BACH2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BACH2_MOUSE
• UniProt AC: P97303
• Protein Name: Transcription regulator protein BACH2
• Gene Name: Bach2
• Organism: Mus musculus (Mouse).
• Sequence Length: 839
• Subcellular Localization: Cytoplasm . Nucleus . Nucleocytoplasmic shuttling is controlled by phosphorylation.
• Protein Description: Transcriptional regulator that acts as repressor or activator. [PubMed: 8887638 Binds to Maf recognition elements (MARE)]
• Protein Sequence: MSVDEKPGSPMYVYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNREDGLFVCRKDSACQRPQEDHGNSAGEEEEEEETMDSETARMACATDQMLPDPISFEATAIPVAEKEEALLPESEVPTDTKENSEKGALTQYPRYKKYQLACTKNVYSAPSHGTSGFASTFSEDSPGNSLKPGLPMGQIKSEPPSEETEEESITLCLSGDETDIKDRPGDVEMDRKQPSPAPTPSTPTGAACLDRSRSVSSPSCLRSLFGITKGVESTGLPSTSQQPLVRSSACPFNKGISQGDLKTDYTPLAGNYGQPHVGQKDVSNFAMGSPLRGPGPETLCKQEGELDRRSVIFSASACDQPNTPVHSYSAVSNLDKDLSEPVPKSLWVGAGQSLPSSQAYSHSGLMADHLPGRIRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLIPMDLPGASVNPPPVGVEQSLAPSPCAVGGSVPCCLEPGAAPPGLPWVPSNTSENCTSGRRLEGSDPGTFSERGPPLEARSQSVTVDFCQEMTEKCTTDEQPRKDYA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
40	Phosphorylation	KDILCDVTLIVERKE HHCEEEEEEEEECHH	9.49	-
131	Phosphorylation	SCFSFLQTQLLNRED HHHHHHHHHHHCCCC	24.27	-
147	Phosphorylation	LFVCRKDSACQRPQE EEEECCCCCCCCCCC	33.70	23684622
159	Phosphorylation	PQEDHGNSAGEEEEE CCCCCCCCCCCHHHH	42.09	25266776
169	Phosphorylation	EEEEEEETMDSETAR CHHHHHHHCCHHHHH	29.56	20469934
172	Phosphorylation	EEEETMDSETARMAC HHHHHCCHHHHHHHH	26.48	20469934
174	Phosphorylation	EETMDSETARMACAT HHHCCHHHHHHHHHH	24.42	20469934
201	Sumoylation	TAIPVAEKEEALLPE EEEEHHHHHHHHCCC	51.63	-
219	Phosphorylation	PTDTKENSEKGALTQ CCCCCCCCCCCCCCC	41.60	-
249	Phosphorylation	YSAPSHGTSGFASTF ECCCCCCCCCCCCCC	21.91	-
250	Phosphorylation	SAPSHGTSGFASTFS CCCCCCCCCCCCCCC	36.18	-
254	Phosphorylation	HGTSGFASTFSEDSP CCCCCCCCCCCCCCC	27.94	-
255	Phosphorylation	GTSGFASTFSEDSPG CCCCCCCCCCCCCCC	27.96	-
257	Phosphorylation	SGFASTFSEDSPGNS CCCCCCCCCCCCCCC	40.35	-
260	Phosphorylation	ASTFSEDSPGNSLKP CCCCCCCCCCCCCCC	30.56	-
264	Phosphorylation	SEDSPGNSLKPGLPM CCCCCCCCCCCCCCC	43.62	-
275	Sumoylation	GLPMGQIKSEPPSEE CCCCCCCCCCCCCCC	40.66	-
280	Phosphorylation	QIKSEPPSEETEEES CCCCCCCCCCCCCCC	59.80	-
283	Phosphorylation	SEPPSEETEEESITL CCCCCCCCCCCCEEE	44.65	-
287	Phosphorylation	SEETEEESITLCLSG CCCCCCCCEEEEECC	24.93	-
289	Phosphorylation	ETEEESITLCLSGDE CCCCCCEEEEECCCC	22.24	-
293	Phosphorylation	ESITLCLSGDETDIK CCEEEEECCCCCCCC	43.11	-
297	Phosphorylation	LCLSGDETDIKDRPG EEECCCCCCCCCCCC	48.00	-
314	Phosphorylation	EMDRKQPSPAPTPST CCCCCCCCCCCCCCC	31.06	21082442
318	Phosphorylation	KQPSPAPTPSTPTGA CCCCCCCCCCCCCCC	31.79	27566939
320	Phosphorylation	PSPAPTPSTPTGAAC CCCCCCCCCCCCCHH	49.88	25266776
321	Phosphorylation	SPAPTPSTPTGAACL CCCCCCCCCCCCHHH	26.52	28833060
323	Phosphorylation	APTPSTPTGAACLDR CCCCCCCCCCHHHCC	39.27	28833060
331	Phosphorylation	GAACLDRSRSVSSPS CCHHHCCCCCCCCHH	28.68	-
333	Phosphorylation	ACLDRSRSVSSPSCL HHHCCCCCCCCHHHH	27.83	23527152
335	Phosphorylation	LDRSRSVSSPSCLRS HCCCCCCCCHHHHHH	37.47	23527152
336	Phosphorylation	DRSRSVSSPSCLRSL CCCCCCCCHHHHHHH	20.76	29895711
338	Phosphorylation	SRSVSSPSCLRSLFG CCCCCCHHHHHHHHC	27.94	-
342	Phosphorylation	SSPSCLRSLFGITKG CCHHHHHHHHCCCCC	18.33	-
347	Phosphorylation	LRSLFGITKGVESTG HHHHHCCCCCHHHCC	23.33	-
353	Phosphorylation	ITKGVESTGLPSTSQ CCCCHHHCCCCCCCC	29.27	22871156
358	Phosphorylation	ESTGLPSTSQQPLVR HHCCCCCCCCCCCCC	28.72	22871156
359	Phosphorylation	STGLPSTSQQPLVRS HCCCCCCCCCCCCCC	31.02	22871156
376	Phosphorylation	CPFNKGISQGDLKTD CCCCCCCCCCCCCCC	36.46	28833060
382	Phosphorylation	ISQGDLKTDYTPLAG CCCCCCCCCCCCCCC	41.35	-
385	Phosphorylation	GDLKTDYTPLAGNYG CCCCCCCCCCCCCCC	18.03	-
402	Phosphorylation	HVGQKDVSNFAMGSP CCCCCCCCCCCCCCC	36.04	-
408 (in isoform 2)	Phosphorylation	-	14.00	25266776
408	Phosphorylation	VSNFAMGSPLRGPGP CCCCCCCCCCCCCCH	14.00	28833060
417	Phosphorylation	LRGPGPETLCKQEGE CCCCCHHHCCCCCCC	40.36	-
420	Sumoylation	PGPETLCKQEGELDR CCHHHCCCCCCCCCC	51.93	-
429	Phosphorylation	EGELDRRSVIFSASA CCCCCCCEEEEEECC	11.48	-
433	Phosphorylation	DRRSVIFSASACDQP CCCEEEEEECCCCCC	4.86	-
435	Phosphorylation	RSVIFSASACDQPNT CEEEEEECCCCCCCC	35.83	-
442	Phosphorylation	SACDQPNTPVHSYSA CCCCCCCCCCCCCCC	5.19	-
446	Phosphorylation	QPNTPVHSYSAVSNL CCCCCCCCCCCCCCC	18.10	-
448	Phosphorylation	NTPVHSYSAVSNLDK CCCCCCCCCCCCCCC	14.15	-
509	Phosphorylation	PIKVCPRSPPLETRT CEEECCCCCCCCCEE	1.53	23140645
514	Phosphorylation	PRSPPLETRTRTSSS CCCCCCCCEEECCCC	50.38	29472430
518	Phosphorylation	PLETRTRTSSSCSSY CCCCEEECCCCCCCC	54.68	-
519	Phosphorylation	LETRTRTSSSCSSYS CCCEEECCCCCCCCE	46.16	-
520	Phosphorylation	ETRTRTSSSCSSYSY CCEEECCCCCCCCEE	5.21	-
521	Phosphorylation	TRTRTSSSCSSYSYA CEEECCCCCCCCEEC	42.10	-
523	Phosphorylation	TRTSSSCSSYSYAED EECCCCCCCCEECCC	1.77	-
524	Phosphorylation	RTSSSCSSYSYAEDG ECCCCCCCCEECCCC	29.75	-
526	Phosphorylation	SSSCSSYSYAEDGSG CCCCCCCEECCCCCC	1.98	-
532	Phosphorylation	YSYAEDGSGGSPCSL CEECCCCCCCCCCCC	41.66	-
535	Phosphorylation	AEDGSGGSPCSLPLC CCCCCCCCCCCCEEC	8.36	-
538	Phosphorylation	GSGGSPCSLPLCEFS CCCCCCCCCEECCCC	19.92	-
545	Phosphorylation	SLPLCEFSSSPCSQG CCEECCCCCCCCHHH	30.43	-
546	Phosphorylation	LPLCEFSSSPCSQGA CEECCCCCCCCHHHH	5.10	-
547	Phosphorylation	PLCEFSSSPCSQGAR EECCCCCCCCHHHHH	2.80	-
550	Phosphorylation	EFSSSPCSQGARFLA CCCCCCCHHHHHHHE	4.58	-
571	Phosphorylation	GLMGDGMYNQVRPQI CCCCCCCCCCCCCCC	4.26	-
579	Sumoylation	NQVRPQIKCEQSYGT CCCCCCCEEEECCCC	4.38	-
586	Phosphorylation	KCEQSYGTNSSDESG EEEECCCCCCCCCCC	28.73	-
588	Phosphorylation	EQSYGTNSSDESGSF EECCCCCCCCCCCCC	39.96	-
589	Phosphorylation	QSYGTNSSDESGSFS ECCCCCCCCCCCCCC	2.22	-
592	Phosphorylation	GTNSSDESGSFSEAD CCCCCCCCCCCCCCC	37.85	-
594	Phosphorylation	NSSDESGSFSEADSE CCCCCCCCCCCCCCC	58.17	-
596	Phosphorylation	SDESGSFSEADSESC CCCCCCCCCCCCCCC	22.57	-
639	Phosphorylation	MIKMHKLTSEQLEFI HHHHHCCCHHHHHHH	20.90	24719451
640	Phosphorylation	IKMHKLTSEQLEFIH HHHHCCCHHHHHHHH	19.56	24719451
718	Phosphorylation	EVCRDIQSPEQIQAL HHHHHCCCHHHHHHH		-
797	Phosphorylation	SGRRLEGSDPGTFSE CCCCCCCCCCCCCCC		-
801	Phosphorylation	LEGSDPGTFSERGPP CCCCCCCCCCCCCCC		-
803	Phosphorylation	GSDPGTFSERGPPLE CCCCCCCCCCCCCCC		-
813	Phosphorylation	GPPLEARSQSVTVDF CCCCCHHCCCEEEHH		28833060
815	Phosphorylation	PLEARSQSVTVDFCQ CCCHHCCCEEEHHHH		28833060
817	Phosphorylation	EARSQSVTVDFCQEM CHHCCCEEEHHHHHH		20469934
825	Phosphorylation	VDFCQEMTEKCTTDE EHHHHHHHHHCCCCC		20469934

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
520	S	Phosphorylation	Kinase	AKT1	P31749	PSP
520	S	Phosphorylation	Kinase	AKT1	P31750	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
520	S	Phosphorylation	Phosphorylation at Ser-520 downstream of the PI-3K pathway promotes nuclear export.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BACH2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PRDM1_MOUSE	Prdm1	genetic	20953163
BACH2_MOUSE	Bach2	physical	16331266
BCL6_MOUSE	Bcl6	physical	16331266
BCL6B_MOUSE	Bcl6b	physical	16331266

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.