SMRD1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMRD1_MOUSE
• UniProt AC: Q61466
• Protein Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1
• Gene Name: Smarcd1
• Organism: Mus musculus (Mouse).
• Sequence Length: 515
• Subcellular Localization: Nucleus .
• Protein Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [PubMed: 17640523 Has a strong influence on vitamin D-mediated transcriptional activity from an enhancer vitamin D receptor element (VDRE May be a link between mammalian SWI-SNF-like chromatin remodeling complexes and the vitamin D receptor (VDR) heterodimer. Mediates critical interactions between nuclear receptors and the BRG1/SMARCA4 chromatin-remodeling complex for transactivation (By similarity]
• Protein Sequence: MAARAGFQSVAPSGGAGASGGAGVAAALGPGGTPGPPVRMGPAPGQGLYRSPMPGAAYPRPGMLPGSRMTPQGPSMGPPGYGGNPSVRPGLAQSGMDQSRKRPAPQQIQQVQQQAVQNRNHNAKKKKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRLDIQEALKRPIKQKRKLRIFISNTFNPAKSDAEDGEGTVASWELRVEGRLLEDAALSKYDATKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTATTQETDGFQVKRPGDVNVRCTVLLMLDYQPPQFKLDPRLARLLGIHTQTRPVIIQALWQYIKTHKLQDPHEREFVLCDKYLQQIFESQRMKFSEIPQRLHALLMPPEPIIINHVISVDPNDQKKTACYDIDVEVDDTLKTQMNSFLLSTASQQEIATLDNKIHETIETINQLKTQREFMLSFARDPQGFINDWLQSQCRDLKTMTDVVGNPEEERRAEFYFQPWAQEAVCRYFYSKVQQRRQELEQALGIRNT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	AALGPGGTPGPPVRM HHCCCCCCCCCCCCC	30.87	26643407
68	Methylation	PGMLPGSRMTPQGPS CCCCCCCCCCCCCCC	38.62	-
70	Phosphorylation	MLPGSRMTPQGPSMG CCCCCCCCCCCCCCC	16.02	26643407
88	Asymmetric dimethylarginine	YGGNPSVRPGLAQSG CCCCCCCCCCCHHCC	24.73	-
88	Methylation	YGGNPSVRPGLAQSG CCCCCCCCCCCHHCC	24.73	24129315
100	Dimethylation	QSGMDQSRKRPAPQQ HCCCCCCCCCCCHHH	33.11	-
100	Methylation	QSGMDQSRKRPAPQQ HCCCCCCCCCCCHHH	33.11	54541477
187	Phosphorylation	RKLRIFISNTFNPAK CCCEEEEECCCCCCC	21.04	26643407
189	Phosphorylation	LRIFISNTFNPAKSD CEEEEECCCCCCCCC	20.28	26643407
195	Phosphorylation	NTFNPAKSDAEDGEG CCCCCCCCCCCCCCC	44.13	26643407
203	Phosphorylation	DAEDGEGTVASWELR CCCCCCCCEEEEEEE	14.48	-
223	Acetylation	LEDAALSKYDATKQK ECHHHHHCCCCHHHH	48.26	23806337
464	Ubiquitination	QSQCRDLKTMTDVVG HHHHCCCCHHHHCCC	40.31	22790023
515	Phosphorylation	QALGIRNT------- HHHCCCCC-------	30.09	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMRD1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMRD1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMRD1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
JUN_RAT	Jun	physical	11053448
FOS_RAT	Fos	physical	11053448
JUNB_HUMAN	JUNB	physical	11053448
SMCA2_MOUSE	Smarca2	physical	11053448
TBX1_MOUSE	Tbx1	physical	22438823
P53_MOUSE	Trp53	physical	18303029

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.