphorylation	KPVVVNTTPVRMSVP CCEEEECCCCCCCCC	18.00	28066266
435	Methylation	TTSQPQQRLIMPATP ECCCCCCEEECCCCC	22.42	-
457	Phosphorylation	LTNLPPGTVLAPAPG CCCCCCCCEEECCCC	20.37	-
635	Phosphorylation	GCKNFEESPERKTLM CCCCCCCCCCHHHHH	25.51	26824392

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LIN54_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LIN54_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LIN54_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LMBL2_HUMAN	L3MBTL2	physical	20360068
LIN37_HUMAN	LIN37	physical	20360068
MYBB_HUMAN	MYBL2	physical	20360068
LIN9_HUMAN	LIN9	physical	20360068
MYBA_HUMAN	MYBL1	physical	20360068
LIN54_HUMAN	LIN54	physical	20360068
RBBP4_HUMAN	RBBP4	physical	20360068
LIN52_HUMAN	LIN52	physical	20360068

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.