BRD9_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRD9_MOUSE
• UniProt AC: Q3UQU0
• Protein Name: Bromodomain-containing protein 9
• Gene Name: Brd9
• Organism: Mus musculus (Mouse).
• Sequence Length: 596
• Protein Description: Plays a role in chromatin remodeling and regulation of transcription. Acts as a chromatin reader that recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated..
• Protein Sequence: MGKKHKKHKAEWRSSYEDYTDTPLEKPLKLVLKVGGSEVTELSGSGHDSSYYDDRSDHERERHREKKKKKKKKSEKEKHLDEEERRKRKEEKKRKREKEHCDSEGEADAFDPGKKVEVEPPPDRPVRACRTQPAENESTPIQRLLEHFLRQLQRKDPHGFFAFPVTDAIAPGYSMIIKHPMDFGTMKDKIVANEYKSVTEFKADFKLMCDNAMTYNRPDTVYYKLAKKILHAGFKMMSKAALLGSEDPAAEEPVPEVVPVQVETTKKSKKPSREVISCMFEPEGNACSLTDSTAEEHVLALVEHAADEARDRINRFLPGGKMGYLKKLGDGSLLYSVVNAPEPDADEEETHPVDLSSLSSKLLPGFTTLGFKDERRNKVTFLSSASTALSMQNNSVFGDLKSDEMELLYSAYGDETGVQCALSLQEFVKDAGSYSKKMVDDLLDQITGGDHSRMIFQLKQRRSIPMRPADEMKVGDPLGESGGPVLDFMSMKQYPDVSLDVSMLSSLGKVKKELDHEDSHLNLDETARLLQDLHEAQAERGGSRPSSNLSSLSTASEREHPPPGSPSRLSVGEQPDVAHDPYEFLQSPEPAAPAKN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	KHKAEWRSSYEDYTD HCCCHHHHCCCCCCC	38.04	25338131
15	Phosphorylation	HKAEWRSSYEDYTDT CCCHHHHCCCCCCCC	24.78	24704852
37	Phosphorylation	LVLKVGGSEVTELSG EEEEECCCEEEECCC	23.98	25777480
40	Phosphorylation	KVGGSEVTELSGSGH EECCCEEEECCCCCC	27.45	25777480
43	Phosphorylation	GSEVTELSGSGHDSS CCEEEECCCCCCCCC	25.36	25159016
45	Phosphorylation	EVTELSGSGHDSSYY EEEECCCCCCCCCCC	29.58	25159016
49	Phosphorylation	LSGSGHDSSYYDDRS CCCCCCCCCCCCCCC	17.99	25159016
50	Phosphorylation	SGSGHDSSYYDDRSD CCCCCCCCCCCCCCH	33.50	28066266
51	Phosphorylation	GSGHDSSYYDDRSDH CCCCCCCCCCCCCHH	18.18	25159016
52	Phosphorylation	SGHDSSYYDDRSDHE CCCCCCCCCCCCHHH	17.20	25777480
56	Phosphorylation	SSYYDDRSDHERERH CCCCCCCCHHHHHHH	50.76	21082442
103	Phosphorylation	REKEHCDSEGEADAF HHHHHCCCCCCCCCC	53.55	25521595
321	Acetylation	NRFLPGGKMGYLKKL HHHCCCCCCCCEEEC	34.76	19861903
326	Malonylation	GGKMGYLKKLGDGSL CCCCCCEEECCCCCE	37.15	26073543
372	Acetylation	GFTTLGFKDERRNKV CCCCCCCCCCCCCCE	57.81	-
395	Phosphorylation	ALSMQNNSVFGDLKS HHHHCCCCCCCCCCH	26.77	28576409
494	Phosphorylation	DFMSMKQYPDVSLDV CHHCCCCCCCCEEEH	8.90	-
502	Phosphorylation	PDVSLDVSMLSSLGK CCCEEEHHHHHHHHH	17.42	-
519	Phosphorylation	KELDHEDSHLNLDET HHCCCCCCCCCHHHH	27.21	25521595
551	Phosphorylation	RPSSNLSSLSTASER CCCCCHHHCCCCCCC	29.52	25195567
565	Phosphorylation	REHPPPGSPSRLSVG CCCCCCCCCCCCCCC	26.02	26824392
567	Phosphorylation	HPPPGSPSRLSVGEQ CCCCCCCCCCCCCCC	47.77	29899451
570	Phosphorylation	PGSPSRLSVGEQPDV CCCCCCCCCCCCCCC	27.28	25619855
582	Phosphorylation	PDVAHDPYEFLQSPE CCCCCCHHHHHHCCC	25.93	25619855
587	Phosphorylation	DPYEFLQSPEPAAPA CHHHHHHCCCCCCCC	33.12	27087446
588	Phosphorylation	PYEFLQSPEPAAPAK HHHHHHCCCCCCCCC	38.33	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRD9_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRD9_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRD9_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BRD9_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.