AP2D_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AP2D_MOUSE
• UniProt AC: Q91ZK0
• Protein Name: Transcription factor AP-2-delta
• Gene Name: Tfap2d
• Organism: Mus musculus (Mouse).
• Sequence Length: 452
• Subcellular Localization: Nucleus .
• Protein Description: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC..
• Protein Sequence: MSTTFPGLVHDAEIRHDGSNSYRLMQLGCLESVANSTVAYSSSSPLTYSTTGTEFASPYFSTNHQYTPLHHQSFHYEFQHSHPAVTPDAYSLNSLHHSQQYYQQIHHGEPTDFINLHNARALKSSCLDEQRRELGCLDAYRRHDLSLMSHGSQYGMHPDQRLLPGPSLGLAAAGADDLQGSVEAQCGIVLNGQGGVIRRGGTCVVNPTDLFCSVPGRLSLLSSTSKYKVTIAEVKRRLSPPECLNASLLGGILRRAKSKNGGRCLREKLDRLGLNLPAGRRKAANVTLLTSLVEGEALHLARDFGYTCETEFPAKAVGEHLARQHMEQKEQTARKKMILATKQICKEFQDLLSQDRSPLGSSRPTPILDLDIQRHLTHFSLITHGFGTPAICAALSTFQTVLSEMLNYLEKHTTHKNGGAADSGQGHANSEKAPLRKASEAAVKEGKTEKTD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
219	Phosphorylation	CSVPGRLSLLSSTSK CCCCCCHHHCCCCCC	26.38	-
223	Phosphorylation	GRLSLLSSTSKYKVT CCHHHCCCCCCEEEE	36.35	29514104
225	Phosphorylation	LSLLSSTSKYKVTIA HHHCCCCCCEEEEHH	35.62	29514104
235	Malonylation	KVTIAEVKRRLSPPE EEEHHHHHHHCCCHH	24.25	26320211
239	Phosphorylation	AEVKRRLSPPECLNA HHHHHHCCCHHHHCH	36.28	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
239	S	Phosphorylation	Kinase	PKA	-	Uniprot

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AP2D_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AP2D_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AP2D_MOUSE	Tfap2d	physical	20211142
AP2D_MOUSE	Tfap2d	physical	11522791

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.