dbPTM

WIZ_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WIZ_MOUSE
UniProt AC	O88286
Protein Name	Protein Wiz
Gene Name	Wiz
Organism	Mus musculus (Mouse).
Sequence Length	1684
Subcellular Localization	Nucleus .
Protein Description	May link EHMT1 and EHMT2 histone methyltransferases to the CTBP corepressor machinery. May be involved in EHMT1-EHMT2 heterodimer formation and stabilization..
Protein Sequence	MEGLLAGGLAAPDHPRGPAPREDIESGAEAAEGEGDIFPSSHYLPITKEGPRDILDGRSGISDGQPHPGLSEALPRATSATHRISSCYWDGDSLDFQPGSPPPHLLGPFPASLDVQGSWEHPMVQEAREGTPSEQRFKDSVIVRTMKPYAKLKGSRKFLHHQGEVKFLEKYSPSHHKFDWLQDTDEQGPLKDTGLHLDLPAQPPTVTSFRRVIVPVDNTPKTLDMEVMGTREDLEDFGQVAQPSEWGLHTSASEVATQTWTVNSEASVERLQPLLSPVQTGPYLCELLQEVAGGVDSNEEEEEEPAVFPCIECSIYFKHKEHLLEHMSQHRRAPGQEPPADLAPLACSECGWAFTEPTALEQHWQLHQASREKIIEEIQKLKQFPGDEGREARLQCSKCVFGTNSSRAFMQHAKLHVRGSLPSRQATEPFRGGSPVLDVSTLVYPSYGDSSGLNTCVHCGFTAPSKSLLREHTRLVHAHHAHWEEVGEAFEDLTSQPCTSQDAYTHSPDTATVDYFSKSEPLLASVWQENPSGYDPDLAFGPDYQQPGMRNFPLLNSGQQSLGKLAFPSPMASASYSIQRNRNKSTVHLQRMEDKSHLWSEEEEEEDEDVVLTSERDFTPENGAFPPLAIPSLIPQPALELKQTFQDALQAVDASETQQQQLQGMVPIVLMAKLRPQVIAATTRASPQLPPEEPELRSTHPLDFLLLDAPLGGSLGLNTLLEGDPAMALKHEERKCPYCPDRFHYGIGLANHVRGHLNRVGVSYNVRHFISAEEVKAIERRFSFQKKKKKVANFDPGTFSLMRCDFCGAGFDTRAGLSSHARAHLRDFGITNWELTISPINILQELLATSAAELPPSPLGREPGGPPRSFLTSRRPRLPLTMPFPPTWAEDPGPIYGDAQSLTTCEVCGACFETRKGLSSHARSHLRQLGVAESESSGAPIDLLYELVKQKGLPDAPLGLTPSLTKKSNSPKEFLAGAARPGLLTLAKPMDAPAVNKAIKSPPGFSAKGLTHPSSSPLLKKAPLTLAGSPTPKNPEDKSPQLSLSPRPTSPKAQWPQSEDEGPLNLTSGPEPTRDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWYVNGSPIDTLREILKRRTQSRPGGHLHPPGPSPKALAKVLSTGGPGSSLEARSPSDLHISPLTKKLPPPPGSPLGHSPTASPPPTARKMFSGLATPSLPKKLKPEHMRVEIKREMLPGTLHGEPHPSEGPWGTPREDMAPLNLSARAEPVRDIRCEFCGEFFENRKGLSSHARSHLRQMGVTEWSVNGSPIDTLREILKKKSKLCLIKKEPPAGDLAPALTEDGSPTAAPGALHSPLPLSPLASRPGKPGAGPTQVPRELSLSPITGSKPSAASYLGPVATKRPLQEDRFLPAEVKAKTYIQTELPFKAKTLHEKTSHSSTEACCELCGLYFENRKALASHARAHLRQFGVTEWCVNGSPIETLSEWIKHRPQKVGAYRSYIQGGRPFTKKFRSAGHGRDSDKRPPLGLAPGGLSLVGRSAGGEPGLEAGRAADSGERPLATSPPGTVKSEEHQRQNINKFERRQARPSDASAARGGEEVNDLQQKLEEVRQPPPRVRPVPSLVPRPPQTSLVKFVGNIYTLKCRFCEVEFQGPLSIQEEWVRHLQRHILEMNFSKADPPPEEPQAPQAQTAAVEAP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162 (in isoform 3)	Phosphorylation	-	38.71	25338131
211	Methylation	PTVTSFRRVIVPVDN CCCCCCEEEEEECCC	22.09	18967371
273	Phosphorylation	ASVERLQPLLSPVQT HHHHHHHHHCCCCCC	39.60	24719451
288	Phosphorylation	GPYLCELLQEVAGGV HHHHHHHHHHHHCCC	1.58	24719451
301	Phosphorylation	GVDSNEEEEEEPAVF CCCCCCHHHCCCCCC	65.61	24719451
949	Ubiquitination	DLLYELVKQKGLPDA HHHHHHHHHCCCCCC	59.94	-
970	Phosphorylation	SLTKKSNSPKEFLAG CCCCCCCCCHHHHHH	44.43	21082442
988	Acetylation	PGLLTLAKPMDAPAV CCCHHEECCCCCHHH	43.94	23806337
1001	Phosphorylation	AVNKAIKSPPGFSAK HHHHHHCCCCCCCCC	30.16	26643407
1006	Phosphorylation	IKSPPGFSAKGLTHP HCCCCCCCCCCCCCC	34.68	28066266
1011	Phosphorylation	GFSAKGLTHPSSSPL CCCCCCCCCCCCCCH	40.17	24453211
1014	Phosphorylation	AKGLTHPSSSPLLKK CCCCCCCCCCCHHHH	35.52	27566939
1015	Phosphorylation	KGLTHPSSSPLLKKA CCCCCCCCCCHHHHC	40.19	22942356
1016	Phosphorylation	GLTHPSSSPLLKKAP CCCCCCCCCHHHHCC	24.73	26824392
1025	Phosphorylation	LLKKAPLTLAGSPTP HHHHCCCEECCCCCC	17.32	25619855
1029	Phosphorylation	APLTLAGSPTPKNPE CCCEECCCCCCCCCC	21.72	27087446
1031	Phosphorylation	LTLAGSPTPKNPEDK CEECCCCCCCCCCCC	48.90	22942356
1039	Phosphorylation	PKNPEDKSPQLSLSP CCCCCCCCCCCCCCC	30.15	26824392
1043	Phosphorylation	EDKSPQLSLSPRPTS CCCCCCCCCCCCCCC	22.89	26824392
1045	Phosphorylation	KSPQLSLSPRPTSPK CCCCCCCCCCCCCCC	18.58	26824392
1049	Phosphorylation	LSLSPRPTSPKAQWP CCCCCCCCCCCCCCC	59.96	25521595
1050	Phosphorylation	SLSPRPTSPKAQWPQ CCCCCCCCCCCCCCC	27.38	26824392
1058	Phosphorylation	PKAQWPQSEDEGPLN CCCCCCCCCCCCCCC	42.83	25619855
1105	Phosphorylation	HLRQMGVTEWYVNGS HHHHCCCCEEEECCC	18.31	-
1112	Phosphorylation	TEWYVNGSPIDTLRE CEEEECCCHHHHHHH	17.30	26745281
1139	Phosphorylation	HLHPPGPSPKALAKV CCCCCCCCHHHHHHH	44.97	25266776
1148	Phosphorylation	KALAKVLSTGGPGSS HHHHHHHHCCCCCCC	28.17	25266776
1149	Phosphorylation	ALAKVLSTGGPGSSL HHHHHHHCCCCCCCC	41.83	26643407
1154	Phosphorylation	LSTGGPGSSLEARSP HHCCCCCCCCCCCCC	34.58	26643407
1155	Phosphorylation	STGGPGSSLEARSPS HCCCCCCCCCCCCCC	35.82	26643407
1160	Phosphorylation	GSSLEARSPSDLHIS CCCCCCCCCCCCCCC	35.48	26824392
1162	Phosphorylation	SLEARSPSDLHISPL CCCCCCCCCCCCCCC	54.79	22942356
1167	Phosphorylation	SPSDLHISPLTKKLP CCCCCCCCCCCCCCC	11.78	26824392
1170	Phosphorylation	DLHISPLTKKLPPPP CCCCCCCCCCCCCCC	29.53	25619855
1179	Phosphorylation	KLPPPPGSPLGHSPT CCCCCCCCCCCCCCC	23.79	27087446
1184	Phosphorylation	PGSPLGHSPTASPPP CCCCCCCCCCCCCCC	23.34	27087446
1186	Phosphorylation	SPLGHSPTASPPPTA CCCCCCCCCCCCCCH	42.66	21082442
1188	Phosphorylation	LGHSPTASPPPTARK CCCCCCCCCCCCHHH	40.18	27087446
1192	Phosphorylation	PTASPPPTARKMFSG CCCCCCCCHHHHHCC	44.88	25619855
1195	Methylation	SPPPTARKMFSGLAT CCCCCHHHHHCCCCC	41.66	-
1195	"N6,N6,N6-trimethyllysine"	SPPPTARKMFSGLAT CCCCCHHHHHCCCCC	41.66	-
1240	Phosphorylation	PSEGPWGTPREDMAP CCCCCCCCCHHHHCC	18.46	29514104
1251	Phosphorylation	DMAPLNLSARAEPVR HHCCCCCCCCCCCCC	18.03	25266776
1289	Phosphorylation	HLRQMGVTEWSVNGS HHHHCCCCCCEECCC	26.47	23984901
1292	Phosphorylation	QMGVTEWSVNGSPID HCCCCCCEECCCHHH	10.24	23984901
1296	Phosphorylation	TEWSVNGSPIDTLRE CCCEECCCHHHHHHH	17.30	23984901
1328	Phosphorylation	GDLAPALTEDGSPTA CCCCCCCCCCCCCCC	33.85	25777480
1332	Phosphorylation	PALTEDGSPTAAPGA CCCCCCCCCCCCCCC	31.25	25777480
1334	Phosphorylation	LTEDGSPTAAPGALH CCCCCCCCCCCCCCC	36.83	25777480
1342	Phosphorylation	AAPGALHSPLPLSPL CCCCCCCCCCCCCCC	29.05	25777480
1347	Phosphorylation	LHSPLPLSPLASRPG CCCCCCCCCCCCCCC	18.87	25777480
1351	Phosphorylation	LPLSPLASRPGKPGA CCCCCCCCCCCCCCC	46.84	25777480
1361	Phosphorylation	GKPGAGPTQVPRELS CCCCCCCCCCCCCEE	41.08	25777480
1368	Phosphorylation	TQVPRELSLSPITGS CCCCCCEECCCCCCC	23.27	22942356
1370	Phosphorylation	VPRELSLSPITGSKP CCCCEECCCCCCCCC	15.75	26824392
1373	Phosphorylation	ELSLSPITGSKPSAA CEECCCCCCCCCCHH	38.49	25619855
1375	Phosphorylation	SLSPITGSKPSAASY ECCCCCCCCCCHHHH	32.51	25619855
1415	Acetylation	IQTELPFKAKTLHEK EEEECCCCCEECCHH	47.21	8275587
1417	Acetylation	TELPFKAKTLHEKTS EECCCCCEECCHHCC	52.81	8275597
1422	Acetylation	KAKTLHEKTSHSSTE CCEECCHHCCCCHHH	44.58	8275607
1488	Phosphorylation	KVGAYRSYIQGGRPF CCCHHHHHHCCCCCC	6.56	-
1542	Phosphorylation	EAGRAADSGERPLAT HHCCCCCCCCCCCCC	37.52	25619855
1549	Phosphorylation	SGERPLATSPPGTVK CCCCCCCCCCCCCCC	49.83	26824392
1550	Phosphorylation	GERPLATSPPGTVKS CCCCCCCCCCCCCCC	24.40	26824392
1554	Phosphorylation	LATSPPGTVKSEEHQ CCCCCCCCCCCHHHH	30.45	25619855
1576	Phosphorylation	ERRQARPSDASAARG HHHHCCCCHHHHHCC	40.01	25338131
1630	Ubiquitination	VGNIYTLKCRFCEVE CCCEEEEEEEEEEEE	18.63	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1016	S	Phosphorylation	Kinase	MAPK1	P63085	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WIZ_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WIZ_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CETN2_HUMAN	CETN2	physical	26496610
ICLN_HUMAN	CLNS1A	physical	26496610
IF4B_HUMAN	EIF4B	physical	26496610
GOGA4_HUMAN	GOLGA4	physical	26496610
HDAC2_HUMAN	HDAC2	physical	26496610
P4HA1_HUMAN	P4HA1	physical	26496610
KPRA_HUMAN	PRPSAP1	physical	26496610
REST_HUMAN	REST	physical	26496610
MKNK1_HUMAN	MKNK1	physical	26496610
CDYL_HUMAN	CDYL	physical	26496610
RBM7_HUMAN	RBM7	physical	26496610
TBB3_HUMAN	TUBB3	physical	26496610
EHMT2_HUMAN	EHMT2	physical	26496610
MDN1_HUMAN	MDN1	physical	26496610
UBR4_HUMAN	UBR4	physical	26496610
NNTM_HUMAN	NNT	physical	26496610
LCOR_HUMAN	C10orf12	physical	26496610
MIER2_HUMAN	MIER2	physical	26496610
COPRS_HUMAN	COPRS	physical	26496610
MIER1_HUMAN	MIER1	physical	26496610
EHMT1_HUMAN	EHMT1	physical	26496610
ZN644_HUMAN	ZNF644	physical	26496610
CDYL2_HUMAN	CDYL2	physical	26496610
SDE2_HUMAN	SDE2	physical	26496610

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WIZ_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Large scale localization of protein phosphorylation by use ofelectron capture dissociation mass spectrometry."; Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.; Mol. Cell. Proteomics 8:904-912(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1050, AND MASSSPECTROMETRY.	19131326 [Abstract]
"Large-scale phosphorylation analysis of mouse liver."; Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1045; THR-1049 ANDSER-1050, AND MASS SPECTROMETRY.	17242355 [Abstract]