ASH2L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASH2L_MOUSE
• UniProt AC: Q91X20
• Protein Name: Set1/Ash2 histone methyltransferase complex subunit ASH2
• Gene Name: Ash2l
• Organism: Mus musculus (Mouse).
• Sequence Length: 623
• Subcellular Localization: Nucleus .
• Protein Description: Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (By similarity)..
• Protein Sequence: MAAAGAGPGPGVSAGPGPGAAASATTAEDRETEPVAAGAGEGPSAAPGAEPSSGEAESGDANLVDVSGLETESSNGKDTLEGTGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSASGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYRDIFEGVYFPAISLYKSCTVSINFGPSFKYPPKDLTYHPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
73	Phosphorylation	VSGLETESSNGKDTL ECCCEEECCCCCCCE	36.20	28973931
74	Phosphorylation	SGLETESSNGKDTLE CCCEEECCCCCCCEE	43.29	25338131
92	Phosphorylation	DTSEVMDTQAGSVDE CHHHHHCCCCCCCCC	11.39	21183079
96	Phosphorylation	VMDTQAGSVDEENGR HHCCCCCCCCCCCCE	29.43	27087446
136	Phosphorylation	SSCLPFMTNYSFHCN HHCHHCCCCEEEEEE	31.24	-
138	Phosphorylation	CLPFMTNYSFHCNVC CHHCCCCEEEEEEEC	11.98	-
139	Phosphorylation	LPFMTNYSFHCNVCH HHCCCCEEEEEEECC	15.58	-
269	Phosphorylation	AYDNQKQSSAVSASG CCCCCCCCCCEECCC	27.57	-
270	Phosphorylation	YDNQKQSSAVSASGN CCCCCCCCCEECCCC	30.14	-
273	Phosphorylation	QKQSSAVSASGNLNG CCCCCCEECCCCCCC	19.21	29109428
275	Phosphorylation	QSSAVSASGNLNGGI CCCCEECCCCCCCCC	22.25	-
286	Phosphorylation	NGGIAAGSSGKGRGA CCCCCCCCCCCCCCC	31.06	29109428
291	Methylation	AGSSGKGRGAKRKQQ CCCCCCCCCCCCCCC	45.44	-
291	Asymmetric dimethylarginine	AGSSGKGRGAKRKQQ CCCCCCCCCCCCCCC	45.44	-
311	Phosphorylation	GTTKKARSDPLFSAQ CCCCCCCCCCCCCCC	48.73	26643407
316	Phosphorylation	ARSDPLFSAQRLPPH CCCCCCCCCCCCCCC	31.04	28066266
618	Phosphorylation	TEVDGRRSPPWEP-- ECCCCCCCCCCCC--	33.67	25521595

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASH2L_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASH2L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASH2L_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP2D_MOUSE	Tfap2d	physical	20046871
TBX1_MOUSE	Tbx1	physical	20463296
NFE2_MOUSE	Nfe2	physical	17707229
RBBP5_MOUSE	Rbbp5	physical	17707229
MAFK_MOUSE	Mafk	physical	17707229

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.