G3BP2_MOUSE - dbPTM
G3BP2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID G3BP2_MOUSE
UniProt AC P97379
Protein Name Ras GTPase-activating protein-binding protein 2
Gene Name G3bp2
Organism Mus musculus (Mouse).
Sequence Length 482
Subcellular Localization
Protein Description Probable scaffold protein that may be involved in mRNA transport..
Protein Sequence MVMEKPSPLLVGREFVRQYYTLLNKAPEYLHRFYGRNSSYVHGGVDASGKPQEAVYGQNDIHHKVLSLNFSECHTKIRHVDAHATLSDGVVVQVMGLLSNSGQPERKFMQTFVLAPEGSVPNKFYVHNDMFRYEDEVFGDSEPELDEESEDEVEEEQEDRQPSPEPVQENANSAYYDAHPVTNGIEEPLEESSHEPEPEPESETKTEELKPQVEEKHLEELEEKSATPPPAEPASLPQEPPKAFSWASVTSKNLPPSGTVSSSGIPPHVKAPVSQPRVDAKPEVQSQPPRVREQRPRERPGFPPRGPRPGRGDMEQNDSDNRRIIRYPDSHQLFVGNLPHDIDENELKEFFMSFGNVVELRINTKGVGGKLPNFGFVVFDDSEPVQRILIAKPIMFRGEVRLNVEEKKTRAARERETRGGGDDRRDIRRNDRGPGGPRGIVGGGMMRDRDGRGPPPRGGMTQKLGSGRGTGQMEGRFTGQRR
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5Ubiquitination---MVMEKPSPLLVG
---CCCCCCCCCEEC		32.47-
7Phosphorylation-MVMEKPSPLLVGRE
-CCCCCCCCCEECHH		38.9730482847
25UbiquitinationQYYTLLNKAPEYLHR
HHHHHHHHCHHHHHH		66.35-
38PhosphorylationHRFYGRNSSYVHGGV
HHHHCCCCCCCCCCC		22.9925367039
39PhosphorylationRFYGRNSSYVHGGVD
HHHCCCCCCCCCCCC		34.4225367039
40PhosphorylationFYGRNSSYVHGGVDA
HHCCCCCCCCCCCCC		9.0425367039
48PhosphorylationVHGGVDASGKPQEAV
CCCCCCCCCCCCCCC		42.7725367039
56PhosphorylationGKPQEAVYGQNDIHH
CCCCCCCCCCCCHHH		21.7518563927
73S-nitrosocysteineLSLNFSECHTKIRHV
EEECHHHHCCEEEEE		4.84-
73S-nitrosylationLSLNFSECHTKIRHV
EEECHHHHCCEEEEE		4.8420925432
73S-palmitoylationLSLNFSECHTKIRHV
EEECHHHHCCEEEEE		4.8426165157
107AcetylationNSGQPERKFMQTFVL
CCCCCCHHEEEEEEE		43.4522826441
107UbiquitinationNSGQPERKFMQTFVL
CCCCCCHHEEEEEEE		43.45-
133PhosphorylationVHNDMFRYEDEVFGD
EECCCEECCCCCCCC		19.2329550500
141PhosphorylationEDEVFGDSEPELDEE
CCCCCCCCCCCCCCC		56.2725521595
149PhosphorylationEPELDEESEDEVEEE
CCCCCCCCHHHHHHH		48.5825521595
163PhosphorylationEQEDRQPSPEPVQEN
HHHHCCCCCCCCHHC		33.2925521595
206PhosphorylationEPESETKTEELKPQV
CCCCCCCHHHHHHHH		41.9528973931
225PhosphorylationLEELEEKSATPPPAE
HHHHHHHCCCCCCCC		40.4327087446
225 (in isoform 2)Phosphorylation-40.4325521595
227PhosphorylationELEEKSATPPPAEPA
HHHHHCCCCCCCCCC		43.3427087446
227 (in isoform 2)Phosphorylation-43.3425521595
235 (in isoform 2)Phosphorylation-51.8326239621
235PhosphorylationPPPAEPASLPQEPPK
CCCCCCCCCCCCCCC		51.8325521595
235O-linked_GlycosylationPPPAEPASLPQEPPK
CCCCCCCCCCCCCCC		51.8322517741
245PhosphorylationQEPPKAFSWASVTSK
CCCCCCCCCEECCCC		26.9623140645
250PhosphorylationAFSWASVTSKNLPPS
CCCCEECCCCCCCCC		31.3320469934
251PhosphorylationFSWASVTSKNLPPSG
CCCEECCCCCCCCCC		19.8620469934
281UbiquitinationSQPRVDAKPEVQSQP
CCCCCCCCCCHHCCC		36.93-
281MalonylationSQPRVDAKPEVQSQP
CCCCCCCCCCHHCCC		36.9326320211
327PhosphorylationDNRRIIRYPDSHQLF
CCCEEEECCCCCCEE		10.8629899451
330PhosphorylationRIIRYPDSHQLFVGN
EEEECCCCCCEEECC		14.5029899451
370UbiquitinationNTKGVGGKLPNFGFV
ECCCCCCCCCCCEEE		55.64-
392SuccinylationVQRILIAKPIMFRGE
HHEEEEEECEEECCE		28.25-
392AcetylationVQRILIAKPIMFRGE
HHEEEEEECEEECCE		28.2523806337
392MalonylationVQRILIAKPIMFRGE
HHEEEEEECEEECCE		28.2532601280
392SuccinylationVQRILIAKPIMFRGE
HHEEEEEECEEECCE		28.2523806337
457MethylationDGRGPPPRGGMTQKL
CCCCCCCCCCCEEEC		61.13-
457DimethylationDGRGPPPRGGMTQKL
CCCCCCCCCCCEEEC		61.13-
466PhosphorylationGMTQKLGSGRGTGQM
CCEEECCCCCCCCCC		35.44-
468MethylationTQKLGSGRGTGQMEG
EEECCCCCCCCCCCC		40.9924129315
468DimethylationTQKLGSGRGTGQMEG
EEECCCCCCCCCCCC		40.99-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of G3BP2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of G3BP2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of G3BP2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of G3BP2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of G3BP2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Large-scale phosphorylation analysis of mouse liver.";
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-225 AND THR-227, ANDMASS SPECTROMETRY.
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-227, AND MASSSPECTROMETRY.
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-227, AND MASSSPECTROMETRY.

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