| UniProt ID | SETD7_MOUSE | |
|---|---|---|
| UniProt AC | Q8VHL1 | |
| Protein Name | Histone-lysine N-methyltransferase SETD7 | |
| Gene Name | Setd7 | |
| Organism | Mus musculus (Mouse). | |
| Sequence Length | 366 | |
| Subcellular Localization | Nucleus. Chromosome. | |
| Protein Description | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.. | |
| Protein Sequence | MDSDDEVVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGEKNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDSDGRLIFKGQYKDNNRHGVCWIHYPDGGSLVGEVNEDGEMTGEKIAYVYPDQRTALYGKFIDGEMLEGKLATLMATEEGRPHFEVTSGSSVYHFDKSTSSCISSDALLPDPYESERVYVADSLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCVYDLFVHPRFGPIKCIRTLRAVEAEEELTVAYGYDHSPPGKSGPEAPEWYQVELKAFQATQQK | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 | Phosphorylation | -----MDSDDEVVEE -----CCCHHHHHHH | 45.74 | 25619855 | |
| 45 | Acetylation | GNFVHGEKNGRGKFF CCEECCEECCCEEEE | 70.10 | 15608243 | |
| 45 | Ubiquitination | GNFVHGEKNGRGKFF CCEECCEECCCEEEE | 70.10 | 27667366 | |
| 107 | Ubiquitination | SDGRLIFKGQYKDNN CCCCEEEEEEECCCC | 37.80 | 27667366 | |
| 225 | Phosphorylation | VADSLISSAGEGLFS EEHHHHHCCCCCCCC | 33.04 | 29899451 | |
| 317 | Ubiquitination | HPRFGPIKCIRTLRA CCCCCCCEEEEEEEE | 27.09 | 22790023 | |
| 317 | Acetylation | HPRFGPIKCIRTLRA CCCCCCCEEEEEEEE | 27.09 | 22826441 | |
| 335 | Phosphorylation | EEELTVAYGYDHSPP CEEEEEEECCCCCCC | 16.33 | 21082442 | |
| 337 | Phosphorylation | ELTVAYGYDHSPPGK EEEEEECCCCCCCCC | 9.60 | 19060867 | |
| 340 | Phosphorylation | VAYGYDHSPPGKSGP EEECCCCCCCCCCCC | 29.86 | 22817900 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SETD7_MOUSE !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SETD7_MOUSE !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SETD7_MOUSE !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| RN111_MOUSE | Rnf111 | physical | 27292644 | |
| SMUF1_MOUSE | Smurf1 | physical | 27292644 | |
| SMUF2_MOUSE | Smurf2 | physical | 27292644 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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