MOV10_MOUSE - dbPTM
MOV10_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MOV10_MOUSE
UniProt AC P23249
Protein Name Putative helicase MOV-10
Gene Name Mov10
Organism Mus musculus (Mouse).
Sequence Length 1004
Subcellular Localization Cytoplasm, P-body .
Protein Description Probable RNA helicase. Required for miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (By similarity)..
Protein Sequence MPSKFSCRKLRETGQRFESFLAERGLDLETDRERLRTIYNHDFKPSYGTPAPGFSSMLYGMKIANLAFVTKTRVRFFKLDRWADVQLPEKRRIKPGSNISKQHRSLLARIFHDRAEYLHGKHGVDVEVQGPHEARDGQLLIHLDLNRKEVLTLRLRNGGSKPVTLTHLFPLCWTPQFVFYHGEQDLPCPLGPGESYELHIYCKTSIVGYFPATVLWELLGPGESGAEGAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNSVLTNRIEEGERPDRAKGYELELSLALGTYYPPILLRQLLPTLLQGPSIFTAPKEVAEIKAQLETTLKSRNYEVKLRLLLHLEELQMEHDIRHYDLDSVPMTWDPVDQNPRLLTLEVPGVAESRPSVLRGDHLFALLSSETQQDDPVTYKGFVHKVELDRVKLSFSTSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPMLFPVASRGVSLLPSDVKFKLYDRSLESNPEQLQAMKHIVRGTTRPAPYIIFGPPGTGKTVTLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRLRVHLPSSIYRLLAPSRDIRMVPEDIKTCCNWDAKKGEYVYPAKKHLQQYRVLITTLITASRLVSAQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKHGLGYSLLERLLAYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQACADVVDRERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLAPSSKKGKARLSPRNVGVISPYRKQVEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQSFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKENGGYTGCPFPAKLDLQQGQDLLQGLSKLSPSTSGPRRHQNLPQEREGEGGLPLQVEPEWRNEL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
19PhosphorylationETGQRFESFLAERGL
HHHHHHHHHHHHCCC		23.8929514104
90UbiquitinationADVQLPEKRRIKPGS
CCCCCCCCCCCCCCC		45.07-
97PhosphorylationKRRIKPGSNISKQHR
CCCCCCCCCHHHHHH		39.2529176673
100PhosphorylationIKPGSNISKQHRSLL
CCCCCCHHHHHHHHH		30.4329176673
101MethylationKPGSNISKQHRSLLA
CCCCCHHHHHHHHHH		46.45-
101UbiquitinationKPGSNISKQHRSLLA
CCCCCHHHHHHHHHH		46.45-
148AcetylationIHLDLNRKEVLTLRL
EEEECCCCEEEEEEE		51.61-
253PhosphorylationLAAQLKPTTPFKRPP
HHHHCCCCCCCCCCC		45.5826643407
254PhosphorylationAAQLKPTTPFKRPPR
HHHCCCCCCCCCCCC		34.9426643407
266PhosphorylationPPRLTRNSVLTNRIE
CCCCCCCHHHCCCCC		18.4029514104
282UbiquitinationGERPDRAKGYELELS
CCCCCCCCCCEEEHH		64.02-
319UbiquitinationPSIFTAPKEVAEIKA
CCCCCCCHHHHHHHH		63.46-
325UbiquitinationPKEVAEIKAQLETTL
CHHHHHHHHHHHHHH		22.91-
333UbiquitinationAQLETTLKSRNYEVK
HHHHHHHHHCCHHHH		45.32-
433PhosphorylationVKLSFSTSLLSRFVD
EEEEECHHHHHHHCC		26.56-
487PhosphorylationRGVSLLPSDVKFKLY
CCCCCCCCCCEEEEC		55.8129514104
490MalonylationSLLPSDVKFKLYDRS
CCCCCCCEEEECCCC		41.6026320211
490UbiquitinationSLLPSDVKFKLYDRS
CCCCCCCEEEECCCC		41.60-
509UbiquitinationPEQLQAMKHIVRGTT
HHHHHHHHHHHHCCC		32.94-
583PhosphorylationIYRLLAPSRDIRMVP
HHHHHCCCCCCCCCC		36.6619854140
602UbiquitinationTCCNWDAKKGEYVYP
HHCCCCCCCCCEEEE		59.86-
696UbiquitinationLRSPLALKHGLGYSL
CCCHHHHHCCCCHHH		29.98-
715UbiquitinationLAYNSLYKKGPNGYD
HHHHHHHHCCCCCCC		57.45-
728UbiquitinationYDPQFITKLLRNYRS
CCHHHHHHHHHHCCC		40.48-
847UbiquitinationKIRYCITKLDRELRG
HHHHHHHHHHHHHCC		28.60-
859AcetylationLRGLDDIKDLKVGSV
HCCCCCCCCCCCCCH		65.0966700841
859UbiquitinationLRGLDDIKDLKVGSV
HCCCCCCCCCCCCCH		65.09-
967PhosphorylationQDLLQGLSKLSPSTS
HHHHHHHHHCCCCCC		38.0722942356
968UbiquitinationDLLQGLSKLSPSTSG
HHHHHHHHCCCCCCC		59.01-
970PhosphorylationLQGLSKLSPSTSGPR
HHHHHHCCCCCCCCC		22.1227087446
972PhosphorylationGLSKLSPSTSGPRRH
HHHHCCCCCCCCCCC		31.6522942356
973PhosphorylationLSKLSPSTSGPRRHQ
HHHCCCCCCCCCCCC		40.8822942356
974PhosphorylationSKLSPSTSGPRRHQN
HHCCCCCCCCCCCCC		51.6525159016
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MOV10_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MOV10_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MOV10_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MOV10_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of MOV10_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-970, AND MASSSPECTROMETRY.

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