SMRD3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMRD3_MOUSE
• UniProt AC: Q6P9Z1
• Protein Name: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3
• Gene Name: Smarcd3
• Organism: Mus musculus (Mouse).
• Sequence Length: 483
• Subcellular Localization: Nucleus .
• Protein Description: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. [PubMed: 22952240]
• Protein Sequence: MAADEVAGGARKATKSKLFEFLVHGVRPGMPSGARMPHQGAPMGPPGSPYMGSPAVRPGLAPAGMEPARKRAAPPPGQSQAQGQGQPVPTAPARSRSAKRRKMADKILPQRIRELVPESQAYMDLLAFERKLDQTIMRKRVDIQEALKRPMKQKRKLRLYISNTFNPAKPDAEDSDGSIASWELRVEGKLLDDPSKQKRKFSSFFKSLVIELDKDLYGPDNHLVEWHRTPTTQETDGFQVKRPGDLSVRCTLLLMLDYQPPQFKLDPRLARLLGLHTQSRSAIVQALWQYVKTNRLQDSHDKEYINGDKYFQQIFDCPRLKFSEIPQRLTALLLPPDPIVINHVISVDPSDQKKTACYDIDVEVEEPLKGQMSSFLLSTANQQEISALDSKIHETIESINQLKIQRDFMLSFSRDPKGYVQDLLRSQSRDLKVMTDVAGNPEEERRAEFYHQPWSQEAVSRYFYCKIQQRRQELEQSLVVRNT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAADEVAGG ------CCHHHHCCC	24.50	-
175	Phosphorylation	AKPDAEDSDGSIASW CCCCCCCCCCCEEEE	35.06	21659605
178	Phosphorylation	DAEDSDGSIASWELR CCCCCCCCEEEEEEE	21.70	21659605
196	Ubiquitination	KLLDDPSKQKRKFSS EECCCHHHHHHHHHH	66.29	-
229	Phosphorylation	HLVEWHRTPTTQETD CEEEEECCCCCCCCC	16.46	22068056
374	Phosphorylation	PLKGQMSSFLLSTAN CCCCCHHHHHHHHCC	17.99	28494245
378	Phosphorylation	QMSSFLLSTANQQEI CHHHHHHHHCCHHHH	27.85	28494245

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
229	T	Phosphorylation	Kinase	MAPK11	Q15759	GPS
229	T	Phosphorylation	Kinase	P38B	Q9WUI1	PSP
229	T	Phosphorylation	Kinase	MAPK14	Q16539	GPS
229	T	Phosphorylation	Kinase	P38A	P47811	PSP

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SMRD3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMRD3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of SMRD3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.