PRDM1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRDM1_MOUSE
• UniProt AC: Q60636
• Protein Name: PR domain zinc finger protein 1
• Gene Name: Prdm1
• Organism: Mus musculus (Mouse).
• Sequence Length: 856
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. [PubMed: 27102484 Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection]
• Protein Sequence: MREAYLRCWIFSWKNVWVRPCQRLHFKTVLLQGSLLYTALDSYSTVQAAPKSSSGSVKFQGLAETGIMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYAANNSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTVINLTQTESNPKQYSSEKNELYPKSVPKREYSVKEILKLDSNPSKRKDIYRSNISPFTLEKDMDGFRKNGSPDMPFYPRVVYPIRAPLPEDFLKASLAYGMERPTYITHSPLPSSTTPSPPASSSPEQSLKSSSPHSSPGNTVSPLAPGLPEHRDSYSYLNVSYGSEGLGSYPGYAPAPHLPPAFIPSYNAHYPKFLLPPYGISSNGLSTMNNINGINNFSLFPRLYPVYSNLLSGSSLPHPMLNPASLPSSLPTDGARRLLPPEHPKEVLIPAPHSAFSLTGAAASMKDESSPPSGSPTAGTAATSEHVVQPKATSSVMAAPSTDGAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCAQCHKSYIHLCSLKVHLKGNCPAGPAAGLPLEDLTRINEEIERFDISDNADRLEDMEDSVDVTSMVEKEILAVVRKEKEETSLKVSLQRNMGNGLLSSGCSLYESSDLSLMKLPHSNPLPLVPVKVKQETVEPMDP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10 (in isoform 4)	Phosphorylation	-	1.93	30635358
135	Phosphorylation	KEVIGVVSKEYIPKG CEEEEEEEHHHCCCC	19.84	28059163
280	Phosphorylation	KSVPKREYSVKEILK CCCCCCCCCHHHHHC	23.85	25338131
281	Phosphorylation	SVPKREYSVKEILKL CCCCCCCCHHHHHCC	23.20	25338131
293	Phosphorylation	LKLDSNPSKRKDIYR HCCCCCHHHCHHHHH	49.71	28418008
304	Phosphorylation	DIYRSNISPFTLEKD HHHHCCCCCCCEEEC	20.43	25266776
320	Phosphorylation	DGFRKNGSPDMPFYP CCCHHCCCCCCCCCC	27.41	25266776
541	Phosphorylation	AASMKDESSPPSGSP HHHCCCCCCCCCCCC	59.27	23375375
542	Phosphorylation	ASMKDESSPPSGSPT HHCCCCCCCCCCCCC	38.49	23375375
545	Phosphorylation	KDESSPPSGSPTAGT CCCCCCCCCCCCCCC	56.11	23375375
547	Phosphorylation	ESSPPSGSPTAGTAA CCCCCCCCCCCCCCC	24.34	23375375
549	Phosphorylation	SPPSGSPTAGTAATS CCCCCCCCCCCCCCC	39.14	23375375
565	Phosphorylation	HVVQPKATSSVMAAP CCCCCCCCCCCEECC	27.88	-
657	Phosphorylation	QKHYLVHTGEKPHEC HHHEEEECCCCCCCC	39.29	23140645

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRDM1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
847	K	Sumoylation	Sumoylation at Lys-847 by PIAS1 increases transcriptional repressor activity, and is critical for plasma cell differentiation (By similarity).	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRDM1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRF4_HUMAN	IRF4	physical	11342629
IKKB_MOUSE	Ikbkb	genetic	21156282
ETS1_MOUSE	Ets1	physical	17977828
ANM5_HUMAN	PRMT5	physical	16699504
PRDM1_MOUSE	Prdm1	physical	22851713

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.