BRD7_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BRD7_MOUSE
• UniProt AC: O88665
• Protein Name: Bromodomain-containing protein 7
• Gene Name: Brd7
• Organism: Mus musculus (Mouse).
• Sequence Length: 651
• Subcellular Localization: Nucleus .
• Protein Description: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase (By similarity). Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR..
• Protein Sequence: MGKKHKKHKSDRHFYEEYVEKPLKLVLKVGGSEVTELSTGSSGHDSSLFEDRSDHDKHKDRKRKKRKKGEKQAPGEEKGRKRRRVKEDKKKRDRDRAENEVDRDLQCHVPIRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMSDLQKTRKQKERTDACQSGEDSGCWQREREDSGDAETQAFRSPAKDNKRKDKDVLEDKWRSSNSEREHEQIERVVQESGGKLTRRLANSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNRVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPNNFSISEFLATCQDYPYVMADSLLDVLTKGGHSRSLQDLDMSSPEDEGQTRALDTAKEAEITQIEPTGRLESSSQDRLTALQAVTTFGAPAEVFDSEEAEVFQRKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMYLAEQVTNNLKELTQQVTPGDVVSIHGVRKAMGISVPSPIVGNSFVDLTGECEEPKETSTAECGPDAS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	DRHFYEEYVEKPLKL CCCHHHHHHHCCEEE	11.28	25159016
32	Phosphorylation	LVLKVGGSEVTELST EEEEECCCEEEEECC	23.98	25293948
35	Phosphorylation	KVGGSEVTELSTGSS EECCCEEEEECCCCC	27.45	25293948
38	Phosphorylation	GSEVTELSTGSSGHD CCEEEEECCCCCCCC	25.21	19060867
39	Phosphorylation	SEVTELSTGSSGHDS CEEEEECCCCCCCCC	54.42	19060867
41	Phosphorylation	VTELSTGSSGHDSSL EEEECCCCCCCCCCC	32.98	21183079
42	Phosphorylation	TELSTGSSGHDSSLF EEECCCCCCCCCCCC	41.30	22817900
46	Phosphorylation	TGSSGHDSSLFEDRS CCCCCCCCCCCCCCC	24.22	25293948
47	Phosphorylation	GSSGHDSSLFEDRSD CCCCCCCCCCCCCCC	43.04	25293948
53	Phosphorylation	SSLFEDRSDHDKHKD CCCCCCCCCCCHHHH	52.17	25338131
197	Ubiquitination	YQSIEELKDNFKLMC CCCHHHHHHHHEEEE	54.64	22790023
265	Phosphorylation	ERTDACQSGEDSGCW HHCHHHHCCCCCCCC	43.99	26643407
279	Phosphorylation	WQREREDSGDAETQA CCCCCCCCCCHHHHH	33.54	25521595
284	Phosphorylation	EDSGDAETQAFRSPA CCCCCHHHHHHCCCC	27.24	25619855
289	Phosphorylation	AETQAFRSPAKDNKR HHHHHHCCCCCCCCC	23.82	26824392
311	Phosphorylation	DKWRSSNSEREHEQI HHHHCCCHHHHHHHH	39.72	27841257
328	Acetylation	VVQESGGKLTRRLAN HHHHHCCHHHHHHHH	50.65	23806337
380	Phosphorylation	MTTGRLQSGVNTLQG CCCCCCCCCCCCHHC	49.66	-
475	Phosphorylation	TKGGHSRSLQDLDMS HCCCCCCCHHHCCCC	33.14	25159016
482	Phosphorylation	SLQDLDMSSPEDEGQ CHHHCCCCCCCCHHH	42.27	21082442
483	Phosphorylation	LQDLDMSSPEDEGQT HHHCCCCCCCCHHHC	26.18	22942356
490	Phosphorylation	SPEDEGQTRALDTAK CCCCHHHCHHHHHHH	28.85	21743459
618	Phosphorylation	VRKAMGISVPSPIVG HHHHHCCCCCCCCCC	23.42	26643407
621	Phosphorylation	AMGISVPSPIVGNSF HHCCCCCCCCCCCCE	25.71	26643407
627	Phosphorylation	PSPIVGNSFVDLTGE CCCCCCCCEECCCCC	22.25	26643407

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BRD7_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BRD7_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BRD7_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of BRD7_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry.";
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.;
J. Proteome Res. 7:5314-5326(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, AND MASSSPECTROMETRY.
PubMed: 19367708