NR4A3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NR4A3_MOUSE
• UniProt AC: Q9QZB6
• Protein Name: Nuclear receptor subfamily 4 group A member 3
• Gene Name: Nr4a3
• Organism: Mus musculus (Mouse).
• Sequence Length: 627
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional activator that binds to regulatory elements in promoter regions in a cell- and response element (target)-specific manner. [PubMed: 12709428 Induces gene expression by binding as monomers to the NR4A1 response element (NBRE) 5'-AAAAGGTCA-3' site and as homodimers to the Nur response element (NurRE) site in the promoter of their regulated target genes (By similarity Plays a role in the regulation of proliferation, survival and differentiation of many different cell types and also in metabolism and inflammation. Mediates proliferation of vascular smooth muscle, myeloid progenitor cell and type B pancreatic cells; promotes mitogen-induced vascular smooth muscle cell proliferation through transactivation of SKP2 promoter by binding a NBRE site]
• Protein Sequence: MPCVQAQYSPSPPGSTYATQTYGSEYTTEIMNPDYTKLTMDLGSTGIMATATTSLPSFSTFMEGYPSSCELKPSCLYQMPPSGPRPLIKMEEGREHGYHHHHHHHHHHHHHQQQQPSIPPPSGPEDEVLPSTSMYFKQSPPSTPTTPGFPPQAGALWDDELPSAPGCIAPGPLLDPQMKAVPPMAAAARFPIFFKPSPPHPPAPSPAGGHHLGYDPTAAAALSLPLGAAAAAGSQAAALEGHPYGLPLAKRTATLTFPPLGLTASPTASSLLGESPSLPSPPNRSSSSGEGTCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRRNRCQYCRFQKCLSVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSPPICMMNALVRALTDATPRDLDYSRYCPTDQATAGTDAEHVQQFYNLLTASIDVSRSWAEKIPGFTDLPKEDQTLLIESAFLELFVLRLSIRSNTAEDKFVFCNGLVLHRLQCLRGFGEWLDSIKDFSLNLQSLNLDIQALACLSALSMITERHGLKEPKRVEELCTKITSSLKDHQRKGQALEPSEPKVLRALVELRKICTQGLQRIFYLKLEDLVPPPSVIDKLFLDTLPF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
265	Phosphorylation	PPLGLTASPTASSLL CCCCCCCCCCHHHHC	19.97	28285833
275	Phosphorylation	ASSLLGESPSLPSPP HHHHCCCCCCCCCCC	20.28	28285833
280	Phosphorylation	GESPSLPSPPNRSSS CCCCCCCCCCCCCCC	59.28	29899451
367	Phosphorylation	KEVVRTDSLKGRRGR EEEEECCCCCCCCCC	31.22	29176673
615	Phosphorylation	EDLVPPPSVIDKLFL HHCCCCCHHHHHHHH	37.16	28418008

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
377	S	Phosphorylation	Kinase	RSK-SUBFAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NR4A3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NR4A3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RORB_MOUSE	Rorb	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.