WNT5A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: WNT5A_MOUSE
• UniProt AC: P22725
• Protein Name: Protein Wnt-5a
• Gene Name: Wnt5a
• Organism: Mus musculus (Mouse).
• Sequence Length: 380
• Subcellular Localization: Secreted, extracellular space, extracellular matrix . Secreted .
• Protein Description: Ligand for members of the frizzled family of seven transmembrane receptors. [PubMed: 17117926 Can activate or inhibit canonical Wnt signaling, depending on receptor context]
• Protein Sequence: MKKPIGILSPGVALGTAGGAMSSKFFLMALATFFSFAQVVIEANSWWSLGMNNPVQMSEVYIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWGGCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLVYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
104	S-palmitoylation	AKTGIKECQYQFRHR HHHCHHHHHHHHHCC	3.76	17117926
114	N-linked_Glycosylation	QFRHRRWNCSTVDNT HHHCCCCCCCCCCCC	14.19	17117926
120	N-linked_Glycosylation	WNCSTVDNTSVFGRV CCCCCCCCCCHHCEE	29.89	17117926
244	O-palmitoleoylation	ACKCHGVSGSCSLKT HHHCCCCCCCCCCCC	29.58	-
312	N-linked_Glycosylation	SPDYCVRNESTGSLG CCCCEEECCCCCCCC	27.46	17117926
326	N-linked_Glycosylation	GTQGRLCNKTSEGMD CCCCCCCCCCCCCCC	56.05	17117926

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of WNT5A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of WNT5A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of WNT5A_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRP6_MOUSE	Lrp6	physical	19056682
RYK_MOUSE	Ryk	physical	16723543

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Post-translational palmitoylation and glycosylation of Wnt-5a arenecessary for its signalling.";
Kurayoshi M., Yamamoto H., Izumi S., Kikuchi A.;
Biochem. J. 402:515-523(2007).
Cited for: FUNCTION, PALMITOYLATION AT CYS-104, GLYCOSYLATION AT ASN-114;ASN-120; ASN-312 AND ASN-326, AND MUTAGENESIS OF CYS-104; ASN-114;ASN-120; ASN-312 AND ASN-326.
PubMed: 17117926

Palmitoylation

"Post-translational palmitoylation and glycosylation of Wnt-5a arenecessary for its signalling.";
Kurayoshi M., Yamamoto H., Izumi S., Kikuchi A.;
Biochem. J. 402:515-523(2007).
Cited for: FUNCTION, PALMITOYLATION AT CYS-104, GLYCOSYLATION AT ASN-114;ASN-120; ASN-312 AND ASN-326, AND MUTAGENESIS OF CYS-104; ASN-114;ASN-120; ASN-312 AND ASN-326.
PubMed: 17117926