ZN609_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZN609_MOUSE
• UniProt AC: Q8BZ47
• Protein Name: Zinc finger protein 609
• Gene Name: Znf609
• Organism: Mus musculus (Mouse).
• Sequence Length: 1413
• Subcellular Localization: Nucleus .
• Protein Description: Transcription factor, which activates RAG1, and possibly RAG2, transcription. Through the regulation of RAG1/2 expression, may regulate thymocyte maturation. [PubMed: 28344082 Along with NIPBL and the multiprotein complex Integrator, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others]
• Protein Sequence: MSLSSGACGGKGVDANPVETYDSGDEWDIGVGNLIIDLDADLEKDQQKLEMSGSKEVGIPAPNAVATLPDNIKFVTPVPGPQGKEGKSKSKRSKSGKDASKPTPGTSLFSPSEGAASKKEVQGRAGDGASAGGLVAAVAPKGSEKAAKASRSVAGSKKEKENSSSKGKKERSEGVGTCSEKDPGVLQPVPLGGRGSQYDGSAGMDTGTVEPLGSIAIEPGAALNPLGTKPEPEEGENECRPLKKVKSEKMESPVSTPAVLPLHLLVPVVNNDISSPCEQIMVRTRSVGVNTCDVALATEPECLGPCEPGTSVNLEGIVWQETEDGMLVVNVTWRNKTYVGTLLDCTRHDWAPPRFCDSPTSDLEMRNGRGRGKRMRPSSNTPVSEAAAASDSKGTSSSSKTRAGANSKGRRGSQNSSEHRPPASSTSEDVKASPSSANKRKSKPLSDMELNSSSEDSKGSKRVRTNSMGSATGPLPGTKVEPTLVDRNCPSPVLIDCPHPNCNKKYKHINGLKYHQAHAHTDDDSKPEADGDSEYGEEPALHADLSCNGAPVPQKGSLSPARSATPKVRLVEPHSPSPSSKFSTKGLCKKKLSGEGDTDPGALSNDGSDDGPSVMDETSNDAFDSLERKCMEKEKCKKPSSLKSEKIPSKSLKSARPIAPAIPPQQIYTFQTATFTAASPGSSSGLTTTVVQAMPNSPQLKPIQPKPTVMGEPFTVNPALTPAKDKKKKDKKKKDSSKELESPLTPGKVCRAEEGKSPFRDAAGDGIKVESLLNGSSESHQSRLASIKAEADKIYSFTDNAPSPSIGGSSRLDSTTPTQPLTPLHVVTQNGAEASSVKTNSPAYSDISDAGEDGEGKVDSAKSKDPEQLVKEGAKKTLFPPQPQSKDSPYYQGFESYYSPGYAQSSPGTLTSSSQAGMEGQPLKTKKDEEPESVEGKVKNDVCEEKKPELSNSSQQPSVIQQRPNMYMQSLYYNQYAYVPPYGYSDQSYHSHLLSTNTAYRQQYEEQQKRQSLEQQQQQQRGLDKKTEMGLKEREASLKEEWKQKPSIPPTLTKAPSLTDLVKSGPGKAKEPGTDPAKSVIIPKLDDSSKLPSQPPEGLKGKLGEASHLGKEASEAKTGTECGRQAEVDPILWYRQETESRMWTYVYPAKYSDIKSEDDRWKEERDRKLKEDRSRSKDSVPKEDGKESTSSDCKLPPSEESRLGSKEPRPSVHVPVSSPLTQHQSYIPYMHGYSYSQSYDPNHPSYRGMPAVMMQNYPGSYLPSSYSFSPYGSKVSGGEDADKARASPSVSCKASSESKALDILQQHASHYKSKSPTISDKNSQERDRGGCGVVGGGGSCGSVAGAGGTDRSADRPRTSPSQRLMSTHHHHHHLGYSLLPAQYNLPYAAGLSSTAIVASQQGSTPSLYPPPRR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
100	Phosphorylation	SKSGKDASKPTPGTS CCCCCCCCCCCCCCC	49.67	28066266
103	Phosphorylation	GKDASKPTPGTSLFS CCCCCCCCCCCCCCC	37.78	28066266
106	Phosphorylation	ASKPTPGTSLFSPSE CCCCCCCCCCCCCCC	24.38	28066266
107	Phosphorylation	SKPTPGTSLFSPSEG CCCCCCCCCCCCCCC	33.07	28066266
110	Phosphorylation	TPGTSLFSPSEGAAS CCCCCCCCCCCCCCC	32.58	28066266
112	Phosphorylation	GTSLFSPSEGAASKK CCCCCCCCCCCCCCC	47.68	28066266
117	Phosphorylation	SPSEGAASKKEVQGR CCCCCCCCCCCCCCC	43.67	28066266
130	Phosphorylation	GRAGDGASAGGLVAA CCCCCCCCCCCCEEE	32.73	25159016
252	Phosphorylation	VKSEKMESPVSTPAV HCCCCCCCCCCCCCE	27.40	26239621
255	Phosphorylation	EKMESPVSTPAVLPL CCCCCCCCCCCEEEH	31.86	23649490
256	Phosphorylation	KMESPVSTPAVLPLH CCCCCCCCCCEEEHH	18.59	26643407
358	Phosphorylation	APPRFCDSPTSDLEM CCCCCCCCCCCCCCC	31.12	25521595
360	Phosphorylation	PRFCDSPTSDLEMRN CCCCCCCCCCCCCCC	38.53	21082442
361	Phosphorylation	RFCDSPTSDLEMRNG CCCCCCCCCCCCCCC	43.51	21082442
378	Phosphorylation	RGKRMRPSSNTPVSE CCCCCCCCCCCCHHH	26.34	26643407
379	Phosphorylation	GKRMRPSSNTPVSEA CCCCCCCCCCCHHHH	47.62	26643407
381	Phosphorylation	RMRPSSNTPVSEAAA CCCCCCCCCHHHHHH	27.32	26643407
390	Phosphorylation	VSEAAAASDSKGTSS HHHHHHHCCCCCCCC	37.38	29514104
413	Phosphorylation	NSKGRRGSQNSSEHR CCCCCCCCCCCCCCC	25.11	26824392
416	Phosphorylation	GRRGSQNSSEHRPPA CCCCCCCCCCCCCCC	29.48	29472430
417	Phosphorylation	RRGSQNSSEHRPPAS CCCCCCCCCCCCCCC	45.00	29472430
424	Phosphorylation	SEHRPPASSTSEDVK CCCCCCCCCCCCHHC	39.66	25777480
425	Phosphorylation	EHRPPASSTSEDVKA CCCCCCCCCCCHHCC	37.75	25777480
426	Phosphorylation	HRPPASSTSEDVKAS CCCCCCCCCCHHCCC	33.37	25777480
427	Phosphorylation	RPPASSTSEDVKASP CCCCCCCCCHHCCCC	33.47	29472430
433	Phosphorylation	TSEDVKASPSSANKR CCCHHCCCCCCCCCC	21.43	-
435	Phosphorylation	EDVKASPSSANKRKS CHHCCCCCCCCCCCC	39.32	-
436	Phosphorylation	DVKASPSSANKRKSK HHCCCCCCCCCCCCC	38.96	-
442	Phosphorylation	SSANKRKSKPLSDME CCCCCCCCCCCCCCC	43.47	25619855
446	Phosphorylation	KRKSKPLSDMELNSS CCCCCCCCCCCCCCC	43.36	25619855
452	Phosphorylation	LSDMELNSSSEDSKG CCCCCCCCCCCCCCC	48.11	25619855
453	Phosphorylation	SDMELNSSSEDSKGS CCCCCCCCCCCCCCC	36.35	25619855
454	Phosphorylation	DMELNSSSEDSKGSK CCCCCCCCCCCCCCC	45.29	25619855
457	Phosphorylation	LNSSSEDSKGSKRVR CCCCCCCCCCCCCCC	34.56	25619855
460	Phosphorylation	SSEDSKGSKRVRTNS CCCCCCCCCCCCCCC	22.48	25619855
465	Phosphorylation	KGSKRVRTNSMGSAT CCCCCCCCCCCCCCC	28.87	23527152
467	Phosphorylation	SKRVRTNSMGSATGP CCCCCCCCCCCCCCC	24.73	25521595
470	Phosphorylation	VRTNSMGSATGPLPG CCCCCCCCCCCCCCC	17.64	28833060
472	Phosphorylation	TNSMGSATGPLPGTK CCCCCCCCCCCCCCC	40.82	28833060
478	Phosphorylation	ATGPLPGTKVEPTLV CCCCCCCCCCCCCEE	29.94	28833060
483	Phosphorylation	PGTKVEPTLVDRNCP CCCCCCCCEECCCCC	26.38	26060331
491	Phosphorylation	LVDRNCPSPVLIDCP EECCCCCCCEEEECC	29.82	27087446
525	Phosphorylation	HAHTDDDSKPEADGD ECCCCCCCCCCCCCC	58.04	21183079
533	Phosphorylation	KPEADGDSEYGEEPA CCCCCCCCCCCCCCC	37.94	21183079
557	Phosphorylation	APVPQKGSLSPARSA CCCCCCCCCCCCCCC	32.48	23984901
559	Phosphorylation	VPQKGSLSPARSATP CCCCCCCCCCCCCCC	20.43	27149854
563	Phosphorylation	GSLSPARSATPKVRL CCCCCCCCCCCCEEE	38.30	23984901
565	Phosphorylation	LSPARSATPKVRLVE CCCCCCCCCCEEEEC	25.53	26745281
575	Phosphorylation	VRLVEPHSPSPSSKF EEEECCCCCCCCCCC	37.48	27087446
577	Phosphorylation	LVEPHSPSPSSKFST EECCCCCCCCCCCCC	40.19	27087446
579	Phosphorylation	EPHSPSPSSKFSTKG CCCCCCCCCCCCCCC	50.96	21082442
580	Phosphorylation	PHSPSPSSKFSTKGL CCCCCCCCCCCCCCC	40.90	21082442
604	Phosphorylation	DTDPGALSNDGSDDG CCCCCCCCCCCCCCC	32.13	19854140
608	Phosphorylation	GALSNDGSDDGPSVM CCCCCCCCCCCCCCC	35.08	19854140
618	Phosphorylation	GPSVMDETSNDAFDS CCCCCCCCCCHHHHH	28.68	19854140
619	Phosphorylation	PSVMDETSNDAFDSL CCCCCCCCCHHHHHH	30.57	25338131
644	Phosphorylation	KKPSSLKSEKIPSKS CCCCCCCCCCCCCCC	49.79	25619855
649	Phosphorylation	LKSEKIPSKSLKSAR CCCCCCCCCCCCCCC	38.05	25619855
721	Phosphorylation	FTVNPALTPAKDKKK CCCCCCCCCCCCCCC	24.25	28066266
742	Phosphorylation	DSSKELESPLTPGKV CCHHHCCCCCCCCCC	37.52	28833060
745	Phosphorylation	KELESPLTPGKVCRA HHCCCCCCCCCCEEC	33.12	25521595
757	Phosphorylation	CRAEEGKSPFRDAAG EECCCCCCCCCCCCC	39.88	26824392
779	Phosphorylation	LLNGSSESHQSRLAS HHCCCCHHHHHHHHH	28.86	28059163
782	Phosphorylation	GSSESHQSRLASIKA CCCHHHHHHHHHHHH	24.68	28059163
803	Phosphorylation	SFTDNAPSPSIGGSS EECCCCCCCCCCCCC	28.95	25521595
805	Phosphorylation	TDNAPSPSIGGSSRL CCCCCCCCCCCCCCC	37.90	25619855
809	Phosphorylation	PSPSIGGSSRLDSTT CCCCCCCCCCCCCCC	13.68	25619855
810	Phosphorylation	SPSIGGSSRLDSTTP CCCCCCCCCCCCCCC	39.89	25619855
814	Phosphorylation	GGSSRLDSTTPTQPL CCCCCCCCCCCCCCC	38.48	26643407
815	Phosphorylation	GSSRLDSTTPTQPLT CCCCCCCCCCCCCCC	36.14	26643407
816	Phosphorylation	SSRLDSTTPTQPLTP CCCCCCCCCCCCCCC	28.43	26643407
818	Phosphorylation	RLDSTTPTQPLTPLH CCCCCCCCCCCCCEE	40.50	26643407
822	Phosphorylation	TTPTQPLTPLHVVTQ CCCCCCCCCEEEEEC	30.41	26643407
828	Phosphorylation	LTPLHVVTQNGAEAS CCCEEEEECCCCCCC	18.41	26643407
839	Phosphorylation	AEASSVKTNSPAYSD CCCCCCCCCCCCCCC	38.48	26745281
841	Phosphorylation	ASSVKTNSPAYSDIS CCCCCCCCCCCCCCC	19.01	23684622
844	Phosphorylation	VKTNSPAYSDISDAG CCCCCCCCCCCCCCC	15.40	26643407
845	Phosphorylation	KTNSPAYSDISDAGE CCCCCCCCCCCCCCC	30.49	23684622
848	Phosphorylation	SPAYSDISDAGEDGE CCCCCCCCCCCCCCC	26.80	23684622
860	Phosphorylation	DGEGKVDSAKSKDPE CCCCCCCCCCCCCHH	40.35	23984901
871	Acetylation	KDPEQLVKEGAKKTL CCHHHHHHHCCCCCC	60.05	19855097
905	Phosphorylation	YSPGYAQSSPGTLTS CCCCCCCCCCCCCCC	30.26	26643407
906	Phosphorylation	SPGYAQSSPGTLTSS CCCCCCCCCCCCCCC	18.44	26643407
909	Phosphorylation	YAQSSPGTLTSSSQA CCCCCCCCCCCCCCC	30.19	26643407
911	Phosphorylation	QSSPGTLTSSSQAGM CCCCCCCCCCCCCCC	26.80	26643407
912	Phosphorylation	SSPGTLTSSSQAGME CCCCCCCCCCCCCCC	30.98	26643407
913	Phosphorylation	SPGTLTSSSQAGMEG CCCCCCCCCCCCCCC	22.64	26643407
914	Phosphorylation	PGTLTSSSQAGMEGQ CCCCCCCCCCCCCCC	24.66	26643407
1027	Phosphorylation	QRGLDKKTEMGLKER HHCCHHHHHHHHHHH	36.62	25619855
1037	Phosphorylation	GLKEREASLKEEWKQ HHHHHHHHHHHHHHC	34.91	25619855
1057	Phosphorylation	PTLTKAPSLTDLVKS CCCCCCCCHHHHHHC	49.08	25521595
1059	Phosphorylation	LTKAPSLTDLVKSGP CCCCCCHHHHHHCCC	31.46	28833060
1177	Acetylation	KEDRSRSKDSVPKED HHHHHCCCCCCCCCC	53.57	-
1287	Phosphorylation	DADKARASPSVSCKA CHHHHHCCCCCCCCC	16.50	30352176
1289	Phosphorylation	DKARASPSVSCKASS HHHHCCCCCCCCCCC	24.94	29472430
1291	Phosphorylation	ARASPSVSCKASSES HHCCCCCCCCCCCHH	17.78	29472430
1311	Phosphorylation	LQQHASHYKSKSPTI HHHHHHHHCCCCCCC	17.92	21454597
1313	Phosphorylation	QHASHYKSKSPTISD HHHHHHCCCCCCCCC	31.06	25266776
1315	Phosphorylation	ASHYKSKSPTISDKN HHHHCCCCCCCCCCC	34.07	26824392
1317	Phosphorylation	HYKSKSPTISDKNSQ HHCCCCCCCCCCCCC	39.96	28066266
1319	Phosphorylation	KSKSPTISDKNSQER CCCCCCCCCCCCCCC	45.04	28066266
1352	Phosphorylation	GAGGTDRSADRPRTS CCCCCCCCCCCCCCC	37.01	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZN609_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZN609_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZN609_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ZN609_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-575 AND SER-577, ANDMASS SPECTROMETRY.
PubMed: 17242355