dbPTM

LRP6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	LRP6_MOUSE
UniProt AC	O88572
Protein Name	Low-density lipoprotein receptor-related protein 6
Gene Name	Lrp6
Organism	Mus musculus (Mouse).
Sequence Length	1613
Subcellular Localization	Cell membrane Single-pass type I membrane protein. Endoplasmic reticulum. Membrane raft . On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palm
Protein Description	Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity)..
Protein Sequence	MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFGHGLIYWSDVSEEAIKRTEFNKSESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFVIINTEIYWPNGLTLDYQERKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWTDWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLMENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGTIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQLPDLMGLKATSVHRVIGSNPCAEDNGGCSHLCLYRPQGLRCACPIGFELIGDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSDMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPSTFLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNSIRKAHEDGGQGFNVVANSVANQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGRSVGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSKLGKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVLCLIDQFRCANGQCVGKHKKCDHSVDCSDRSDELDCYPTEEPAPQATNTVGSVIGVIVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHSPASVPLGYVPHPSSLSGSLPGMSRGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDVNYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	N-linked_Glycosylation	DATNGKENATIVVGG ECCCCCCCEEEEECC	45.96	-
81	N-linked_Glycosylation	AIKRTEFNKSESVQN HHHHCCCCCCHHCCE	40.48	-
281	N-linked_Glycosylation	FSQQRQPNATNPCGI HCCCCCCCCCCCCCC	51.57	-
433	N-linked_Glycosylation	RIEVTRLNGTMRKIL EEEEEEECCCEEEEE	40.37	-
486	N-linked_Glycosylation	SDRVVLVNTSLGWPN CCEEEEEECCCCCCC	21.57	-
539	Phosphorylation	IPHIFGFTLLGDYVY CCEEEEEEEECCEEE	22.81	25777480
544	Phosphorylation	GFTLLGDYVYWTDWQ EEEEECCEEEECHHH	8.14	25777480
546	Phosphorylation	TLLGDYVYWTDWQRR EEECCEEEECHHHHH	9.07	25777480
548	Phosphorylation	LGDYVYWTDWQRRSI ECCEEEECHHHHHHH	15.07	25777480
679	Phosphorylation	TDNRIYWTDISLKTI CCCEEEEEECCHHHH	13.39	-
692	N-linked_Glycosylation	TISRAFMNGSALEHV HHHHHHHCCHHHHHH	34.51	-
859	N-linked_Glycosylation	RRSIERANKTSGQNR HHHHHHHHCCCCCCC	55.12	-
865	N-linked_Glycosylation	ANKTSGQNRTIIQGH HHCCCCCCCEEEEHH	46.73	-
926	N-linked_Glycosylation	HYSLNADNRTCSAPS CEECCCCCCEECCCC	38.46	-
1189	Phosphorylation	QARIAQLSDIHAVKE HHHHHHHHHHHHHHC	23.57	26026062
1394	S-palmitoylation	SGTIYFICQRMLCPR CCHHHHHHHHHCCCC	1.18	-
1399	S-palmitoylation	FICQRMLCPRMKGDG HHHHHHCCCCCCCCC	1.15	-
1420	Phosphorylation	YVVHSPASVPLGYVP EEEECCCCCCCCCCC	27.87	-
1430	Phosphorylation	LGYVPHPSSLSGSLP CCCCCCHHHCCCCCC	40.66	-
1444	Phosphorylation	PGMSRGKSMISSLSI CCCCCCHHHHHHCEE	24.95	-
1469	Phosphorylation	RAHVTGASSSSSSST CCCCCCCCCCCCCCC	31.90	23684622
1470	Phosphorylation	AHVTGASSSSSSSTK CCCCCCCCCCCCCCC	33.43	23684622
1471	Phosphorylation	HVTGASSSSSSSTKG CCCCCCCCCCCCCCC	31.57	23684622
1475	Phosphorylation	ASSSSSSSTKGTYFP CCCCCCCCCCCCCCC	35.77	23684622
1479	Phosphorylation	SSSSTKGTYFPAILN CCCCCCCCCCCEEEC	24.44	-
1490	Phosphorylation	AILNPPPSPATERSH EEECCCCCCCCCCCE	32.70	26824392
1493	Phosphorylation	NPPPSPATERSHYTM CCCCCCCCCCCEEEE	35.00	26745281
1504	Phosphorylation	HYTMEFGYSSNSPST EEEEEECCCCCCCCC	17.78	29514104
1505	Phosphorylation	YTMEFGYSSNSPSTH EEEEECCCCCCCCCC	24.35	29550500
1506	Phosphorylation	TMEFGYSSNSPSTHR EEEECCCCCCCCCCC	32.61	23984901
1508	Phosphorylation	EFGYSSNSPSTHRSY EECCCCCCCCCCCCC	23.36	26643407
1510	Phosphorylation	GYSSNSPSTHRSYSY CCCCCCCCCCCCCCC	36.34	23984901
1511	Phosphorylation	YSSNSPSTHRSYSYR CCCCCCCCCCCCCCC	25.37	23984901
1515	Phosphorylation	SPSTHRSYSYRPYSY CCCCCCCCCCCCCEE	15.07	29514104
1517	Phosphorylation	STHRSYSYRPYSYRH CCCCCCCCCCCEECC	13.84	29514104
1520	Phosphorylation	RSYSYRPYSYRHFAP CCCCCCCCEECCCCC	14.88	29514104
1539	Phosphorylation	CSTDVCDSDYAPSRR CCCCCCCCCCCCCCC	27.65	29514104
1541	Phosphorylation	TDVCDSDYAPSRRMT CCCCCCCCCCCCCCC	25.10	29514104
1562	Phosphorylation	GYTSDVNYDSEPVPP CCCCCCCCCCCCCCC	22.24	26032504
1564	Phosphorylation	TSDVNYDSEPVPPPP CCCCCCCCCCCCCCC	33.18	29514104
1572	Phosphorylation	EPVPPPPTPRSQYLS CCCCCCCCCHHHCCC	36.79	29514104
1579	Phosphorylation	TPRSQYLSAEENYES CCHHHCCCHHHCCCC	28.80	-
1590	Phosphorylation	NYESCPPSPYTERSY CCCCCCCCCCCCCCC	18.71	26745281
1593	Phosphorylation	SCPPSPYTERSYSHH CCCCCCCCCCCCCCC	28.45	26745281
1607	Phosphorylation	HLYPPPPSPCTDSS- CCCCCCCCCCCCCC-	38.08	26643407
1610	Phosphorylation	PPPPSPCTDSS---- CCCCCCCCCCC----	42.15	26643407
1612	Phosphorylation	PPSPCTDSS------ CCCCCCCCC------	21.57	26643407
1613	Phosphorylation	PSPCTDSS------- CCCCCCCC-------	47.23	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1420	S	Phosphorylation	Kinase	CK1	-	Uniprot
1430	S	Phosphorylation	Kinase	CK1	-	Uniprot
1490	S	Phosphorylation	Kinase	CDK14	O35495	Uniprot
1490	S	Phosphorylation	Kinase	GRK5	Q8VEB1	Uniprot
1490	S	Phosphorylation	Kinase	GRK6	O70293	Uniprot
1493	T	Phosphorylation	Kinase	CK1	-	Uniprot
1579	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
1579	S	Phosphorylation	Kinase	CK2A1	Q60737	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1479	T	Phosphorylation	-
Phosphorylated, in vitro, by casein kinase I on Thr-1479 (By similarity).
1490	S	Phosphorylation	-
Phosphorylation at Ser-1490 by CDK14 during G2/M phase leads to regulation of the Wnt signaling pathway during the cell cycle.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of LRP6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
WNT1_MOUSE	Wnt1	physical	16126904
DKK1_MOUSE	Dkk1	physical	16126904
KREM2_MOUSE	Kremen2	physical	16126904
WNT5A_MOUSE	Wnt5a	physical	19056682
WNT5A_MOUSE	Wnt5a	genetic	19056682
MESD_MOUSE	Mesdc2	physical	16126904
MESD_MOUSE	Mesdc2	physical	12581525

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of LRP6_MOUSE

Related Literatures of Post-Translational Modification

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