RN111_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN111_MOUSE
• UniProt AC: Q99ML9
• Protein Name: E3 ubiquitin-protein ligase Arkadia {ECO:0000305|PubMed:11298452}
• Gene Name: Rnf111 {ECO:0000312|MGI:MGI:1934919}
• Organism: Mus musculus (Mouse).
• Sequence Length: 989
• Subcellular Localization: Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol.
• Protein Description: E3 ubiquitin-protein ligase required for mesoderm patterning during embryonic development. [PubMed: 11298452 Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP]
• Protein Sequence: MSQWTPEFNELYTLKVAMKSGTPDAPTTQESLKAVLLHPQPLGATKSFPAEVEMINSKVGNEFSHLCDDSQKQEKDMTGNQQEQEKSGVVRKKRKSQQAGPSYVQNCVKENQEILGRRQQLETPSDEDNDSSLSECLSSPSSSLHFGGSDTVTSDEDKEVSVRHTQPVLSAKSRSHSARSHKWPRTEADPVPSLLMKRPCFHGSALRRVTCRKRLVKSSSSQRTQKQKERMLVQRKKREALAQRKYALLSSSSSSSENDLSSDSSSSSSTDGEEDLCASASENPSNPAAPSGSIDEDVVVIEASFTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHTGRPQESRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTIVPTTSARMDSQTTSASINNSNPSTSEQASDTTSTVASSQPSTVSETEATLTSNSATGSSVGDDVRRTASSAVPESGPPAMPRLPSCCPQHSPCGGTSQSHHALAHPHSSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVERPQVQAPCGANSSSGSSYHDQQALPVDLSNSALRTHGSGGFHGASAFDPCCPVTSSRAAVFGHQAAAAPTQPLSIDGYGSSMVAQPQPQPPPQPSLSSCRHYMPPPYASLTRPLHHQASACHHSHGNAPPQTQPPPQVDYVIPHPVHAFHSQISSHAASHPVAPPPPTHLGSTAAPIPQHLPPAHQPISHHIPAPAPSAQRLHPHEVMQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAPERTAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYISSGLDGASFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVTTDWFSQRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
20	Phosphorylation	TLKVAMKSGTPDAPT HHHHHHHCCCCCCCC	34.51	26643407
22	Phosphorylation	KVAMKSGTPDAPTTQ HHHHHCCCCCCCCCH	25.70	26643407
161	Phosphorylation	SDEDKEVSVRHTQPV CCCCCCEEEEECCCE	17.96	30635358
165	Phosphorylation	KEVSVRHTQPVLSAK CCEEEEECCCEEEEC	24.81	30635358
170	Phosphorylation	RHTQPVLSAKSRSHS EECCCEEEECCCCCC	33.61	30635358
173	Phosphorylation	QPVLSAKSRSHSARS CCEEEECCCCCCCCC	38.44	30635358
338	Phosphorylation	ESYRSRSTLGHSRSH CCCCCCCCCCCCCCC	35.33	30165576
342	Phosphorylation	SRSTLGHSRSHWSQG CCCCCCCCCCCCCCC	33.41	30165576
344	Phosphorylation	STLGHSRSHWSQGSS CCCCCCCCCCCCCCC	32.11	30165576
347	Phosphorylation	GHSRSHWSQGSSSHT CCCCCCCCCCCCCCC	21.17	30165576
350	Phosphorylation	RSHWSQGSSSHTGRP CCCCCCCCCCCCCCC	22.49	30165576
351	Phosphorylation	SHWSQGSSSHTGRPQ CCCCCCCCCCCCCCH	32.72	30165576
352	Phosphorylation	HWSQGSSSHTGRPQE CCCCCCCCCCCCCHH	27.11	30165576
354	Phosphorylation	SQGSSSHTGRPQESR CCCCCCCCCCCHHHH	36.51	30165576
360	Phosphorylation	HTGRPQESRNRSRIS CCCCCHHHHCHHHHH	29.61	30165576

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN111_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN111_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN111_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AXIN1_MOUSE	Axin1	physical	16601693
SMAD7_MOUSE	Smad7	physical	16601693
SMAD2_HUMAN	SMAD2	physical	17341133
SMAD3_HUMAN	SMAD3	physical	17341133
AP2M1_HUMAN	AP2M1	physical	20965945
AP2B1_HUMAN	AP2B1	physical	20965945
AP2A2_HUMAN	AP2A2	physical	20965945
SUMO2_HUMAN	SUMO2	physical	24912682
CBX4_HUMAN	CBX4	physical	24912682

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.