MAFK_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAFK_MOUSE
• UniProt AC: Q61827
• Protein Name: Transcription factor MafK
• Gene Name: Mafk
• Organism: Mus musculus (Mouse).
• Sequence Length: 156
• Subcellular Localization: Nucleus.
• Protein Description: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor..
• Protein Sequence: MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVTPTKVATTSVITIVKSAELSSTSVPFSAAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Phosphorylation	GENAPVLSDDELVSM CCCCCCCCHHHHHHH	43.16	27087446
31	Phosphorylation	LSDDELVSMSVRELN CCHHHHHHHHHHHHH	20.26	28066266
33	Phosphorylation	DDELVSMSVRELNQH HHHHHHHHHHHHHHH	15.54	28066266
127	Phosphorylation	TVARGPVTPTKVATT HHHCCCCCCCCEEEC	28.51	28833060
129	Phosphorylation	ARGPVTPTKVATTSV HCCCCCCCCEEECEE	28.87	26745281
134	Phosphorylation	TPTKVATTSVITIVK CCCCEEECEEEEEEE	15.97	-
134	O-linked_Glycosylation	TPTKVATTSVITIVK CCCCEEECEEEEEEE	15.97	30059200

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAFK_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAFK_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAFK_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NF2L2_MOUSE	Nfe2l2	physical	20211142
NR4A3_MOUSE	Nr4a3	physical	20211142
BACH2_MOUSE	Bach2	physical	17046816

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.