dbPTM

TBX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TBX1_MOUSE
UniProt AC	P70323
Protein Name	T-box transcription factor TBX1
Gene Name	Tbx1
Organism	Mus musculus (Mouse).
Sequence Length	479
Subcellular Localization	Nucleus .
Protein Description	Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries..
Protein Sequence	MHFSTVTRDMEAFAASSLSGLGSPSPGADPFGPREPPPPRYDPCAAVPGAPGPPPPRAYPFAPAPGAAGSSAAESEGPGASRAAAVKAPVKKNPKVASVSVQLEMKALWDEFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSWLVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGQIILNSMHRYQPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGFRDCDPEDWPRNHRPGALPLVSAFARSRNPVASPTQPNGSDKDAAEARREFDRDSGPAALGDATHPPQLLARVLSPALPGPGGLVPLPGGSGGRHSPPHADLRLEAPGASEPLHHHPYKYPAAAYDHYLGAKSRPAPYPLPGLRGHGYHPHAHPHAHPHHHHHPAVNPAAAAAAAAAANVYSSAAAPPGAYDYCPR

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
310	Phosphorylation	LVSAFARSRNPVASP HHHHHHHCCCCCCCC	32.74	29899451
316	Phosphorylation	RSRNPVASPTQPNGS HCCCCCCCCCCCCCC	28.81	29899451
318	Phosphorylation	RNPVASPTQPNGSDK CCCCCCCCCCCCCCH	54.91	28609623
323	Phosphorylation	SPTQPNGSDKDAAEA CCCCCCCCCHHHHHH	48.40	28609623
374	Phosphorylation	LVPLPGGSGGRHSPP EECCCCCCCCCCCCC	43.95	26643407
379	Phosphorylation	GGSGGRHSPPHADLR CCCCCCCCCCCCCEE	38.47	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of TBX1_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TBX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TBX1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WNT5A_MOUSE	Wnt5a	genetic	22438823
SMRD1_MOUSE	Smarcd1	physical	22438823
SETD7_MOUSE	Setd7	physical	22438823

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TBX1_MOUSE

Related Literatures of Post-Translational Modification