ACL6A_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ACL6A_MOUSE
• UniProt AC: Q9Z2N8
• Protein Name: Actin-like protein 6A
• Gene Name: Actl6a
• Organism: Mus musculus (Mouse).
• Sequence Length: 429
• Subcellular Localization: Nucleus .
• Protein Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. [PubMed: 17640523 Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity]
• Protein Sequence: MSGGVYGGDEVGALVFDIGSYTVRAGYAGEDCPKVDFPTAIGVVLERDDGSTMMEIDGDKGKQGGPTYYIDTNALRVPRENMEAISPLKNGMVEDWDSFQAILDHTYKMHVKSEASLHPVLMSEAPWNTRAKREKLTELMFEHYSIPAFFLCKTAVLTAFANGRSTGLILDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFITMQCRELFQEMNIELIPPYMIASKEAVREGSPANWKRKEKLPQVTRSWHNYMCNCVIQDFQASVLQVSDSTYDEQVAAQMPTVHYEFPNGYNCDFGAERLKIPEGLFDPSNVKGLSGNTMLGVSHVVTTSVGMCDIDIRPGLYGSVIVAGGNTLIQSFTDRLNRELSQKTPPSMRLKLIANNTTVERRFSSWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MSGGVYGGD ------CCCCCCCCC	44.23	-
6	Phosphorylation	--MSGGVYGGDEVGA --CCCCCCCCCCCCE	20.75	30387612
52	Phosphorylation	LERDDGSTMMEIDGD EECCCCCEEEEECCC	26.51	22871156
62	Ubiquitination	EIDGDKGKQGGPTYY EECCCCCCCCCCEEE	52.06	-
68	Phosphorylation	GKQGGPTYYIDTNAL CCCCCCEEEEECCCC	11.10	22871156
69	Phosphorylation	KQGGPTYYIDTNALR CCCCCEEEEECCCCC	8.52	22871156
86	Phosphorylation	RENMEAISPLKNGMV HHHHHHHCCCCCCCC	31.09	28066266
129	Phosphorylation	MSEAPWNTRAKREKL HCCCCCCHHHHHHHH	28.30	-
221	Phosphorylation	NIELIPPYMIASKEA CCHHCCCCCEECHHH	8.87	-
225	Phosphorylation	IPPYMIASKEAVREG CCCCCEECHHHHHCC	21.80	-
233	Phosphorylation	KEAVREGSPANWKRK HHHHHCCCCCCCCCH	18.98	26824392
242	Ubiquitination	ANWKRKEKLPQVTRS CCCCCHHHCCCCCHH	69.38	-
303	Ubiquitination	DFGAERLKIPEGLFD CCCCHHCCCCCCCCC	63.54	-
379	Acetylation	TPPSMRLKLIANNTT CCCHHHEEEHHCCCC	27.73	22826441
379	Malonylation	TPPSMRLKLIANNTT CCCHHHEEEHHCCCC	27.73	26320211
398	Phosphorylation	FSSWIGGSILASLGT HHHHHHHHHHHHHCH	14.82	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ACL6A_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ACL6A_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ACL6A_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ACL6A_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.