RBBP5_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBBP5_MOUSE
• UniProt AC: Q8BX09
• Protein Name: Retinoblastoma-binding protein 5
• Gene Name: Rbbp5
• Organism: Mus musculus (Mouse).
• Sequence Length: 538
• Subcellular Localization: Nucleus.
• Protein Description: As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal..
• Protein Sequence: MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVPSSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSTKGKVQAELSQSLAAGGAISELL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
192	Phosphorylation	LVASFRVTTGTSNTT EEEEEEEEECCCCCC	18.43	29895711
193	Phosphorylation	VASFRVTTGTSNTTA EEEEEEEECCCCCCE	35.29	29895711
195	Phosphorylation	SFRVTTGTSNTTAIK EEEEEECCCCCCEEE	19.40	29895711
196	Phosphorylation	FRVTTGTSNTTAIKS EEEEECCCCCCEEEE	33.26	29895711
198	Phosphorylation	VTTGTSNTTAIKSIE EEECCCCCCEEEEEE	19.85	29895711
209	Acetylation	KSIEFARKGSCFLIN EEEEEHHCCCEEEEE	52.31	7712699
244	Ubiquitination	GEPEPMQKLQDLVNR CCCCHHHHHHHHHHC	41.69	22790023
252	Phosphorylation	LQDLVNRTPWKKCCF HHHHHHCCCCCCCCC	28.44	-
345	Phosphorylation	ELDENVEYEERESEF HHHHCCCHHHHHCCC	20.86	26643407
350	Phosphorylation	VEYEERESEFDIEDE CCHHHHHCCCCCCCC	50.19	25521595
388	Phosphorylation	DPIAAFCSSDEELED CHHHHHCCCCHHHCC	34.08	25195567
389	Phosphorylation	PIAAFCSSDEELEDS HHHHHCCCCHHHCCC	50.66	25195567
440	Phosphorylation	SSEKKRQSSADGSQP CCHHHHHCCCCCCCC	31.37	25266776
441	Phosphorylation	SEKKRQSSADGSQPP CHHHHHCCCCCCCCC	23.26	23684622
445	Phosphorylation	RQSSADGSQPPKKKP HHCCCCCCCCCCCCC	39.81	29550500
497	Phosphorylation	SKGKEKDSPFKPKLY CCCCCCCCCCCCCCC	43.22	25266776
515	Phosphorylation	RGLPLEGSTKGKVQA CCCCCCCCCCCHHHH	19.99	-
516	Phosphorylation	GLPLEGSTKGKVQAE CCCCCCCCCCHHHHH	55.46	-
525	Phosphorylation	GKVQAELSQSLAAGG CHHHHHHHHHHHHCC	14.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
252	T	Phosphorylation	Kinase	CDK1	P11440	Uniprot
497	S	Phosphorylation	Kinase	CDK1	P11440	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBBP5_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBBP5_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WDR5_MOUSE	Wdr5	physical	17825402
ASH2L_MOUSE	Ash2l	physical	17825402
PHF20_MOUSE	Phf20	physical	23452852

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.