SMCA2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMCA2_MOUSE
• UniProt AC: Q6DIC0
• Protein Name: Probable global transcription activator SNF2L2
• Gene Name: Smarca2 {ECO:0000312|MGI:MGI:99603}
• Organism: Mus musculus (Mouse).
• Sequence Length: 1577
• Subcellular Localization: Nucleus .
• Protein Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. [PubMed: 22952240]
• Protein Sequence: MSTPTDPAAMPHPGPSPGPGPSPGPILGPSPGPGPSPGSVHSMMGPSPGPPSVSHPLSTMGSADFPQEGMHQLHKPMDGIHDKGIVEDVHCGSMKGTSMRPPHPGMGPPQSPMDQHSQGYMSPHPSPLGAPEHVSSPTPPQMPPSQPGALIPGDPQAMNQPNRGPSPFSPVQLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTLPGMQQQQQQQQQQQQQQQQQQQQQQQQQQPQQPQQQAQAQPQQQQQQQQQPALVSYNRPSGPGQELLLSGQSAPQKLSAPAPSGRPSPAPQAAVQPTATAVPGPSVQQPAPGQPSPVLQLQQKQSRISPIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGEPALGPDGEPIDESSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYEVAPRSDSEESESDYEEEDEEEESSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEEDEVPDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKEDVEKAKKRRGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDSSGRQLSEVFIQLPSRKDLPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFKSARQKIAKEEESEEESNEEEEEDDEEESESEAKSVKVKIKLNKKEEKGRDTGKGKKRPNRGKAKPVVSDFDSDEEQEENEQSEASGTDNE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	VEDVHCGSMKGTSMR EEECCCCCCCCCCCC	23.79	29176673
166	Phosphorylation	NQPNRGPSPFSPVQL CCCCCCCCCCCHHHH	41.21	28833060
169	Phosphorylation	NRGPSPFSPVQLHQL CCCCCCCCHHHHHHH	27.78	-
184	Acetylation	RAQILAYKMLARGQP HHHHHHHHHHHCCCC	23.10	-
284	Phosphorylation	QSAPQKLSAPAPSGR CCCCCCCCCCCCCCC	38.96	19060867
289	Phosphorylation	KLSAPAPSGRPSPAP CCCCCCCCCCCCCCC	49.92	19060867
293	Phosphorylation	PAPSGRPSPAPQAAV CCCCCCCCCCCCCCC	32.12	21183079
303	Phosphorylation	PQAAVQPTATAVPGP CCCCCCCCCCCCCCC	21.39	23984901
305	Phosphorylation	AAVQPTATAVPGPSV CCCCCCCCCCCCCCC	30.57	23984901
311	Phosphorylation	ATAVPGPSVQQPAPG CCCCCCCCCCCCCCC	38.17	23984901
321	Phosphorylation	QPAPGQPSPVLQLQQ CCCCCCCCCCHHHCH	21.54	22817900
334	Phosphorylation	QQKQSRISPIQKPQG CHHHHCCCCCCCCCC	18.16	25521595
338	Ubiquitination	SRISPIQKPQGLDPV HCCCCCCCCCCCCHH	39.77	-
409	Phosphorylation	VACMRRDTTLETALN HHHHHCCCHHHHHHC	31.31	30352176
410	Phosphorylation	ACMRRDTTLETALNS HHHHCCCHHHHHHCC	27.21	30352176
413	Phosphorylation	RRDTTLETALNSKAY HCCCHHHHHHCCHHH	39.29	30352176
418	Ubiquitination	LETALNSKAYKRSKR HHHHHCCHHHHHHHH	55.45	-
470	Phosphorylation	HAKDFKEYHRSVAGK HHHHHHHHHHHHHHH	11.79	28285833
473	Phosphorylation	DFKEYHRSVAGKIQK HHHHHHHHHHHHHHH	11.73	28285833
482	Phosphorylation	AGKIQKLSKAVATWH HHHHHHHHHHHHHHH	26.13	-
568	Acetylation	KKKRRRRKKKAEENA HHHHHHHHHHHHHHC	57.73	7619081
570	Acetylation	KRRRRKKKAEENAEG HHHHHHHHHHHHCCC	65.15	7619091
592	Phosphorylation	DGEPIDESSQMSDLP CCCCCCCCCCCCCCC	23.32	21082442
593	Phosphorylation	GEPIDESSQMSDLPV CCCCCCCCCCCCCCC	28.05	21082442
596	Phosphorylation	IDESSQMSDLPVKVT CCCCCCCCCCCCEEE	28.49	25521595
601	Acetylation	QMSDLPVKVTHTETG CCCCCCCEEEECCCC	39.20	7619101
609	Acetylation	VTHTETGKVLFGPEA EEECCCCCEEECCCC	43.09	23806337
671	Phosphorylation	KILLDPNSEEVSEKD HHHCCCCCHHCCHHH	40.29	27841257
675	Phosphorylation	DPNSEEVSEKDAKQI CCCCHHCCHHHHHHH	42.06	30635358
703	Phosphorylation	MQYSARGSQSYYTVA HCHHCCCCCHHHHHH	15.48	28833060
825	Phosphorylation	SLVPQLRSGKFNVLL HHHHHHHCCCCCEEE	55.73	-
1002	Acetylation	DGSEKDKKGKGGAKT CCCCCCCCCCCHHHH	75.81	68851
1004	Acetylation	SEKDKKGKGGAKTLM CCCCCCCCCHHHHHH	64.15	68855
1008	Acetylation	KKGKGGAKTLMNTIM CCCCCHHHHHHHHHH	45.53	68859
1300	Phosphorylation	DAEVERLTCEEEEEK HHHHEEECCHHHHHH	24.88	29550500
1313	Phosphorylation	EKIFGRGSRQRRDVD HHHCCCCCCCCCCCC	24.71	29176673
1382	Phosphorylation	RPPAEKLSPNPPKLT CCCHHHCCCCCCHHH	33.43	27087446
1398	Phosphorylation	QMNAIIDTVINYKDS HHHHHHHHHHHCCCC	16.93	21189417
1402	Phosphorylation	IIDTVINYKDSSGRQ HHHHHHHCCCCCCCC	12.68	21189417
1499	Phosphorylation	KIAKEEESEEESNEE HHHHHHHCHHHCCCC	54.29	27087446
1503	Phosphorylation	EEESEEESNEEEEED HHHCHHHCCCCCCCC	53.47	27087446
1515	Phosphorylation	EEDDEEESESEAKSV CCCCHHHCHHHHHHH	50.10	27087446
1517	Phosphorylation	DDEEESESEAKSVKV CCHHHCHHHHHHHEE	52.73	23737553
1540	Acetylation	EKGRDTGKGKKRPNR HCCCCCCCCCCCCCC	70.43	66197
1542	Acetylation	GRDTGKGKKRPNRGK CCCCCCCCCCCCCCC	49.44	66205
1549	Acetylation	KKRPNRGKAKPVVSD CCCCCCCCCCCCCCC	50.42	66207
1551	Acetylation	RPNRGKAKPVVSDFD CCCCCCCCCCCCCCC	41.66	66209
1555	Phosphorylation	GKAKPVVSDFDSDEE CCCCCCCCCCCCHHH	32.56	23375375
1559	Phosphorylation	PVVSDFDSDEEQEEN CCCCCCCCHHHHHHH	47.09	23684622
1569	Phosphorylation	EQEENEQSEASGTDN HHHHHHHHHHCCCCC	29.02	23684622
1572	Phosphorylation	ENEQSEASGTDNE-- HHHHHHHCCCCCC--	37.87	23684622
1574	Phosphorylation	EQSEASGTDNE---- HHHHHCCCCCC----	32.91	23684622

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SMCA2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMCA2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMCA2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NR0B2_MOUSE	Nr0b2	physical	19805516
CREST_MOUSE	Ss18l1	physical	19279220
SFPQ_MOUSE	Sfpq	physical	19279220
NONO_MOUSE	Nono	physical	19279220
MBB1A_MOUSE	Mybbp1a	physical	19279220
SRRM2_MOUSE	Srrm2	physical	19279220
BRD9_MOUSE	Brd9	physical	19279220
BRD7_MOUSE	Brd7	physical	19279220
BCL7A_MOUSE	Bcl7a	physical	19279220
ACTG_MOUSE	Actg1	physical	19279220
ACL6A_MOUSE	Actl6a	physical	19279220
SNF5_MOUSE	Smarcb1	physical	19279220
SMCE1_MOUSE	Smarce1	physical	19279220
SMRD3_MOUSE	Smarcd3	physical	19279220
SMRD1_MOUSE	Smarcd1	physical	19279220
SMRC1_MOUSE	Smarcc1	physical	19279220
SMRC2_MOUSE	Smarcc2	physical	19279220

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.